Podcasts by Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 05/06

Multi-level variation in labile characters from 2022-02-22T18:00:28.637545

Labile characters, like behaviors, are phenotypes that are expressed repeatedly in the life of an individual. These types of characters allow individuals to adjust their phenotype to various levels...

Phenotypic, environmental, and genetic variation as sources of intraspecific differences in behavioral sleep in wild great tits (Parus major) from 2022-02-22T18:00:28.636482

Single-cell plasticity in mouse visual cortex following retinal lesions from 2022-02-22T18:00:28.635487

Functional characterisation and Mutational analysis of a bacterial dynamin-like protein, DynA from 2022-02-22T18:00:28.634102

Membrane remodeling is a dynamic process that occurs in bacterial cells to facilitate
substrate transport and to provide protection to bacteria during environmental stress. In
eukaryotic ...

Strukturelle und funktionale Analyse der Effektordomäne des pH-abhängigen Einkomponentensystems CadC in Escherichia coli from 2022-02-22T18:00:28.478079

Das Einkomponentensystem CadC in Escherichia coli zählt zur Gruppe der ToxR-ähnlichen Transkriptionsregulatoren und aktiviert bei niedrigem pH-Wert die Expression des cadBA-Operons, einem Säure-ind...

Charakterisierung interindividueller Strahlenempfindlichkeit in Zellen aus Tumorpatienten from 2022-02-22T18:00:28.476381

Die Strahlenempfindlichkeit des Normalgewebes ist in der humanen Bevölkerung sehr heterogen und kann bislang nicht über prädiagnostische Biomarker charakterisiert werden. Im Rahmen der vorliegenden...

Biofilm formation of the quorum sensing model organism Vibrio harveyi from 2022-02-22T18:00:28.470528

Optimierung der Identifizierungsstrategie von Proteinsignaturen aus Gewebe und Plasma from 2022-02-22T18:00:28.457149

Embryonalententwicklung des Zentralkomplexes im Gehirn der Wüstenheuschrecke Schistocerca gregaria from 2022-02-22T18:00:28.451789

Cognition through the (st-)ages from 2022-02-22T18:00:28.450736

Identification of novel candidate genes involved in individual antidepressant treatment response from 2022-02-22T18:00:28.445843

Notch2 signalling in B cell activation, immune response and lymphomagenesis from 2022-02-22T18:00:28.445004

Regulation der Autoinduktoren von Vibrio harveyi from 2022-02-22T18:00:28.373044

In Vibrio harveyi induzieren die drei Autoinduktoren (AIs) Z-3-Aminoundec-2-en-4-on CAI 1, N-(3-Hydroxybutyryl)-D-Homoserinlakton HAI 1 und der Furanosylboratdiester AI 2 die Quorum Sensing (QS) Re...

Ste20-like kinases and regulator proteins in the cytoskeleton of Dictyostelium discoideum from 2022-02-22T18:00:28.371844

The cytoskeleton in most eukaryotes consists of actin filaments, intermediate filaments, microtubules and specific associated proteins. It determines the shape and the polarity of a cell and is ine...

The LytS/LytTR-like histidine kinase from 2022-02-22T18:00:28.352550

FKBP51 at the interface of stress and psychiatric disorders from 2022-02-22T18:00:28.350716

The planar cell polarity regulator Flamingo cooperates with Netrin/Frazzled signaling during axon targeting in the Drosophila embryonic CNS from 2022-02-22T18:00:28.337645

Wie realitätsnah sind klassisch-anthropologische Proxydaten wirklich? Der Testfall einer Skelettserie aus der Zeit des demographischen Übergangs from 2022-02-22T18:00:28.329095

Während prähistorische, römische, frühgeschichtliche und mittelalterliche Skelettfunde seit jeher das Untersuchungsgut der physischen Anthropologie mit dem Ziel der Rekonstruktion von menschlicher ...

Genome engineering of the magnetosome island in Magnetospirillum gryphiswaldense from 2022-02-22T18:00:28.263291

The neuronal cell adhesion molecules NCAM and Neuroligin-2 link stress vulnerability and social behavior from 2022-02-22T18:00:28.259253

Neuronal cell adhesion molecules have recently been put into the spotlight of preclinical
and clinical research as potential candidates for the mediation of stress effects on brain
functi...

Intravitalmikroskopische Studien im Mausmodell mit kraniellen Fenstern: Fluoreszenzdarstellungen bei der Diagnostik und antiangiogenen Therapie von Gehirntumoren from 2022-02-22T18:00:28.258155

Untersuchung der strukturellen Plastizität von adult-geborenen Neuronen und deren Synapsen im Riechkolben eines Mausmodells der Parkinsonschen Erkrankung in vivo from 2022-02-22T18:00:28.247731

Das Protein ?-Synuklein (?-SYN) spielt eine kritische Rolle in der Pathogenese des Morbus Parkinson. So wird angenommen, dass die Aggregation dieses Proteins für die Degeneration von dopaminergen N...

Local adaptation of gene regulation in natural populations of Drosophila melanogaster from 2022-02-22T18:00:28.246387

The central goal of this dissertation is to understand the genetic and functional aspects of how populations adapt to new or changing environments. Genetic variation within a population, either at ...

Proteolytic modification of elastase and chemokine activities by neutrophil elastase and proteinase 3 from 2022-02-22T18:00:28.240063

Assessing the physiological and pathological functions of mast cells by the use of novel mouse models from 2022-02-22T18:00:28.233327

Molecular cytogenetics and phylogenetic modeling to study chromosome evolution in the araceae and sex chromosomes in the cucurbitaceae from 2022-02-22T18:00:28.232393

This study involved the combination of molecular-cytogenetic data and phylogenetic approaches to infer pathways by which chromosome numbers and sizes may have changed during the course of evolution...

A microRNA network in regulatory T cell differentiation from 2022-02-22T18:00:28.228917

ProNGF/NGF in humanen Granulosazellen from 2022-02-22T18:00:28.150582

Molecular phylogeny, biogeography, and an e-monograph of the papaya family (Caricaceae) as an example of taxonomy in the electronic age from 2022-02-22T18:00:28.144583

This dissertation addresses an issue of key importance to the field of systematics, namely how to foster taxonomic work and the dissemination of knowledge about species by taking full advantage of ...

Stochastic models for the ecology and population genetics of introduced species from 2022-02-22T18:00:28.071943

The long-term success of an introduced population depends on the ecological conditions in its new environment, but is also influenced by stochasticity. This is particularly clear in the first stage...

TALE nucleases as antiviral factors from 2022-02-22T18:00:28.070654

Deregulated notch and CD40 signaling in murine B lymphocytes from 2022-02-22T18:00:28.063586

The role of parental care in shaping personality-related variation in reproductive success in free-living passerines from 2022-02-22T18:00:28.062073

Integrative systematics and biogeography of Limax (Gastropoda:Stylommatophora) from 2022-02-22T18:00:28.046659

The spatial organization and regulation of triacylglycerol synthesis from 2022-02-22T18:00:28.045898

Post-translational preprotein targeting to plant organelles from 2022-02-22T18:00:28.028232

Biogeographic and cytogenetic evolution of the Alstroemeriaceae/Colchicaceae inferred from multi-locus molecular philogenies, fluorescent in situ hybridization data, and probabilistic models of geographic and chromosome number change from 2022-02-22T18:00:28.027421

Die Rolle der Checkpoint-Kinase 1 in der Immunglobulin-Diversifizierung from 2022-02-22T18:00:27.981274

Charakterisierung des Imports von Ccs1 und Pet191 in den Intermembranraum durch das Mia40-Erv1-Disulfid-Relay-System from 2022-02-22T18:00:27.970446

Transient tetraploidy as a route to chromosomal instability from 2022-02-22T18:00:27.968729

Gc9 is involved in the efficient ring assembly of the chloroplast F0F1 ATP synthase in Arabidopsis from 2022-02-22T18:00:27.966921

Functional analysis of the role of chloroplasts in senescence from 2022-02-22T18:00:27.965984

Characterization of anti-apoptotic protein family members (Bax inhibitor-1 and Lifeguard) in Hydra vulgaris from 2022-02-22T18:00:27.965051

Speciation and species delimitation in insular and continental systems from 2022-02-22T18:00:27.956904

Hintergrund
Zu den grundlegendsten Fragestellungen in der Biologie gehört die Frage nach der Natur und Entstehung biologischer Arten. Dieses Problem der Artdefinition (Engl. "Species Problem")...

Molecular diversity and phylogeny of the Calcareous Dinophytes (Thoracosphaeraceae, Peridiniales from 2022-02-22T18:00:27.940700

Mitochondrialer Proteinimport in Leishmania tarentolae und Charakterisierung der Hefeglutaredoxine 6-8 from 2022-02-22T18:00:27.935581

Heterochromatin dynamics and functions from 2022-02-22T18:00:27.934545

Regulation of centromeric and pericentric heterochromatin from 2022-02-22T18:00:27.780626

How top consumers structure food webs with multiple pathways of energy flow from 2022-02-22T18:00:27.775962

The consequences of aneuploidy in human cells from 2022-02-22T18:00:27.775109

Aneuploidy is a change in number or structure of one or more chromosomes that are not a multiple of the whole chromosome set. One of the best known pathological aneuploidies is trisomy 21 (Down syn...

CDK9 links RNA polymerase II transcription to processing of ribosomal RNA from 2022-02-22T18:00:27.771700

Interaction of genetic predisposition and epigenetic factors in the development of anxiety from 2022-02-22T18:00:27.765040

It is becoming increasingly clear by current research that the continuum of physiological anxiety up to psychopathology is not merely dependent on genes, but is orchestrated by the interplay of gen...

Psidin is required for neuron survival and axon targeting through two distinct molecular mechanisms in Drosophila from 2022-02-22T18:00:27.756358

The formation of neuronal networks depends on the proper development and targeting of the neurons within the network. One key challenge during the development of such networks is the correct cross ...

Untersuchungen von menschlichen Zellen mit ungewöhnlicher Chromatin-Anordnung und Zellkernform from 2022-02-22T18:00:27.755217

Extensive changes of higher order chromatin arrangements can be observed during prometaphase, terminal cell differentiation and cellular senescence. Experimental systems where major reorganization ...

On the way to differentiation from 2022-02-22T18:00:27.754099

Functional analysis of DOT1-dependent histone H3 lysine 76 methylation during cell cycle progression in Trypanosoma brucei from 2022-02-22T18:00:27.753325

Neural circuit analysis of the dorsal nucleus of the lateral lemniscus and new viral approaches to neural circuit analysis in Mongolian gerbils from 2022-02-22T18:00:27.731348

Auditory stimuli are processed by several parallel and serial neural circuits in the auditory brainstem. In the first part of this PhD thesis, synaptic integration of excitatory inputs in the neura...

Characterization of the membrane protein Prat1 in the inner envelope of chloroplasts from 2022-02-22T18:00:27.672674

Regulation der B-Zell-Differenzierung anhand posttranslationaler Modifikationen von Ebf1 und Untersuchungen zur Redundanz von Ebf-Proteinen from 2022-02-22T18:00:27.660356

Ecological optimization of biomass and lipid production by microalgae from 2022-02-22T18:00:27.648756

Microalgae have higher growth rates and higher lipid content than terrestrial plants and the yield per unit area is even higher by several orders of magnitude. Furthermore, the production of microa...

Structure and architecture of eisosomes from 2022-02-22T18:00:27.639223

Diversity effects on ecosystem processes from 2022-02-22T18:00:27.636534

Classification and functional characterization of extracytoplasmic function (ECF) ? factors from planctomycetes and actinobacteria from 2021-02-17T06:32:29.488762

Bacteria necessitate multiple signal transduction systems to sense the ever-changing environments and mediate the cellular response accordingly. The major bacterial signal transduction systems are ...

Signal transduction mechanisms and wiring specificity of bce-type antimicrobial peptide sensing and detoxification modules in firmicutes from 2015-09-22T12:00

Diversity, molecular phylogeny, ecology and distribution of the genera Lactifluus and Lactarius (Russulales, Basidiomycota) in West Africa from 2015-08-14T12:00

Breaking symmetry from 2015-07-30T12:00

Polarity is a fundamental feature of almost all cells. It generally refers to the asymmetric organization of several cellular components. The plasma membrane, for example, exhibits both a transbila...

Untersuchung der gesteigerten Zytotoxizität von Trabectedin durch Hyperthermie in Tumorzellen from 2015-07-28T12:00

Adulte Weichgewebesarkome (engl. soft tissue sarcoma; STS) werden zu einer Gruppe seltener maligner und teilweise aggressiver Tumoren klassifiziert, die eine Tendenz zur Bildung von hämatogenen Fer...

The phylotypic stage of Zebrafish from 2015-07-24T12:00

The phylotypic stage, as part of the embryonic period, is the stage where embryos of
different species of a phylum show a high degree of similarity.
Johann Friedrich Meckel, Karl Ernst vo...

Testing traditional concepts from 2015-07-24T12:00

Immunmodulatorische Aktivität von Überständen probiotischer Bakterien und dem darin enthaltenen D-Tryptophan from 2015-07-22T12:00

Eph-Rezeptoren, Ephrine und Notch bei der Ausbildung von Gewebegrenzen in Hydra from 2015-06-24T12:00

Architecture of SMC-kleisin complexes from 2015-06-11T12:00

In all cellular systems, the transmission of bulk genetic information during proliferation occurs in the form of chromosomes. The segregation of these entities upon cell division is of pivotal impo...

Triops-induced morphological defences in Daphnia magna from 2015-05-20T12:00

Characterization of the Dpb11-Slx4 Complex and its role in DNA repair from 2015-05-18T12:00

Stimulus-dependent glucocorticoid receptor signalling in early-life stressed mice from 2015-05-18T12:00

Epigenetic programming facilitates the adaptation of an organism to changes in the environment through lasting alterations in gene expression that underlie certain physical and behavioral phenotype...

Genetics of human sleep EEG from 2015-05-12T12:00

Sleep characteristics are candidates for predictive biological markers in patients with severe psychiatric diseases, in particular affective disorder and schizophrenia. The genetic components of sl...

Proliferation and arrest of human tetraploid cells from 2015-04-24T12:00

Durch Fehler entstandene tetraploide Zellen sind chromosomal instabil und können zu Zelltransformation führen. Die Beweise verdichten sich, dass die Propagation von tetraploiden Säugetierzellen dur...

Natural history, taxonomy, biogeography and genome evolution of the worldwide endoparasite family Apodanthaceae (Cucurbitales) from 2015-04-17T12:00

Lokalisierung und Charakterisierung Calmodulin-ähnlicher Proteine aus Arabidopsis thaliana from 2015-04-16T12:00

Real-time imaging of hippocampal network dynamics reveals trisynaptic induction of CA1 LTP and "circuit-level" effects of chronic stress and antidepressants from 2015-04-15T12:00

Today’s pervasive presence of stress renders stress-related psychiatric disorders (SRPDs), a relevant global health problem. Memory impairment is a major symptom likely mediated by the hippocampus ...

Genomweite Assoziationsstudien mit metabolischen Merkmalen aus Kernspinresonanz (NMR) Spektroskopie from 2015-04-15T12:00

Engineering and screening of genetically encoded FRET Calcium indicators from 2015-04-13T12:00

Fluorescent protein sensors have gained great importance in research as they exhibit a number of advantages over synthetic dyes. They can be targeted precisely, large populations of cells can be im...

RNA-Seq-basierte Isolierung des Resistenzgens Bs4C aus Paprika from 2015-04-13T12:00

Das Paprika Resistenzgen Bs4C aus Capsicum pubescens vermittelt Resistenz gegenüber Xanthomonas campestris pv. vesicatoria (Xcv)-Stämmen, die den (transcription activator-like) TAL-Effektor AvrBs4 ...

Funktionelle Analyse der PCNA-Polyubiquitinierung und der E3-Ligase SHPRH from 2015-03-16T12:00

Environmental and social modulation of hormones and behavior in a free living songbird, the black redstart from 2015-03-13T12:00

Identification of Roquin-regulated mRNAs in T helper cells and molecular characterization of the Roquin-RNA interaction from 2015-03-13T12:00

Biological role and genetic redundancy within the ebf gene family from 2015-03-10T12:00

Molecular view on the spatiotemporal organization of Bacillus subtilis subcellular compartments from 2015-03-10T12:00

All living cells are highly organized and exhibit complex cellular machineries facilitating biochemical reactions. Compartmentalization is a prerequisite to allocate an appropriate environment for ...

Cell-cell communication via LuxR solos in Photorhabdus species from 2015-02-27T12:00

Bacteria constantly need to monitor their environment and adapt the bacterial group-coordinated behaviour to changing habitats like nutrition alterations or host variations. Commonly cell-cell comm...

Screening anti-prion compounds and diagnosing prion diseases by amplifying PrPSc in vitro from 2015-02-24T12:00

Studies on polar cell wall growth and antibiotic susceptibility of Corynebacterium glutamicum from 2015-02-19T12:00

Corynebacterium glutamicum is a Gram positive soil bacterium with high industrial importance in ton scale production of amino acids. Apart from that, it becomes more and more important for medical ...

Distinction of vasculitis-associated ANCA subsets and their pathogenic role in a new mouse model with the humanized target antigen from 2015-02-18T12:00

Compatibility benefits of social and extra-pair mate choice in the zebra finch from 2015-01-29T12:00

Behavioural ecologists aim at providing insights into the evolutionary and ecological processes that shape animal behaviour. Mate choice is a decision faced by most animals that can strongly affect...

A dedicated mechanism for DNA-protein crosslink repair from 2015-01-21T12:00

Functionalization of bacterial magnetic nanoparticles by genetic engineering and encapsulation with inorganic coatings from 2015-01-16T12:00

Role and regulation of TET-mediated DNA modifications in gene expression from 2014-12-19T12:00

In the mammalian genome, cytosine methylation (5mC) plays a central role in the epigenetic regulation of gene expression and has been implicated in a variety of biological processes, including geno...

Einzelzell-Analyse unkultivierter magnetotaktischer Bakterien from 2014-12-15T12:00

Proxies of extra-pair behaviour from 2014-12-15T12:00

Viele Vogelarten sind monogam, aber es kommt zugleich häufig zu Paarungen außerhalb des Paarbundes (Griffith et al. 2002). In einer großen Zahl von Studien wurde bereits der adaptive Wert der aus d...

Insects as a model to puzzle out mechanisms of lineage diversification in the Indomalayan / Australasian archipelago from 2014-12-12T12:00

R programming in phylogenetics and evolution from 2014-12-11T12:00

This dissertation addresses the application of the statistical computing language
R in the study of evolution and diversification of plants. The topics included
range from the worldwide h...

Sensorimotor postural control in healthy and pathological stance and gait from 2014-12-10T12:00

Postural control during standing and walking is an inherently unstable task requiring the interaction of various biomechanical, sensory, and neurophysiological mechanisms to shape stable patterns o...

The development and molecular characterization of muscle spindles from wildtype and mutant mice from 2014-11-27T12:00

Muscle spindles are complex stretch-sensitive mechanoreceptors that consist of 4-12 specialized muscle fibers. These intrafusal muscle fibers are innervated in the central (equatorial) region by an...

Expression quantitative trait loci as possible biomarkers on depression from 2014-11-26T12:00

Investigations on the role of Hsp90 in the pathogenic glucocorticoid resistance of corticotroph pituitary adenomas from 2014-11-20T12:00

The main function of glucocorticoids in corticotroph cells is to suppress proopiomelanocortin, the precursor of the stress hormone adrenocorticotropin (ACTH). Cushing’s disease is a rare but severe...

Funktion des Lysintransporters LysP von Escherichia coli in Transport und Regulation from 2014-11-20T12:00

Identification and characterization of novel Drosophila melanogaster centromere-associated proteins from 2014-11-19T12:00

Establishment of photosynthetic complexes in the chloroplast from 2014-11-18T12:00

The characterization of actin variants in Dictyostelium discoideum from 2014-11-17T12:00

Characterization of the Lotus Japonicus nuclear pore NUP107-160 subcomplex in plant-microbe symbiosis from 2014-11-17T12:00

Identification and manipulation of molecules regulating axonal outgrowth and synapse formation during post-injury axonal remodeling from 2014-11-12T12:00

Analysis of Dscam1 diversity in regulating dendritic morphology of Lobula Plate Tangential Cells from 2014-11-11T12:00

In arthropods like Drosophila, Down syndrome cell adhesion molecules (Dscam1) exhibit enormous molecular diversity. A single Dscam1 gene encodes a large superfamily of neuronal cell recognition pro...

Systematic analysis of lysine acetyltransferases from 2014-10-28T12:00

Characterization of the protein import pathway in pea chloroplast from 2014-10-27T12:00

In order to sustain their structure and metabolism, chloroplasts and other plastid types
must import the majority of their proteins from the cytosol across the envelope membrane. Translocation...

Characterization of a sensory complex involved in antimicrobial peptide resistance from 2014-10-24T12:00

In their habitats, microorganisms are often in competition for limited nutrients. In order to succeed,
many Gram-positive bacteria resort to production of peptide antibiotics. Therefore, resis...

Visual system of basal Chelicerata from 2014-10-22T12:00

Neural circuits underlying colour vision and visual memory in Drosophila melanogaster from 2014-10-15T12:00

Focusing at the fly visual system I am addressing the identity and function of neurons
accomplishing two fundamental processing steps required for survival of most animals: neurons of peripher...

Neural circuits mediating aversive olfactory conditioning in Drosophila from 2014-10-14T12:00

For all animals it is highly advantageous to associate an environmental sensory stimulus with a reinforcing experience. During associative learning, the neural representation of the sensory stimulu...

A new circuit for visual memory formation from 2014-10-14T12:00

Kinetic properties of heteromeric kinesin-2 from Caenorhabditis elegans from 2014-10-13T12:00

Sensing and retrograde signalling of mitochondrial metabolic states in plants from 2014-09-26T12:00

Wechselwirkung immunmodulatorischer Zellen mit vaskulären Endothelzellen from 2014-09-22T12:00

The role of ORC6 in the human cell from 2014-09-19T12:00

Orc6 is a crucial component of the replication initiation machinery in eukaryotes. Its study helps us to better understand one of the most basic cell functions: DNA replication.
The first step...

Developmental adaptations of energy and lipid metabolism in Trypanosoma brucei insect forms from 2014-09-18T12:00

Continuous quantification of transcription factor dynamics in individual hematopoietic stem and progenitor cells from 2014-09-11T12:00

Proteomic analysis of specific chromatin domains containing the histone variants H2A.Bbd and macroH2A.1.2 from 2014-07-31T12:00

Remorin proteins in Arabidopsis thaliana from 2014-07-31T12:00

Die Plasmamembran lebender Zellen stellt die Hauptbarriere fu?r alle Arten von
extrazellulären Signalen dar. Viele davon werden ins Innere der Zelle weitergeleitet, hier
lösen sie im Kern...

Die Bedeutung des Transkriptionsfaktors Sox2 für die Entwicklung des Kleinhirns und die Entstehung von Medulloblastomen from 2014-07-31T12:00

Morphology and evolution of Malacostraca from 2014-07-30T12:00

In this dissertation project comparative morphological studies on the nervous system, mandible
structure and sensory equipment of Decapoda and Peracarida are presented and interpreted with <...

Characterization of H3K56me3, a novel histone core modification from 2014-07-29T12:00

Evolution of genes related to temperature adaptation in Drosophila melanogaster as revealed by QTL and population genetics analyses from 2014-07-21T12:00

The fixation of beneficial variants leaves genomic footprints characterized by a reduction of genetic variation at linked neutral sites and strong, localized allele frequency differentiation among ...

Transfer humanpathogener Bakterien auf Salat und Gemüse bei biologischem Anbau from 2014-07-21T12:00

Transport of metabolites in chloroplasts from 2014-07-15T12:00

Analysis of spine plasticity in CA1 hippocampal pyramidal neurons employing live cell nanoscopic imaging from 2014-07-14T12:00

In der Großhirnrinde von Säugetieren be?ndet sich die Mehrheit erregender Synapsen auf Dornfortsätzen, kleinen dendritischen Ausbuchtungen, die in Größe und Form stark variieren. Die Auslösung akti...

Evolution of the wild tomato species Solanum chilense from 2014-07-10T12:00

Demography and adaptation are important factors determining the evolution of plant species. Many plant species are substructured into populations or demes connected by migration (metapopulations). ...

Neural circuits underlying CO2 behavior in Drosophila melanogaster from 2014-06-30T12:00

Gene-environment interplay of extreme anxiety-related behavior from 2014-06-26T12:00

The use of selectively bred mouse models of enhanced fear and/or anxiety-related behavior provides a unique opportunity to identify genetic targets that contribute to pathological anxiety. However,...

Integrative taxonomy of decapod crustaceans with traditional and modern methods from 2014-06-24T12:00

Die als Zehnfußkrebse oder auch als Decapoda bezeichneten Arthropoden sind eine weltweit verbreitete, zum Teil hoch spezialisierte und vielseitig angepasste Gruppe, die in fast allen aquatischen Ök...

Regulation of pituitary growth hormone synthesis by NAD+ dependent deacetylase Sirt1 from 2014-06-24T12:00

Untersuchungen zum Genom und dem immunologisch aktiven D-Tryptophan im probiotischen Lactobacillus casei W56 im Vergleich mit anderen probiotischen Lactobacillen from 2014-05-22T12:00

Synaptische Pathologie in Tau-transgenen Mausmodellen neurodegenerativer Erkrankungen from 2014-05-13T12:00

In Zeiten des demografischen Wandels erfahren Krankheiten wie die Alzheimer-Demenz, als deren größter Risikofaktor das Alter gilt, einen rasanten Anstieg der Patientenzahl. Die Erforschung der zugr...

Dissecting the dynamics of DNA methyltransferase 1 and related nuclear proteins in living cells from 2014-04-30T12:00

The calcium signature decoding CCaMK/CYCLOPS complex activates the transcription of symbiosis associated genes from 2014-04-29T12:00

Heterogenität humaner SHH-assoziierter Medulloblastome from 2014-04-29T12:00

The neuronal basis of zebrafish olfactory imprinting from 2014-04-15T12:00

Optical dissection of amygdalar network dynamics related to stress, anxiety, and pharmacological treatment from 2014-04-10T12:00

Tracing evolution from 2014-04-10T12:00

Oxygen regulation and redox control of magnetosome biomineralization in Magnetospirillum gryphiswaldense from 2014-03-25T12:00

Morphologische Verteidigungen und Temperaturtoleranz als Schlüsselfaktoren für die erfolgreiche Invasion von Daphnia lumholtzi in Nordamerika from 2014-03-18T12:00

The role of horizontal system cells in optomotor responses in Drosophila melanogaster from 2014-03-17T12:00

When confronted with a large-field stimulus rotating around the vertical body axis, flies display a following behaviour of the head and steer in the direction of motion. As neural control elements ...

Studies of mechanisms regulating Tet proteins from 2014-03-14T12:00

Mikroevolution und Geschichte der Pest from 2014-02-26T12:00

Diese Arbeit beschäftigt sich mit der Erforschung von Yersinia (Y.) pestis in historischem Skelettmaterial. Die Disziplin Paläomikrobiologie verspricht, Beweise zu liefern, die durch die Erforschun...

Targeting the heat shock protein 90 with the novel small-molecule inhibitor NW457 sensitizes tumor cells to ionizing radiation from 2014-02-25T12:00

Proteomics of newly assembled chromatin from 2014-02-25T12:00

Dlg1 is required for myofibrillar arrangement in the Drosophila heart from 2014-02-24T12:00

Differential modes of Eph signaling in olfactory dendrite targeting of Drosophila from 2014-02-24T12:00

Dissecting the role of selenothiol- versus thiol-based catalysis using the model enzyme glutathione peroxidase 4 (GPx4) from 2014-02-14T12:00

Selenocysteine (Sec) is the 21st amino acid. Unlike other amino acids incorporation of Sec into proteins is more complex by far as it is encoded by the opal stop codon UGA. A complex and highly sop...

Investigation of the biochemistry and function of neutrophil serine protease 4 (NSP4) from 2014-01-31T12:00

Serine proteases in cytoplasmic granules of neutrophils (NSPs), namely neutrophil elastase, cathepsin G (CG) and proteinase 3, have been under intense investigation for several decades. They are ma...

Die Rolle von GSK-3? in der strukturellen Spine-Plastizität from 2014-01-27T13:00

Expression of higher plant photosynthetic proteins in the cyanobacterium Synechocystis sp. PCC 6803 from 2014-01-23T12:00

Genetic and functional characterization of candidate genes for complex psychiatric diseases using next-generation sequencing and cellular uptake assays from 2014-01-22T12:00

Complex phenotypes are the result of a complex interplay between genes and environmental factors. Extensive linkage, candidate and genome-wide association studies (GWASs) have been carried out to u...

Visualization and targeted disruption of protein interactions in living cells from 2014-01-17T12:00

Development of a CENH3-based and non-viral vector system from 2014-01-14T12:00

New vectors for successful transgene delivery in patients are more than needed. Current gene therapeutic vectors are mostly based on virus genomes. A main reason is the very efficient administratio...

Identifikation und Charakterisierung niedermolekularer MALT1 Inhibitoren zur Therapie von ABC-DLBCL from 2014-01-13T12:00

Integrative taxonomy of antarctic and subantarctic sea spiders (Pycnogonida) using morphological and molecular methods from 2013-12-19T12:00

Intratumorale T-Zellen in einem Spontanlymphommodell der Maus from 2013-12-19T12:00

Es gibt zahlreiche Bemühungen, neue Immuntherapien zur Behandlung von malignen Tumoren zu entwickeln, da die Prognose vieler Krebserkrankungen immer noch schlecht ist. Dazu muss das Verständnis, wi...

Modeling the demographic history of Drosophila melanogaster using Approximate Bayesian Computation and Next Generation Sequencing Data from 2013-12-18T12:00

The main goal of this thesis was to develop demographic models of the fruit fly Drosophila melanogaster using Approximate Bayesian Computation and Next Generation Sequencing Data. These models were...

Genome-wide analysis of innate electric shock- and odour-avoidance, punishment- and relief- learning from 2013-12-13T12:00

Insights into the RNA Polymerase CTD code from 2013-12-12T12:00

3D-Neuroanatomie und Feinstruktur nervöser Verschaltungen im Sehsystem von Tintenfischen (Cephalopoda) from 2013-12-10T12:00

Analysis of the Barr body with super-resolution microscopy from 2013-11-22T12:00

X chromosome inactivation (XCI) in female mammalian cells is an ideal model system to study the relationship of epigenetic regulation and higher-order chromatin structure. However, light microscopi...

Homer has the Blues from 2013-11-21T12:00

Die Rolle des NF-kappaB Signalwegs in LMP1/CD40-exprimierenden B-Zellen in vivo from 2013-11-20T12:00

Die Charakterisierung von DDX27 als nukleolärer Ribosomenbiogenesefaktor und Interaktionspartner des PeBoW-Komplexes from 2013-11-14T12:00

Genome-wide identification of nucleosome positioning determinants in schizosaccharomyces pombe from 2013-11-12T12:00

Principles of protein group SUMO modification substantiated in DNA repair from 2013-10-29T12:00

Posttranslational modifications (PTMs) of proteins by covalent attachment of functional groups (like phosphorylation, acetylation, methylation, glycosylation, etc.) are of key importance for the ce...

Charakterisierung der in vivo Wachstumskinetik amyloider Plaques und der synaptischen Pathologie mit Evaluierung eines immuntherapeutischen Ansatzes in einem Alzheimer-Mausmodell from 2013-10-22T12:00

Morbus Alzheimer ist die häufigste Form einer Demenzerkrankung und stellt aufgrund der steigenden Lebenserwartung eine sehr große ökonomische und emotionale Belastung für Patienten, deren Familien ...

Role of regulatory T cells in experimental autoimmune encephalomyelitis from 2013-10-15T12:00

Beauveria bassiana infection in Drosophila melanogaster from 2013-10-15T12:00

Drosophila melanogaster is a model organism to study innate immunity in invertebrates. Temperate and tropical D. melanogaster populations, being exposed to different environments, potentially face ...

Einfluss eines Carboanhydrase XII-spezifischen Antikörpers auf das Tumorwachstum in vitro und in vivo sowie Onkosomen-basierte Generierung neuer tumorreaktiver Antikörper from 2013-10-14T12:00

In dieser Arbeit wurden Mikrovesikel, die von Tumor-Zelllinien in hohen Konzentrationen sekretiert wurden, zur Immunisierung von Ratten verwendet, um auf diese Weise monoklonale Anti-körper gegen m...

A screen to identify factors in translation-dependent retrograde signaling from 2013-09-30T12:00

Cross-talk of genetically and environmentally modulated epigenetic factors in the development of anxiety-related behavior from 2013-09-26T12:00

Here, I studied the role of two candidate genes i.e. neuropeptide S receptor 1 (Npsr1) and transmembrane protein 132D (Tmem132d), in two psychopathological animal models of anxiety-related behavior...

Molecular and physiological dissection of GUN1 chloroplast-to-nucleus retrograde signaling from 2013-09-26T12:00

Intrinsic and extrinsic regulation of receptor tyrosine kinase signaling for axon growth and guidance from 2013-09-18T12:00

Arbuscular mycorrhizal fungi for reforestation of native tropical trees in the Andes of South Ecuador from 2013-09-17T12:00

WH2 domains and actin variants as multifunctional organizers of the actin cytoskeleton from 2013-09-16T12:00

Actin is one of the most abundant proteins in eukaryotic cells and regulation of the microfilament system is crucial for a wide range of cellular functions including cell shape, cell motility, cell...

Monitoring homology search during DNA double-strand break repair in vivo from 2013-09-12T12:00

Visualizing T cell activation around the blood-brain barrier Dissertation from 2013-07-23T12:00

T cells recognizing myelin auto-antigens penetrate into the CNS to induce inflammatory autoimmune disease following complex sequential interactions with individual components of the vascular blood-...

Aktivierung des FLT3-Signalweges als molekulare Zielstruktur in der akuten myeloischen Leukämie from 2013-07-22T12:00

Serielle Analyse stabiler Isotope an Haarkeratin zur post mortem Rekonstruktion von Lebenslaufparametern in forensisch relevanten Fällen von Unterernährung from 2013-07-22T12:00

Die Diagnose einer Unterernährung bei Kindern und Erwachsenen ist in der Pädiatrie
und Geriatrie ein wichtiges Thema. Aber auch in der Forensik spielt sie eine große Rolle,
gerade im Fall...

Erstellung und Analyse von TALE-Transkriptionsfaktoren mit benutzerdefinierter Erkennungsspezifität from 2013-07-19T12:00

Charakterisierung von Mechanismen der Antigenprozessierung für die Präsentation auf MHC-Klasse-I from 2013-07-10T12:00

Conditional in vivo expression of the fusion kinase ITK-SYK from 2013-06-25T12:00

The role of elongation factor EF-P in translation and in copy number control of the transcriptional regulator CadC in Escherichia coli from 2013-06-19T12:00

Enterobacteria have evolved several strategies to survive the acidic environment of the gastrointestinal tract. One of the acid stress resistance systems is the Cad system in Escherichia coli, whic...

On the trail of anxiety from 2013-06-18T12:00

With the advances in genome wide screening arrays and sequencing techniques scientists were enabled to examine genetic variations and their effects on behavioral phenotypes. While single nucleotide...

Functional analysis of two components of the chloroplastic TIC complex from 2013-06-18T12:00

Function and significance of the putative Na+/solute symporter PutP of Helicobacter pylori from 2013-06-17T12:00

Generation and characterization of heavy chain antibodies derived from Camelids from 2013-06-13T12:00

Antibodies and antibody fragments are essential tools in basic research, diagnostics and therapy. Conventional antibodies consist of two heavy and two light chains with both chains contributing to ...

Roquin family proteins control T cell co-stimulation and differentiation from 2013-06-11T12:00

The LiaFSR three-component System of Bacillus subtilis from 2013-05-23T12:00

Soil bacteria are exposed to constant changes in temperature, moisture, and oxygen content. Additionally, they have to encounter different antimicrobial substances, which are produced by competing ...

Monitoring restoration and aboveground biomass in tropical peat swamp forests on Borneo using multi-sensoral remote sensing data from 2013-05-21T12:00

Characterization of the actin-like MreB cytoskeleton dynamics and its role in cell wall synthesis in Bacillus subtilis from 2013-05-13T12:00

The peptidoglycan cell wall (CW) and the actin-like MreB cytoskeleton are the majordeterminants of cell morphology in non-spherical bacteria. Bacillus subtilis is a rod-shaped Grampositive
bac...

Diversity and morphology of calcareous dinophytes (Thoracosphaeraceae, Peridiniales) from 2013-04-26T12:00

Dinophytes are unicellular eukaryotic algae that, together with their closest relatives, ciliates
and apicomplexans, belong to the superphylum of alveolates. Some of them, namely
calcareo...

Anthropologie einer frühstädtischen Randgruppe from 2013-04-25T12:00

Etablierung der Interaktion des viralen Onkoproteins LMP1 mit den zellulären Signalproteinen der TRAF-Proteinfamilie als Zielstruktur für Inhibitoren from 2013-04-22T12:00

Das Epstein-Barr Virus (EBV) ist mit einer Reihe von lebensbedrohlichen Krankheiten assoziiert. Dazu zählen unter anderem Nasopharynxkarzinome, Hodgkin-Lymphome und lymphoproliferative Erkrankungen...

Pathologische Veränderungen in den Retinae transgener Mausmodelle des Morbus Alzheimer und deren diagnostische Relevanz für den Menschen from 2013-04-17T12:00

Morbus Alzheimer ist die am weitesten verbreitete Form der Demenz mit verheerendem Einfluss auf das Leben der Betroffenen, deren Angehörigen sowie die weltweiten Sozialsysteme. Durch die alternde G...

Golden goal regulates target specificity in the Drosophila Lamina from 2013-04-12T12:00

In the visual system of Drosophila, photoreceptor (R) neurons elaborate a precise retinotopic map of visual space in the brain. The retina consists of 750 ommatidia, each containing eight photorece...

Comparative 3D microanatomy and systematics of skeneimorph gastropods, with a survey on epipodial tentacles in lower gastropods from 2013-03-26T12:00

STN7/8 from 2013-03-20T12:00

Correlated plasticity of synaptic structures and its relationship to the stabilization of synaptic enlargement from 2013-03-18T12:00

The ability to adapt to environmental changes, to learn and to memorize
information is one of the brain’s most extraordinary features. One important
process underlying this ability is con...

Untersuchungen zur Autophagie-abhängigen Präsentation intrazellulärer Antigene auf MHC-Klasse-II from 2013-03-12T12:00

Revision of the substrate brooding “Tilapia (Tilapia Smith, 1840 and related taxa), (Teleostei: Perciformes: Cichlidae) from 2013-02-25T12:00

Identifizierung von Inhibitoren der Notch- oder EBNA2-vermittelten Transaktivierung von Zielgenen from 2013-02-25T12:00

Metalltranslocon - Komplexe in Chloroplasten from 2013-02-12T12:00

Molecular dissection of Pax6 DNA-binding domains and their roles in mouse cerebral cortex development from 2013-01-31T12:00

Generation of the brain depends on proper regulation of progenitor proliferation and differentiation during development. Many such factors known to affect proliferation and differentiation are tran...

Identification and characterization of glomeromycotan ammonium transporters from 2013-01-30T12:00

Role of the AAA protease Yme1 in folding of proteins in the mitochondrial intermembrane space from 2013-01-29T12:00

The vast majority of mitochondrial proteins are encoded in the nucleus and synthesized as precursor proteins on cytosolic ribosomes. After translation, these precursor proteins are imported in a la...

In vitro direct conversion of somatic cells from the adult human brain into functional neurons by defined factors from 2013-01-28T12:00

Reprogramming of somatic cells into neurons provides a new approach toward cell-based therapy of neurodegenerative diseases. Conversion of postnatal astroglia from the cerebral cortex of mice into ...

Role of sensory input in structural plasticity of dendrites in adult neuronal networks from 2013-01-17T12:00

So happy together from 2013-01-17T12:00

Lokalisierung und Charakterisierung der AAA+-Proteine AFG1L2 und AFG1L1 aus Arabidopsis thaliana from 2012-12-14T12:00

Das Kalzium Signalnetzwerk ist ein wichtiger Übermittler von internen und externen Reizen in der Pflanze. Diese Signale werden unter anderem durch Calmodulin und calmodulin ähnlichen Proteine an ve...

Molecular systematics and historical biogeography of Araceae at a worldwide scale and in Southeast Asia from 2012-12-14T12:00

This dissertation addresses the biogeographic history of the Araceae family and of one of its largest genera, Alocasia. With >3300 species, Araceae are among the largest families of ?owering plants...

Insights into stimulus perception, target gene expression and network formation of LytS/LytTR-like histidine kinase/response regulator systems in Escherichia coli from 2012-12-14T12:00

Biochemical characterization of an intermediate membrane subfraction in cyanobacteria involved in an assembly network for photosystem II from 2012-12-12T12:00

Oxygenic photosynthesis converts light energy into chemical energy and is responsible for generating most of our atmosphere’s oxygen and biomass on earth. Several multimeric protein complexes are i...

Interspecies interaction and diversity of green sulfur bacteria from 2012-12-11T12:00

The following work is shedding light on the phylogenetic classification on the family of the Chlorobiacea, the members of which are showing signs of preadaptation to symbiosis. Symbioses consisting...

The startle response as a measure in mouse models of mood disorders from 2012-12-11T12:00

Ein großer Teil der Fragestellungen in den Neurowissenschaften beschäftigt sich mit dem Thema, wie das Säugerhirn Verhalten auslöst und steuert. Die Schreckreaktion ist ein relativ einfaches Verhal...

Heterogeneity and timing in the quorum sensing system of Vibrio harveyi from 2012-12-10T12:00

Bacteria produce and excrete signaling molecules, so called autoinducers, which allow them to monitor their population density and/or their environment in a process best known as quorum sensing. Th...

The role of Ebf2 in normal and malignant hematopoiesis from 2012-11-30T12:00

Encoding of saccadic scene changes in the mouse retina from 2012-11-27T12:00

The task of the visual system is to extract behaviourally relevant information from the visual scene. A common strategy for most animals ranging from insects to humans is to constantly reposition g...

Innovations in rabies virus rescue from 2012-11-26T12:00

Behavioural and hormonal aspects of the breeding ecology in sex-role reversed polyandrous birds from 2012-11-19T12:00

Das Phagenschock-Protein LiaH aus Bacillus subtilis from 2012-10-31T12:00

Für das Überleben von Bacillus subtilis ist eine verlässliche Überwachung der Integrität
der Zellhülle essentiell, um diese zu schützen und bei Schäden adäquat zu reagieren.
Neben den ECF...

The role of DNA modifications in pluripotency and differentiation from 2012-10-30T12:00

DNA methylation plays a crucial role in the epigenetic control of gene expression during
mammalian development and differentiation. Whereas the de novo DNA methyltransferases
(Dnmts), Dnm...

Systematics and evolution of the Acochlidia (Gastropoda, Euthyneura) - a microanatomical approach by means of 3D reconstruction using Amira from 2012-10-25T12:00

Only a small fraction of the estimated species diversity on Earth already has been discovered, and expected high extinction rates force biologists to rapid surveys. Molecular barcoding techniques m...

Identi cation of novel molecular factors involved in individual stress vulnerability from 2012-10-25T12:00

Stress is part of everyday life. And while acute and short periods of stress can help to overcome challenges, exposure to chronic - and especially uncontrollable - stress can lead to maladaption of...

Phylogenetic and functional analyses of stress-responsive bacterial transmembrane signal transducing systems from 2012-10-24T12:00

Biogenese des Rieske-Eisen-Schwefel-Proteins der Mitochondrien from 2012-10-22T12:00

CTCF, Lamin A/C und eine Histondeacetylase sind essentiell für die Positionierung des humanen CFTR-Gens an der Zellkernperipherie from 2012-10-19T12:00

Zac1 kontrolliert die astrogliale Differenzierung durch Socs3 from 2012-10-19T12:00

Brain circuit dynamics related to extremes in trait anxiety in mice from 2012-10-17T12:00

Anxiety disorders are among the most common psychiatric diseases and contribute to the development of other psychiatric conditions, such as major depression, leading to a high impairment of daily l...

Central and peripheral aspects of hypothalamic-pituitary-adrenal (HPA) axis dysfunction from 2012-10-17T12:00

An aberrant regulation of the hypothalamic-pituitary-adrenal (HPA) axis is closely associated with the pathophysiology of affective disorders such as major depression (MD). Accordingly, patients su...

Studies on the release of neutrophil extracellular traps and IFN-? as part of the innate immune response to Aspergillus fumigatus and on the fungal stress response via the hybrid sensor kinase TcsC from 2012-10-16T14:00

Aspergillus fumigatus is a saprophytic mold that naturally inhabits the soil. Asexual reproduction yields hardy conidia that circulate in the air and are inhaled daily by humans. The fungus seems n...

Anpassung von Pseudomonas aeruginosa an die Mukoviszidose-Lunge from 2012-09-27T12:00

Rapid neuronal signaling cascades initiated by corticosterone from 2012-09-25T12:00

Besides inducing transcription by activating nuclear receptors, corticosterone (CORT) acts rapidly to alter cellular activity through multiple signaling cascades. Pharmacology-based experiments pre...

Tcf4 is a target gene of the imprinted gene Zac1 during mouse neurogenesis from 2012-09-18T12:00

Identification of MLL-A9 related target genes and microRNAs involved in leukemogenesis from 2012-09-17T12:00

The source of innervation and function of palisade endings in the extraocular muscles of Macaca mulatta from 2012-09-12T12:00

Vertebrate extraocular muscles show a highly complex anatomy, which differs in many respects from skeletal muscles. Furthermore, there is a considerable variation among different species with regar...

The Arabidopsis MTERF protein PAM48 is required for plastid gene expression and development from 2012-09-12T12:00

Characterization of two chloroplast envelope membrane proteins from 2012-08-27T12:00

Characterization of PratA and Tic22 proteins for functions in membrane biogenesis in Synechocystis sp. PCC 6803 from 2012-08-24T12:00

Development of techniques for single dendritic spine analysis from 2012-07-31T12:00