Podcasts by [Audio] BME 695N: Engineering Nanomedical Systems (Fall 2007)
This course will cover the basic concepts of design of integrated nanomedical systems for diagnostics and therapeutics. Topics to be covered include: why nanomedical approaches are needed, cell targeting strategies, choice of core nanomaterials, technologies for testing composition and...
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BME 695N Lecture 19: In vivo model systems to study nanomedical approaches to cancer detection and intervention from 2007-11-27T15:07:58
With Deborah Knapp as guest lecturer.
ListenBME 695N Lecture 21: FDA and EPA Regulatory Issues from 2007-11-27T15:05:09
Outline:Introduction and overview How does the FDA think about nanomedical systems? The 2006 Nanotechnology Task Force Some details of the Nanotechnology Task Force Report General findings of the r...
ListenBME 695N Lecture 20: GMP and issues of quality control manufacture of nanodelivery systems from 2007-11-15T22:03:09
Outline:Overview What does cGMP mean? Why GMP? Controlling processes means more predictable outcomes… Enforcement What can be learned from the semi-conductor industry clean-room and manufacturing? ...
ListenBME 695N Lecture 18: Designing nanodelivery systems for in-vivo use from 2007-11-12T15:48:32
Outline:Overview – the in-vitro to ex-vivo to in-vivo paradigm In-vitro - importance of choosing suitable cell lines Ex-vivo – adding the complexity of in-vivo background while keeping the simplici...
ListenBME 695N Lecture 17: Assessing nanotoxicity at the single cell level from 2007-11-06T21:05:46
Outline:Outline – the need for single cell measures of nanotoxicity There is more than one way for a cell to die... Necrosis" vs. "Apoptosis" There are other forms of "toxicity" Some other challen...
ListenBME 695N Lecture 16: Assessing drug efficacy at the single cell level from 2007-11-02T13:55:21
Outline:Introduction and overviewNanomedical treatment at the single cell level requires evaluation at the single cell levelFor evaluation purposes, does structure reveal function?The difficulty of...
ListenBME 695N Lecture 15: Nanodelivery of therapeutic genes&molecular biosensor feedback control systems from 2007-10-30T19:31:03
Outline:Introduction and overviewSome of the advantages of therapeutic genesSome of the advantages of molecular biosensor feedback control systemsWhy a nanodelivery approach is appropriateThe thera...
ListenBME 695N Lecture 14: Challenges of proper drug dosing with nanodelivery systems from 2007-10-29T19:02:12
Outline:Overview of drug dosing problemProblems of scaling up doses from animal systemsBasing dosing on size, area, weight of recipientVast differences between adults in terms of genetics, metaboli...
ListenBME 695N Lecture 13: Assessing Zeta Potentials from 2007-10-29T18:10:38
Outline:Introduction – the importance of the zeta potentialNanoparticle-nanoparticle interactionsNanoparticle-cell interactionsPart of the initial nanomedical system-cell targeting processLow zeta ...
ListenBME 695N Lecture 12: Introduction to X-ray Photoelectron Spectroscopy and the Examples of Biologically-Relevant Applications from 2007-10-19T15:26:02
With Dmitry Zemlyanov as guest lecturer.
ListenBME 695N Lecture 11: Construction of biomolecule conjugated nanoparticles from 2007-10-01T03:33:43
With Donald E. Bergstrom as guest lecturer.
ListenBME 695N Lecture 9: Atomic Force Microscopy (AFM) for Nanomedical Systems (cells and nanoparticles) from 2007-10-01T02:59:29
What Helen McNally as guest lecturer.
ListenBME 695N Lecture 6: Rare-event targeting of cells in-vitro and in-vivo from 2007-09-26T21:57:14
Outline:Assessing nanomedical system (NMS) targeting at the single cell levelFluorescent labeling of NMSsFirst estimates of NMS binding by fluorescence microscopyInternal of external binding by con...
ListenBME 695N Lecture 10: Nanomaterials for core design from 2007-09-26T21:52:51
Outline:IntroductionCore building blocksFunctional coresFunctionalizing the core surfaceFerric oxide coresParamagnetic coresSuperparamagnetic coresFerric nanorodsAdvantages and disadvantagesC60 and...
ListenBME 695N Lecture 8: Technologies for measuring nanomedical systems on/within cells from 2007-09-24T20:48:43
Outline:Introduction to measuring technologies for nanomedical system interaction with cellsThe importance of quantitative or at least semi-quantitative single cell measurementsto detect presence a...
ListenBME 695N Lecture 7: Normal&facilitated cell entry mechanisms from 2007-09-16T01:46:31
Outline:IntroductionThe general problem of cell entryChoosing modes of cell entryHow does Nature do it? (biomimetics)Non-specific uptake mechanismsPinocytosis by all cellsPhagocytosis by some cells...
ListenBME 695N Lecture 5: Cell Targeting from 2007-09-12T22:41:56
Outline:Overview: targeting nanosystems to cellsAntibody targetingPeptide targetingAptamer targetingAntibodies – polyclonal and monoclonalWhere do antibodies come from – in nature?How do we make th...
ListenBME 695N Lecture 4: Designing"Theragnostic"Systems from 2007-09-04T22:37:30
Outline:Bridging the gap between diagnostics and therapeuticsHow conventional medicine is practiced in terms of diagnostics and therapeuticsThe consequences of separating diagnostics and therapeuti...
ListenBME 695N Lecture 3: Overview of Basic Nanomedical Systems Design from 2007-08-29T15:35:57
Outline:Nanomedical systems – levels of challengesEssential elements of a nanomedical systemRequirements for specific cell targetingConsequences of mis-targetingEngineering around theconsequences o...
ListenBME 695N Lecture 2: Basic Concepts of Nanomedical Systems from 2007-08-28T17:54:56
Outline: Features of NanomedicineBottoms up rather than top down approach to medicine Nano-tools on the scale of molecules Cell-by-cell repair approach – regenerative medicine Feedback control syst...
ListenBME 695N Lecture 1: Need for New Perspectives on Medicine from 2007-08-03T10:12:55
Outline:The Progression of MedicineConventional "modern" medicine "Personalized" or "molecular" medicineNanomedicine "single-cell" medicineHow Conventional Medicine Works for Diagnosis of DiseaseId...
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