Podcasts by [Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)

[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)

This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 21: FDA and EPA Regulatory Issues from 2007-11-27T15:05:09

Outline:Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the r...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems from 2007-11-15T22:03:09

Outline:Overview What does cGMP mean? Why GMP? Controlling processes means more predictable outcomes… Enforcement What can be learned from the semi-conductor industry clean-room and manufacturing? ...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 18: Designing nanodelivery systems for in-vivo use from 2007-11-12T15:48:32

Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplici...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 17: Assessing nanotoxicity at the single cell level from 2007-11-06T21:05:46

Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challen...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 16: Assessing drug efficacy at the single cell level from 2007-11-02T13:55:21

Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 15: Nanodelivery of therapeutic genes&molecular biosensor feedback control systems from 2007-10-30T19:31:03

Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe thera...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems from 2007-10-29T19:02:12

Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metaboli...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 13: Assessing Zeta Potentials from 2007-10-29T18:10:38

Outline:Introduction – the importance of the zeta potentialNanoparticle-nanoparticle interactionsNanoparticle-cell interactionsPart of the initial nanomedical system-cell targeting processLow zeta ...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles from 2007-10-01T03:33:43

With Donald E. Bergstrom as guest lecturer.

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo from 2007-09-26T21:57:14

Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by con...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 10: Nanomaterials for core design from 2007-09-26T21:52:51

Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells from 2007-09-24T20:48:43

Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence a...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 7: Normal&facilitated cell entry mechanisms from 2007-09-16T01:46:31

Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cells...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 5: Cell Targeting from 2007-09-12T22:41:56

Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make th...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 4: Designing"Theragnostic"Systems from 2007-09-04T22:37:30

Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuti...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 3: Overview of Basic Nanomedical Systems Design from 2007-08-29T15:35:57

Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around theconsequences o...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 2: Basic Concepts of Nanomedical Systems from 2007-08-28T17:54:56

Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control syst...

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[Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
BME 695N Lecture 1: Need for New Perspectives on Medicine from 2007-08-03T10:12:55

Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseId...

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