Outcomes of UTERUS-11 Trial with Christhardt Köhler and Simone Marnitz-Schulze - a podcast by BMJ Group

In this episode of the IJGC podcast, Editor-in-Chief, Dr. Pedro Ramirez, is joined by Dr. Simone Marnitz-Schulze and Dr. Christhardt Köhler to discuss the outcomes of UTERUS-11 Trial. Drs. Marnitz-Schulze and Köhler are authors of “Surgical versus Clinical Staging prior to primary Chemoradiation in Patients with Cervical Cancer FIGO Stages IIB-IVA: Oncologic Results of a Prospective Randomized International Multicentre (Uterus-11) Intergroup Study,” which is the Lead Article of the December 2020 issue of the International Journal of Gynecological Cancer.

Highlights:-Surgical staging prior to chemoradiation in locally advanced cervical cancer is safe, feasible, does not delay chemoradiation
-Lead to an upstaging in 33% of the patients-Resulted into a statistically significant improvement of DFS in FIGO stage IIB patients
-Resulted into a trend for improved OS and DFS for all subgroups

-Because of high rates of distant metastases, systemic treatment has to be intensified

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