Podcasts by Journal of Clinical Oncology (JCO) Podcast

Characterizing the Patterns of Clonal Evolution in Ibrutinib-Treated CLL: A Roadmap for Continued Progress from 2017-02-13T21:00

Dr. Wiestner highlights characteristics of ibrutinib resistant CLL as reported by Woyach and colleagues and discusses how these data refine the management of CLL in the area of targeted therapy ...

Prevalence of Germline Mutations in Individuals With Colorectal Cancer as Determined Using a Multi-Gene Panel Test from 2017-01-30T21:00

Summary and discussion of JCO paper by Yurgelun at al. using a 25-gene panel to demonstrate a nearly 10% germline mutation rate in colorectal cancer patients independent of high-risk fa...

Financial Barriers to Cancer Care for Patients Obtaining Insurance on the Federal Exchange from 2017-01-11T19:06:49

By Stacie B. Dusetzina

Considering the role of network coverage on access to accredited cancer institutions and potential out-of-pocket costs for patients.

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Mindfulness-Based Interventions in Oncology: Not for Everyone? from 2016-11-21T18:19:33

By Linda E. Carlson

This podcast discusses the target study in the context of other research on mindfulness-based interventions for cancer patients and survivors, providing a cri...

The Impact of Oral Targeted Therapies on the Cost of Care for Patients With Chronic Lymphocytic Leukemia from 2016-11-21T18:15:19

By Christopher R. Flowers

Modeling studies like the one presented by Qiushi Chen and colleagues can project where needs and opportunities exist to address the pricing structure o...

Watching Nivolumab’s Balancing Act: How Immune Activation May Affect Both Safety and Efficacy in Patients With Advanced Melanoma from 2016-11-14T21:00

This podcast provides commentary on a large dataset describing the expected frequency, severity and kinetics of immune-related adverse events associated with nivolumab monotherapy and the expect...

Getting to the Heart of the Matter: Biomarkers for the Assessment of Trastuzumab-Induced Cardiac Dysfunction from 2016-10-26T20:00

By Deepa Rangachari

This podcast focuses on the use of trastuzumab in adjuvant therapy for early stage, Her2-positive breast cancer and ongoing efforts to identify predictive and...

Listen to Your Patients from 2016-10-03T20:00

If you are an oncologist and think that it isn’t part of your job to listen to your patients talk about depression, I urge you to re-consider.  As Sullivan and colleagues show, depression can be...

Impact of Organizational Characteristics and Process of Care on Hospital Mortality and Resource Use in Cancer Patients Admitted to Intensive Care Units from 2016-09-13T02:00

Health-Related Quality of Life: Increasingly Important in the Era of Effective, Modern Myeloma Therapy from 2016-09-06T20:00

Chemotherapy Induced Peripheral Neuropathy: A Novel Method of Exploration from 2016-08-14T19:56:41

This podcast highlights the innovative methodology employed in this study to determine risk factors for chemotherapy induced peripheral neuropathy, as well as implications of the findings to cli...

Changes in the Epidemiology of AIDS-Related Kaposi’s Sarcoma and Lymphomas: How This Informs the Clinician from 2016-08-08T20:00

This podcast will assist readers in understanding the clinical implications of the paper by Yanik and colleagues.  The paper describes the occurrence of Kaposi’s sarcoma and lymphoma in the era ...

Implicit Racial Bias Affects Key Aspects of Physician Communication from 2016-07-14T18:15:23

Implicit bias affects oncologists and their patients -  a few steps can help

Nivolumab Monotherapy is Safe and Active in Hematologic Malignancies from 2016-07-14T16:53:15

This podcast is a discussion of a clinical trial by Lesokhin et al which evaluated nivolumab monotherapy in patients with relapsed or refractory hematolo...

Minimizing Frailty in Cancer Survivors: A Meaningful Goal for All Ages from 2016-07-13T16:39:05

This podcast discusses the prevalence of and risk factors associated with a phenotype of accelerated aging among ALL survivors. Measurement and implications of frailty/pre-frailty are discussed....

1q Gain, a Prognostic Biomarker in Nephroblastoma, and What’s Next? from 2016-07-11T20:00

This podcast comments on two independent pediatric studies on both sides of the Atlantic showing the relevance of 1q gain in poor prognosis Wilms tumors which raises the perspectives for therape...

Therapy Impacts Long-Term Survival for Patients in Germany With Heritable Retinoblastoma from 2016-07-05T20:00

While ten-year overall survival has increased for German patients with heritable retinoblastoma, treatment modalities including radiation and/or chemotherapy can impact overall survival.

Dexamethasone and High-Dose Methotrexate in High-Risk B Cell Acute Lymphoblastic Leukemia—Where Should We Go From Here? from 2016-07-01T18:19:32

The Children's Oncology Group study led by Larsen et al. showed that children and young adult patients with high-risk B cell acute lymphoblastic leukemia benefit from receiving high-dose methotr...

Unraveling the Significance of Mismatch Repair Deficiency in Women With Endometrioid-type Endometrial Adenocarcinoma from 2016-06-20T20:00

This podcast discusses the study by McMeekin and colleagues regarding their analysis of the prognostic and predictive implications of mismatch repair deficiency status among a tissue sample regi...

Nodal Status After Neoadjuvant Chemotherapy Determines Prognosis in Localized Gastric Cancer from 2016-06-13T20:00

A central histopathological analysis of tumor material sampled within the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial shows that lymph node involvement is the...

Restrictions on Nutrition, Social Contacts, and Pets Are Not Effective Anti-Infective Measures in Children With Acute Myeloid Leukemia from 2016-06-06T20:00

Restrictions on nutrition, social contacts, and pets are not effective anti-infective measures in children with acute myeloid leukemia.

Current Status of Supplemental Screening in Dense Breasts from 2016-05-23T20:00

This podcast will review results from screening ultrasound and tomosynthesis in women with dense breasts and will discuss current and future use of MRI screening which may include average risk w...

Selective Internal Radiation Therapy for Liver-Dominant Metastatic Colorectal Cancer: Time to Put the Brakes On? from 2016-05-11T22:00

In this podcast, Dr. Andrew Ko discusses the SIRFLOX trial evaluating whether the addition of radioembolization to systemic chemotherapy confers any benefit in patients with liver-dominant metas...

Prognostication Based on Site of Metastatic Disease in Castration Refractory Prostate Cancer: Implications for Patient Care and Clinical Trial Design from 2016-05-03T14:48:52

Impact of site of metastasis on overall survival in castration
refractory prostate, and its implications on patient care and
clinical trial design.

IgM-Related AL Amyloidosis: A Rare Form of a Rare Disease from 2016-04-25T20:00

This podcast This JCO Podcast provides observations and
commentary on the JCO article, "A European collaborative study of
natural history, outcomes and validation of prognostic and respo...

Quality of Life: A Critical Consideration in Women Diagnosed with Ductal Carcinoma in Situ from 2016-04-12T19:49:09

This podcast puts into context the findings from Hart and colleagues, highlighting the clinical care and research implications.  

Very Late Outcomes of Wilms Tumor Survivors: British Childhood Cancer Study from 2016-03-29T14:09:48

Web-Based Technology Can Improve Patient Understanding and Preparedness to Discuss Cancer Clinical Trials: One Step Towards a Goal of Increased Enrollment from 2016-03-11T20:25:08

In this podcast, the article by Meropol et al. describing a randomized trial of a web-based educational tool versus a standard text-based resource is analyzed and placed in context of other chal...

How Should We Manage the Financial Toxicity of Cancer Treatment? from 2016-03-09T23:00

A study by Ramsey and colleagues suggests that extreme financial distress as manifested by personal bankruptcy might be associated with worse mortality in cancer patients. Long-term solutions ha...

Prognostication in Mantle Cell Lymphoma from 2016-02-29T21:00

The Ki-67 proliferation index improves the prognostic value of the MIPI score.

Sunbelt Melanoma Trial: A Seminal Adjuvant Interferon Trial with Long Term Results from 2016-02-08T21:00

Hepatocellular Carcinoma in Children and Adolescents: Time for a Strategy and a Trial from 2016-01-25T21:00

An update on clinical trials that have included children with hepatocellular carcinoma

Clinical Drug Development for Non-Muscle-Invasive Bladder Cancer…Definitions Matter from 2016-01-25T21:00

This podcast reviews the International Bladder Cancer Group’s recommendations regarding definitions and endpoints for the development of non-muscle-invasive bladder cancer clinical trials.

Race for the Cure: How differences in Race and Ethnicity Impact the Diagnosis and Survival of T-Cell Lymphoma from 2016-01-25T21:00

Ethnicity’s impact on diagnosis and survival of T-cell lymphoma

Epidural Spinal Cord Compression: The Importance of Multi-disciplinary Treatment Planning from 2016-01-12T23:00

Hard to RECIST: Updating and Simplifying Primary Tumor Response Guidelines for the Revised International Neuroblastoma Response Criteria (INRC) from 2016-01-11T21:00

This podcast reviews the accompanying article to provide the audience an understanding of the data and rationale to support updating the INRC primary site response criteria.

Expanding Immunotheapy Benefit in Metastatic RCC from 2016-01-11T21:00

Discussion of a phase I trial of the checkpoint inhibitor atezolizumab in metastatic renal carcinoma.

A New Oncogene Target in Lung Cancer: Exon 14 Alterations in the MET Gene from 2016-01-04T21:00

The Evolution of the Polycythemia Vera Symptom Burden: Implications for a Changing Treatment Paradigm from 2015-12-30T18:52:35

This podcast provides commentary on the importance of symptom assessment in Polycythemia Vera, and how this may impact therapeutic decision-making.

The Emerging Role of Gallium-68 Somatostatin-Receptor PET Imaging in Neuroendocrine Tumors from 2015-12-28T21:00

This podcast describes the evolving role of Gallium-68 somatostatin-receptor PET imaging in the evaluation of patients with well-differentiated neuroendocrine tumors, and compares the diagnostic...

Dexrazoxane for childhood cancer patients – ready for prime time? from 2015-12-23T15:33:29

Summarize the paper by Asselin et al and review the risks of therapy-related cardiomyopathy and evidence supporting dexrazoxane use in pediatric oncology.

Uterine lavage: a new approach to gynecologic cancer detection? from 2015-11-09T21:00

Recent findings represent an important and exciting step in applying the rapid advance of sequencing technologies to generate molecularly-driven approaches towards the detection of gynecologic m...

Hormonal Therapy is Out for Meningiomas: Time to Change Tactics? from 2015-11-02T21:00

The randomized placebo controlled trial of progesterone receptor blockade showed no difference in survival, finally answering the question about hormonal therapy in this disease and raising new ...

Defining the Optimal Interval for Colonoscopic Screening in Individuals with a Family History of Colorectal Cancer from 2015-11-02T21:00

This podcast discusses the study by Hennink and colleagues regarding their randomized controlled trial of a 3-year versus 6-year interval for screening colonoscopies in individuals with a family...

Using the CLIC Study of Outcome in Advanced Stages of Mycosis Fungoides and Sezary Syndrome to Guide Treatment And Clinical Research from 2015-10-05T18:20:56

This podcast reviews the current knowledge of staging and prognosis of mycosis fungoides and Sezary syndrome and evaluates the CLIC study, which aims to develop a prognostic index that can be us...

Geographic Access as a Barrier to Adjuvant Chemotherapy for Patients with Stage III Colon Cancer from 2015-08-24T20:00

This podcast summarizes new evidence about the role of travel distance, oncologist density, and insurance in receipt of guideline-based chemotherapy for patients with stage III colon cancer.

Host Factors and Lynch Syndrome Patients: Weighing Role of Obesity and Aspirin and Risk of Colorectal Cancer from 2015-08-17T21:15:12

This podcast will discuss the association of obesity and risk of developing colorectal cancer in Lynch syndrome patients based on a manuscript by Mohammad Movahedi and colleagues. In this manusc...

To Stop or Not to Stop: That is the Question from 2015-08-17T21:08:25

Breast Cancer and Weight Loss: Where Do We Go from Here? from 2015-08-17T20:00

The Promise and the Pitfalls of Population-Wide Screening of BRCA1 and BRCA2 from 2015-08-17T20:00

Intraperitoneal Therapy for Ovarian Cancer: No More Excuses from 2015-08-06T19:30

This podcast will examine data on utilization, toxicity and survival outcomes with the use of intraperitoneal chemotherapy for initial treatment of ovarian cancer at six NCCN institutions.

Balancing Safety and Efficacy in the Treatment Hodgkin Lymphoma: Early Discontinuation of Certain Drugs Can and Should Be Done from 2015-06-22T20:00

Analogous to prior analyses with ABVD, in a large series of Hodgkin lymphoma patients treated with BEACOPP, Haverkamp and colleagues from the German Hodgkin Study Group report that early discont...

When Toxicity and Efficacy Collide from 2015-06-08T20:00

This podcast explores the complicated relationship between potency, toxicity, and duration of therapy, and how each impacts the overall efficacy of therapy.

First Results of Euramos I and Logistics of International Collaboration for Clinical Trials of Rare Diseases from 2015-06-01T20:00

This study involved working together across oceans, regulatory bodies in various countries, different cultures in 4 cooperative groups, different standard chemotherapy administration guidelines,...

Treatment Advances in Local-Regionally Advanced and Stage IVB/Recurrent Cervical Cancer: Can We Agree that More Isn’t Always Better? from 2015-05-18T20:00

The two recent papers by Kitagawa, et al and Rose, et al, give us treatment options and tools that help maximize not only the benefits of survival with treatment but minimization of non-benefici...

Androgen Deprivation Therapy for Prostate Cancer - Friend or Foe to the Psyche? from 2015-05-11T20:00

This is a well-annotated study demonstrating that men treated with androgen deprivation therapy for prostate cancer have impaired cognitive performance within six months of starting therapy and ...

Building Blocks in the Case for Adjuvant Therapy in Biliary Tract Cancers from 2015-05-11T20:00

This podcast places the results of SWOG S0809, a phase II intergroup trial of adjuvant capecitabine/gemcitabine followed by radiotherapy and concurrent capecitabine in extrahepatic cholangiocarc...

Aromatase Inhibitor Arthralgias: Identification, Treatment Options and Research Perspectives from 2015-05-04T20:00

This is a requested commentary regarding a concurrently-published manuscript which evaluated the utility of omega-2 fatty acids for the treatment of aromatase inhibitor-associated arthralgias.

Deciphering the Heterogeneity Within EGFR-mutant Lung Cancer from 2015-04-20T20:00

A meta-analysis of 7 randomized trials comparing EGFR kinase inhibitors to chemotherapy for advanced EGFR-mutant lung cancer has shown that some populations gain greater benefit from targeted th...

Precision Immunology: The Promise of Tumor Immunotherapy for the Treatment of Cancer from 2015-04-15T15:02:54

This podcast discusses a novel immu...

The Importance of Discussing Genetics with Every Breast Cancer Patient from 2015-04-14T20:02:44

In summary, ...

Hematopoietic Stem Cell Transplant for Children With Acute Lymphoblastic Leukemia at BFM Centers: Comparable Results With Matched Sibling Donors and Matched Unrelated Donors from 2015-03-19T21:15:50

Review and c...

Is It Biology or Brawn in Ovarian Cancer Surgery? from 2015-02-09T21:00

This podcasts provides perspective on a recent report evaluating disease volume and surgical complexity on post-operative tumor residuum and survival in ovarian cancer patients.

Mirror Views: Reflections of Complementary Perspectives in Patient and Clinician Toxicity Reporting from 2015-02-05T18:57:16

In this podcast, Dr. Claire Snyder discusses how patient-reported outcomes provide a critical perspective to evaluating health conditions and their treatment, and describes several tools availab...

Dynamic Evolution of ALK Positive Non-Small Cell Lung Cancers and Management of Associated Brain Metastases from 2015-01-23T22:24:12

An analysis of the PROFILE studies and opportunities for treatment of ALK-rearranged non-small cell lung cancer

Prediction of Breast Cancer Risk After a Benign Breast Biopsy: A Practical Model? from 2015-01-21T20:53:04

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Prophylactic Anticoagulation in High-Risk Metastatic Germ Cell Tumor Patients: Who Should We Treat? from 2015-01-21T16:56:17

This JCO Podcast provides observations and commentary on the JCO article, "Large retroperitoneal lymphadenopathy as a predictor of venous thromboembolism in patients with disseminated germ cell ...

The Risk of Second Cancers for Patients with Endometrial and Rectal Cancer Receiving Radiation Therapy from 2014-12-22T21:00

This is an oral commentary on patients with endometrial or rectal cancer, and their risk of developing second malignancies with or without radiation.

Better Outcome of Chemo-Irradiation of Head and Neck Cancer in High-Patient-Volume Institutions from 2014-12-08T21:00

In a randomized RTOG study of chemotherapy concurrent with accel...

Is There a Future for Cyclooxygenase-2 Inhibition in Non-Small Cell Lung Cancer? from 2014-12-01T21:00

This podcast reviews the available data from clinical trials using cyclooxygenase-2 inhibition with chemotherapy in non-small cell lung cancer and provides a perspective on patient selection and...

The Treatment of Insomnia in Cancer Patients from 2014-12-01T21:00

This four-arm randomized controlled trial of cognitive behavioral therapy for insomnia in cancer patients confirmed its effectiveness but did not demonstrate benefit from the addition of a dayti...

The Biopsy Study: How the Use of Multiple Colposcopic-Directed Biopsies Improves Detection of Cervical Precancers from 2014-11-25T21:03:03

This podcast is a review of the submitted article by Dr. Wentzensen and colleagues regarding multiple cervical biopsies at the time of colposcopy and the implications for the management of cervi...

Intensified Frontline Chemoimmunotherapy with R-ACVBP May Improve Outcomes for Younger Patients with Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma from 2014-11-25T20:52:25

A secondary analysis of a multicenter randomized trial suggests that the R-ACVBP regimen may improve outcomes in younger patients with the non-germinal center B-cell subtype of diffuse large B-c...

A Positive Study of DTC-Guided Secondary Adjuvant Treatment in Early Breast Cancer: Ready for Prime Time? from 2014-11-25T20:51:46

Modifying therapy based upon positive DTCs in breast cancer.

A Second Course of Radiation Therapy for Painful Osseous Metastases Improves Patient Function and Quality of Life from 2014-11-25T20:50:53

NCIC SC.20 demonstrates that a second course of radiation for painful osseous metastases significantly improves patients quality of life and function.

Adjuvant Trastuzumab Passes the Test of Time from 2014-11-25T20:48:14

Long-term follow up from the landmark, NCI-sponsored adjuvant trastuzumab trials confirms the clinical benefits and clinical safety of this important therapy.

Prognostic Value of BRAF V600 E Mutation in Papillary Thyroid Cancer from 2014-11-25T20:47:35

This podcast provides a commentary on the association of braf mutation and thyroid cancer showing an increase risk of recurrence in patients with thyroid cancer that harbor this mutation.

Biochemotherapy: As Time Goes By? from 2014-11-25T20:46:53

In this podcast, the results of the S0008 adjuvant intergroup trial are discussed and placed in the context of current advances in melanoma treatment.

The First Prospective Trial of Proton Therapy for Children With Rhabdomyosarcoma: What We Learn From Preliminary Results from 2014-11-25T20:45:04

This is a prospective study of proton radiotherapy for rhabdomyosarcoma showing equivalent efficacy with photon treatment.

Intermediate Risk Pediatric Hodgkin Lymphoma: Early Response-Adapted Treatment Is Key from 2014-11-25T20:44:27

Tailoring treatment in intermediate-risk pediatric Hodgkin lymphoma is feasible using an early response-based assessment for the omission of radiotherapy.

Keeping Older Cancer Patients out of the Hospital: A Community Affair from 2014-11-25T20:42:18

Given the high rate of unplanned hospitalizations in older cancer patients, multidisciplinary care is needed for outcomes improvement.

Optimal Duration of MRD Monitoring During Therapy for Childhood ALL from 2014-11-25T20:41:22

Minimal residual disease monitoring has been very helpful in early response evaluation and risk stratification of children with acute lymphoblastic leukemia (ALL). This podcast discusses the pro...

Hepatitis B Reactivation in Patients Receiving Rituximab Can Be Detected Early and Managed with Antivirals from 2014-11-25T20:39:47

This podcast describes the report of a cohort of Chinese patients with known prior hepatitis B exposure, receiving rituximab as part of their therapy for lymphoma. The podcast includes a summary...

CT or No CT: An Important Question in Diffuse Large B-Cell Lymphoma from 2014-09-29T17:26:40

In this paper, the authors demonstrate that only a very small percentage of patients from 2 large, prospective cohorts developed recurrent diffuse large B-cell lymphoma detected solely on post remi...

Glembatumumab Vedotin (CDX-011, CR011-vcMMAE): On The Brink Of Targeted Therapy For Triple-Negative Breast Cancer? from 2014-09-29T17:25:56

A phase I/II study of the antibody-drug conjugate glembatumumab vedotin (CDX-011 or CR011-vcMMAE) in patients with locally advanced or metastatic breast cancer, reveals an acceptable safety profile...

Post-Transplant Cyclophosphamide for GVHD Prophylaxis: Back to the Future from 2014-09-29T17:24:43

Conventional GVHD prophylaxis with calcineurin inhibitors has a high incidence of chronic GVHD. Kanakri et al show that post-transplant administration of High dose cyclophosphamide is an effective ...

The Price Of A Drug is Not the Whole Cost from 2014-09-29T17:23:31

Many new oncology drugs are expensive. Drug prices may not reflect the whole cost of new agents, as increases or decreases in adverse effects compared to previously available therapies may influenc...

Cabozantinib in Advanced Prostate Cancer: Is the Therapeutic Window Too Narrow? from 2014-09-15T17:22:20

This podcast discusses a phase 2 trial of cabozantinib in men with advanced bone-metastatic prostate cancer, using a novel method to assess bone scan response.

Fracture Risk after Cystectomy: Don't Ignore It from 2014-09-02T18:51:44

This podcast discusses the results and practical implications of a population-based study that found an increased fracture risk after cystectomy for bladder cancer.

Is Hematopoietic Stem Cell Transplantation of Value in Treating Systemic Mastocytosis? from 2014-08-26T19:55:39

This podcast discusses the current state of knowledge regarding allogeneic transplantation as a treatment modality for advanced systemic mastocytosis.

Significant Dose Effect of Radiotherapy to the Pancreas and Risk of Diabetes Mellitus in Long-Term Hodgkin Lymphoma Survivors from 2014-08-26T19:53:11

This study assessed diabetes mellitus risk in long-term Hodgkin lymphoma survivors, and found that a mean pancreatic tail dose of 36 Gy or higher was associated with a significantly increased risk ...

The End of Rituximab Maintenance for Low Tumor Burden Follicular Lymphoma from 2014-08-26T19:52:11

This podcast reviews the publication of the RESORT manuscript, and puts these results into context with the recently published Ardeshna trial of rituximab vs. observation in follicular lymphoma, co...

Use of Mutational Analysis to Help Decide Whether Patients with Myelodsysplastic Syndromes Should Receive Allogeneic Hematopoietic Cell Transplant from 2014-08-26T19:51:15

This podcast will use the study reported by Bejar and colleagues to review the role of screening for TET2, DNMT3A, and particularly TP53, mutations in deciding whether to recommend allogeneic hemat...

Why are Fellows' Burnout Rates as High as Those of Practicing Oncologists? from 2014-07-21T21:10:42

This JCO Podcast provides observations and commentary on the JCO article, "Oncology Fellows' Career Plans, Expectations and Well-Being: Do Oncology Fellows Know What They are Getting In To?" by Tai...

Surprisingly Good Results in BCR-ABL1-like Pediatric Acute Lymphoblastic Leukemia: What Do They Mean? from 2014-07-21T21:09:12

This study reports surprisingly good outcomes for children with Ph-like ALL treated on the St. Jude Total Fifteen clinical trial.

Should Corticosteroids Be Used for the Treatment of Pain, Fatigue and Loss of Appetite in Cancer Patients Receiving Opioids? from 2014-07-07T21:28:29

Corticosteroids are recommended as part of the WHO analgesic ladder but there is limited evidence for their efficacy for the treatment of pain in cancer patients.

Breast Reconstructions: Inequities in Access Affecting Choice and Quality from 2014-07-03T21:30:07

The availability of reconstructive surgeons restricts the use of immediate breast reconstruction, creating unintended inequities even in a system with universal health care coverage.

Recurrent/Metastatic Human Papillomavirus-Associated Oropharynx Cancer: What Happens When This Good Prognostic Cancer Misbehaves? from 2014-06-23T15:06:10

This podcast describes the rising epidemic of HPV-associated oropharynx cancer, its unique demographic profile and natural history, and comments on new findings from Carole Fakhry et al. regarding ...

Long Term Cardiac Safety Data from the HERA Adjuvant Trastuzumab Trial from 2014-06-09T16:18:36

This podcast discusses the report of cardiac monitoring data from the HERA trial, places the findings in context with data from other trials, and considers how the report relates to clinical practice.

Breast Needle Core Biopsy: The Impact Surgeons and Geography Have on Utilization and the Impact on Patient Care from 2014-06-09T16:16:19

This is a review of breast needle biopsy for the diagnosis of breast cancer and how surgeons and geography affect utilization and the resultant impact on quality of care.

Identifying High-Risk Myeloma from 2014-06-02T14:46:05

FISH genetics, LDH and beta 2-microglobulin can identify a group of newly diagnosed myeloma patients with a two-year survival of only 52% in spite of bortezomib-based therapy.

Attempting to Avoid Chemotherapy in CLL with Lenalidomide and Rituximab from 2014-05-27T14:07:42

The current study, reporting on the upfront use of lenalidomide and rituximab in CLL, suggests high response rates and excellent tolerability in younger as well as older patients, albeit with a mod...

Breast Cancer Chemotherapy Effects on Brain Activation During Multitasking and Relation to Cognitive Complaints from 2014-05-27T14:05:42

This podcast summarizes the findings of a recent longitudinal functional MRI study examining the effects of breast cancer chemotherapy on multitasking-related brain activation and its relationship ...

Delayed Diagnostic Lumbar Puncture to Optimize Central-Nervous-System-Directed Therapy in Childhood Acute Lymphoblastic Leukemia from 2014-05-12T19:47:25

This podcast discusses the measures to optimize central-nervous-system-directed therapy in children with acute lymphoblastic leukemia.

Capecitabine Versus Continuous Infusion 5-FU for Rectal Cancer Neoadjuvant Chemoradiation: Equivalent Effectiveness Raises Real-World Questions About Efficacy, Adherence and Economic Implications from 2014-05-05T15:37:19

This trial supports the use of neoadjuvant capecitabine monotherapy as a potentially more convenient radiosensitizer that does not sacrifice surgical and pathologic outcomes in rectal cancer. Ho...

Evolving Treatment Paradigms for Primary Mediastinal Diffuse Large B-Cell Lymphoma from 2014-05-05T15:36:03

This podcast reviews the current role of PET and radiotherapy in PMBL.

Response Assessment in Hodgkin Lymphoma: Size Matters! from 2014-05-05T15:34:23

This podcast concerns the potential complimentary role played by PET and CT in the assessment of response in patients with Hodgkin lymphoma.

Second Tumors in PTEN Mutation-Positive Patients: Are They Recurrences or New Primaries? from 2014-04-28T16:51:05

Among more than 2,000 patients with an invasive cancer, more than 5% had a mutation in PTEN and almost half of these patients had a second malignancy. This observation has implications for patients...

Are Partners of Patients HPV-Positive Oropharyngeal Cancer at Increased Risk of Infection and Cancer? from 2014-04-28T16:49:51

This partner study suggests that spouses of people with HPV-positive oropharyngeal cancer do not have elevated oral HPV prevalence and the partners’ risk for oropharyngeal cancer remains low.

Planning to Survive: The Role of Physicians from 2014-04-21T21:32:23

This JCO podcast provides observations and commentary on the JCO article, "Provision and discussion of survivorship care plans with cancer survivors: Results of a nationally representative survey o...

Minimal Residual Disease (MRD) Study to Optimize Definition and Therapy of High-Risk Acute Lymphoblastic Leukemia from 2014-04-21T21:28:49

The study provides evidence that several patients with high-risk ALL who show a favorable MRD response to chemotherapy can achieve a cure without stem cell transplantation.

Risk-Reducing Oophorectomy in Women with BRCA1 and BRCA2 Mutations: An Opportunity to Personalize Recommendations for Cancer Prevention from 2014-03-31T21:26:33

This podcast summarizes and provides clinical conclusions of a large international study on ovarian cancer incidence and outcomes in women with BRCA1 and BRCA2 mutations.

Anti-EGFR Monoclonal Antibodies in the First-Line Treatment of RAS Wild-Type Metastatic Colorectal Cancer: The PEAK Experience from 2014-03-31T21:25:28

In this podcast, I will discuss first-line usage of anti-EGFR therapies in metastatic colorectal cancer in the context of the PEAK trial findings with a focus on the emerging data surrounding RAS o...

Accuracy of BRCAPRO in Women with Ovarian Cancer from 2014-03-17T19:37:31

This JCO podcast provides commentary on the accompanying JCO article "Underestimation of risk of a BRCA1 or BRCA2 mutation in women with high grade serious ovarian cancer by BRCAPRO: A multi-instit...

Serious Bevacizumab-Associated Gastrointestinal Toxicity from 2014-03-17T19:35:49

This podcast discusses the results of an analysis of the risk of severe gastrointestinal toxicity associated with the administration of bevacizumab to women with advanced ovarian cancer.

The Efficacy of Bevacizumab Combined with Chemotherapy for Platinum-Resistant Recurrent Ovarian Cancer Patients and Its Effects On Patient-Reported Outcomes from 2014-03-17T19:34:26

Observations from the AURELIA trial evaluating bevacizumab combined with chemotherapy in platinum resistant recurrent ovarian cancer patients and results from Patient-Reported Outcomes.

Nivolumab: Promising Survival Signal Coupled with Limited Toxicity Raises Expectations from 2014-03-03T20:42:19

This JCO podcast provides observations and commentary on the JCO article, Survival, Durable Tumor Remission, and Long-Term Safety in Patients with Advanced Melanoma Receiving Nivolumab,” by Suzanne...

Decision Shared or Otherwise-: The Ongoing Evolution of Local Therapy for Breast Cancer from 2014-02-18T20:39:54

Coincident with increased reconstruction with mastectomy are higher rates of mastectomy for early stage cancer and contralateral prophylaxis, suggesting the need for assessment of decision support ...

Is Early Initiation of Adjuvant Chemotherapy for Breast Cancer Better? from 2014-02-10T19:22:49

Early commencement of adjuvant chemotherapy is unlikely to be relevant for the majority of patients but unnecessary delay may be unwise for patients in whom the effect of adjuvant chemotherapy is e...

Single Agent Rituximab Active in Nodular Lymphocyte Predominant Hodgkin Lymphoma from 2014-02-10T19:21:27

This podcast describes the recent experience of single agent rituximab as management for newly diagnosed and relapsed nodular lymphocyte predominant Hodgkin lymphoma. The podcast includes a summary...

Adjuvant Treatment for Gastric Cancer: The Story Continues to Evolve from 2014-02-10T19:08:54

The mature results of a randomized comparison of S-1 versus observation
in Japanese patients who have undergone a D2 resection for gastric cancer continue to
show a significant survival ben...

Benefits of Modified Craniospinal Radiation Therapy for Children Treated for Medulloblastoma: Preserving Long-Term Neurocognitive Function from 2014-02-10T19:05:34

Children treated for medulloblastoma using reduced dose craniospinal radiation with local tumor bed boost have improved neurocognitive outcomes compared with conventional therapy, pointing to an op...

Breast MRI As It Is, In Contrast To How We Wish It To Be from 2014-01-06T16:40:28

The meta-analysis by Houssami and colleagues notes no recurrence benefit of breast MRI, and adds to a growing body of data demonstrating that the use of breast MRI in the non-high risk preoperative...

New Adoptive T Cell Therapy Has EBV-Positive Lymphomas on the Run from 2013-12-16T17:50:47

Reflections on a new report describing the successful therapy of lymphomas using adoptively transferred T cells targeting EBV latent membrane proteins.

Adjuvant High-Dose Interferon: New Evidence Regarding Treatment Duration and Survival Impact in Melanoma from 2013-12-16T17:49:05

This podcast provides observations and commentary on the study by Payne and colleagues entitled ‘Phase II Pilot Study of Intravenous High Dose Interferon with or without Maintenance Treatment in Me...

Some like It Even Hotter: Escalating Radioimmunotherapy in Follicular Lymphoma? from 2013-12-02T19:08:47

An increased-dosage radioimmunotherapy for upfront treatment of follicular lymphoma achieves excellent results, raising questions on the best choice of treatment in this disease.

Increasing Cytarabine Dose in AML Induction Improves Outcomes in Younger Patients from 2013-12-02T19:07:12

This podcast describes the recent experience of high dose cytarabine induction in patients with acute myeloid leukemia (AML), as reported in the EORTCGIMEMA AML-12 trial. The podcast includes a sum...

The Value of Preoperative MRI in Predicting Outcome in Patients with Rectal Cancer from 2013-11-25T17:35:59

MRI done prior to surgery can be useful in determining the long-term outcomes after surgical resection in patients with rectal cancer.

Refining Stringency of Response in Myeloma from 2013-11-18T19:12:17

The study by Kapoor et al supports reporting outcome of clinical trials using more stringent uniform response criteria.

When Hodgkin Lymphoma Relapses in The Older Patients from 2013-11-04T16:54:19

This podcast reviews outcomes for elderly patients with HODGKIN lymphoma at diagnosis and at the time of relapse.

How Do We Decide Who Should Be Offered a Sentinel Node Biopsy When Their Melanoma Is Less than 1mm in Thickness? from 2013-11-04T16:52:32

Sentinel node biopsy should be performed for melanomas greater than or equal to 0.75mm in thickness but not for melanomas less than 0.75mm in thickness.

FISH for Smoldering Multiple Myeloma from 2013-11-04T16:50:39

This podcast discusses Neben and colleagues' paper on FISH findings and smoldering myeloma.

External Beam Accelerated Partial Breast Irradiation: Exploring the Limits of Tolerability from 2013-10-09T19:01:28

This JCO Podcast comments on the JCO article, "Interim Cosmetic and Toxicity Results From Rapid: A Randomized Trial Of Accelerated Partial Breast Irradiation Using 3D Conformal External Beam Radiat...

Minimal Residual Disease (MRD) in Acute Myeloid Leukemia- Are we Ready for Individualized Risk Assessment Based on MRD? from 2013-09-23T19:50:57

Before we can use MRD as a guide of post-remission therapy in AML, we have to standardize our methods for MRD quantification and agree on the definition of MRD-positive versus MRD-negative patients.

Functional Imaging as a Biomarker for Survival in Locoregionally Advanced Non-Small Cell Lung Cancer Patients from 2013-09-16T20:00

ACRIN 6668/RTOG 0235 demonstrates that a post chemoradiotherapy PET scan for locoregionally advanced non-small cell lung cancer can be used as an early indicator for long-term outcome.

EORTC 18961 GMK Vaccine Adjuvant Trial: Unfulfilled Promise for Another Vaccine Trial from 2013-09-09T19:07:14

Added to the complexity of the widening variety of vaccines that are in current clinical trial for human cancers, and the increasing sophistication of our tools for assessment of the immune respons...

Lenalidomide Monotherapy for Relapsed Mantle Cell Lymphoma from 2013-09-03T14:36:53

Lenalidomide is a promising agent for the treatment of mantle cell lymphoma.

Flying Solo: Chemotherapy Without Radiation for Primary Central Nervous System Lymphoma from 2013-08-26T15:54:16

The results of CALGB 50202 reported by Rubenstein and colleagues demonstrate the feasibility, safety and efficacy of the MT-R induction and EA consolidation regimens in newly diagnosed PCNSL patients.

Second Hematopoietic Transplants for Relapsed AML from 2013-08-05T16:23:08

This podcast reviews the biology and treatment of relapse of acute myeloid leukemia following hematopoietic transplantation.

In End-Of-Life Decision-Making, Does DNR Measure Up? from 2013-07-29T20:48:53

The ability of an advance care planning discussion to affect end-of-life decisions is tested in a randomized, controlled trial of patients with advanced cancer.

A Clear Answer to the Wrong Question from 2013-07-12T20:01:02

The AVAPERL trial reveals a significant improvement in progression-free survival with the combination of pemetrexed/bevacizumab compared with bevacizumab alone as maintenance therapy for advanced n...

Bisphosphonate-Related Osteonecrosis of Jaw (BOJN) in the Adjuvant Breast Cancer Setting: Risks and Perspective from 2013-06-24T16:03:55

This JCO Podcast provides observations and commentary on the JCO article “Osteonecrosis of the Jaw and Oral Health-Related Quality of Life After Adjuvant Zoledronic Acid: An Adjuvant Zoledronic Aci...

Should Myeloma Residual Disease Become a Standard Assay for Large Cooperative Groups and Myeloma Referral Centers? from 2013-06-03T21:05:18

Minimal residual disease predicts outcomes in myeloma.

The Prognosis of Breast Cancer Diagnosed During Pregnancy from 2013-06-03T21:02:56

This podcast provides an overview and commentary on Amant et al.'s study of breast cancer diagnosed during pregnancy.

The SUCCEED Trial: Maintenance Ridaforolimus for Metastatic Soft- Tissue Sarcomas from 2013-05-30T02:59:14

This podcast provides observations and commentary on the JCO article,"Results of an international randomized phase 3 trial of the mTOR inhibitor, ridaforolimus, versus placebo to control metastatic...

Who Needs What Therapy? The Elusive Search for Predictive Markers from 2013-05-06T16:41:18

Loss of PTEN expression did not predict resistance to trastuzumab in early stage HER2 positive breast cancer in the large US cooperative group phase III trial N9831.

Micro RNAs and Other Molecular Markers in AML Therapeutics from 2013-05-06T16:40:25

This podcast describes the current and future use of molecular testing, including micro RNA expression, in the management of AML.

Neuroanatomic and Neuropsychological Outcomes in Adults after Treatment for Childhood Acute Lymphoblastic Leukemia from 2013-04-15T18:52:59

This podcast focuses on emerging concerns about adult outcomes in survivors of acute lymphoblastic leukemia treated in childhood and adolescence in the context of the report by Zeller and colleague...

HERA Indicates that Adjuvant Trastuzumab Confers Equal Benefit for HER2-Positive Invasive Ductal and Invasive Lobular Breast Cancers from 2013-04-15T18:42:22

This Podcast reviews the results of the analysis conducted by Metzger-Filho et al. regarding the benefit of trastuzumab for patients with invasive lobular breast cancer treated on the Herceptin Adj...

New Evidence of the Clinical Significance of Cigarette Smoking by Colon Cancer Patients from 2013-04-01T20:41:34

This podcast summarizes findings regarding cigarette smoking and disease-free survival in a Phase III adjuvant colon cancer trial.

Rituximab Maintenance is Safe After Autologous Stem Cell Transplantation from 2013-04-01T20:34:07

The paper reviewed comes to the conclusion that rituximab maintenance prolongs PFS in patients transplanted for follicular lymphoma , without causing relevant toxicity.

Radiotherapy for Pediatric Hodgkin Lymphoma: Are We Ready To Say Goodbye? from 2013-03-18T17:59:46

Response after early chemotherapy cycles might identify patients who could safely forgo consolidation with radiotherapy.

Minimal-Intensity Conditioning: A Decade Later from 2013-03-11T16:06:42

This podcast reflects on the outcome of minimal intensity conditioning in over 1000 recipients of sibling and unrelated donor transplant.

Evolution of Concurrent Chemoradiation Treatment Approaches in Head and Neck Cancer from 2013-03-05T22:11:15

This podcast provides commentary and observations on the long term results summary of RTOG 91-11 in which concurrent chemoradiation was shown to provide superior outcome over induction chemotherapy...

Off-Label Cancer Therapy Use: How Much is Too Much? from 2013-02-19T19:57:40

This podcast reviews findings on the prevalence of off-label cancer therapy use and the estimated costs associated with it.

Caring For Patients With Transformed Follicular Lymphoma from 2013-02-12T20:37:22

If transplantation is selected as the treatment approach, the net effect is likely to be similar with allogeneic or autologous transplantation with the higher early mortality rate in the allogeneic...

Outpatient Therapy for Fever and Neutropenia is Safe But Implementation is the Key from 2013-01-28T21:14:12

The fluoroquinolone class of antibiotics is a major target for antimicrobial stewardship programs, and the conservation of their effectiveness is important.

Outcomes in Cancer Survivors Who Develop Second Malignant Neoplasms from 2013-01-22T22:32:34

This podcast provides perspective on findings in a large population-based evaluation of overall survival and cancer-specific survival in patients with CLL who develop a second primary cancer.

Molecular Profiling of Gastric Cancer: Toward Personalized Cancer Medicine from 2013-01-22T22:31:14

One third of gastric cancers harbor genetic or epigenetic alterations in the CDH1 gene, and those with structural changes have a poorer prognosis; gastric tumor profiling for oncogenic amplificatio...

Reflections on "Cancer Survivorship": Evolution, Utility, and Acceptability from 2013-01-03T20:24:03

This podcast considers the evolution, utility, and acceptability of the terms 'cancer survivor' and 'cancer survivorship' and comments on a recent article in JCO that addresses the extent to which ...

Estimating the Risk for Contralateral Breast Cancer as a Guide for Surgical Treatment from 2013-01-03T20:21:59

This podcast discusses approaches to risk assessment of contralateral breast cancer and factors which predict the risk.

Revisiting Combination TACE-RFA Treatment for HCC from 2013-01-03T20:19:19

Amongst several different liver directed therapy approaches, chemoembolization (called TACE) and radiofrequency ablation (called RFA) are most commonly used worldwide. However, the efficacy of TACE...

Novel Insights From a Phase II MEK Inhibitor Trial in BRAF Mutant Melanoma from 2012-12-19T19:53:36

A discussion of a phase 2 trial of a MEK inhibitor in patients with V600 BRAF mutations and consideration of other relevant results with targeted therapies in this population.

Successful Non-Intensive Bridging of MDS Patients Towards Allografting from 2012-12-19T19:51:35

This podcast discusses therapeutic options for MDS patients including azacytidine and allogeneic stem cell transplantation.

Using a Video Decision Support Tool for CPR Decision-Making from 2012-12-11T15:27:58

This video support tool describing CPR lets patients make much better informed decisions about the use of CPR. Physicians often feel that CPR will not be of help to patients but nevertheless feel o...

Radioimmunotherapy for the Initial Treatment of Follicular Lymphoma from 2012-12-11T15:24:33

Radioimmunotherapy alone or in sequential combination with chemotherapy is effective initial treatment for follicular lymphoma, though comparable (and not superior) to other management options for ...

Management of Metastases to the Brain: A Therapeutic Conundrum from 2012-12-03T21:03:29

Whole-brain radiation therapy of metastases to the brain is not innocuous - it is associated with decrements in health-related quality of life. It is still unknown if the potential benefits outweig...

Understanding the Role of MET Kinase in Cancer Therapy from 2012-12-03T21:02:17

This is a commentary on the role of MET in cancer using Choueri et al as an example of rationale therapeutics and translational research.

AIDS Related Lymphomas - More Options and More Questions from 2012-11-19T20:19:38

A discussion of treatment approaches for newly diagnosed aggressive AIDS-related lymphomas

Long Term Follow-up of NSABP B-31: How Well Can We Predict Cardiac Toxicity with Trastuzumab? from 2012-11-16T19:26:44

Seven year follow up of B-31 demonstrates a striking and reassuring lack of longer-term cardiac events.

More Adjuvant Chemotherapy is Not Always Better from 2012-11-16T19:23:54

More adjuvant chemotherapy is not always better for early breast cancer patients - Discussion and consequence for clinical practice.

Hodgkin Lymphoma: Protecting the Victims of Our Success from 2012-11-13T17:00:13

The podcast reviews the evolution of staging and treatment of Hodgkin lymphoma, reducing the toxicities and torture while maintaining a high level of cure.

Beyond the Plasma Cell: Proteasome Inhibition in Acute Myelogenous Leukemia from 2012-11-02T15:02:57

In this podcast, Attar and colleagues explore whether patients aged 60-75 who enter remission with bortezomib added to standard anthracycline plus cytarabine chemotherapy during induction can be s...

Breast Brachytherapy in the United States: Increasing Use Despite Increased Complication Rates from 2012-11-01T20:23:36

This podcast will review a JCO article showing that the use of breast brachytherapy as a method of delivering partial breast radiation after breast conserving surgery was associated with higher rat...

Referral Practices to Palliative Care Among Canadian Oncologists from 2012-11-01T20:21:30

This Podcast provides observations and commentary about referral practices of oncologists to specialized palliative care.

Clinical Utility of Screening Tests in Asymptomatic Long-Term Childhood Cancer Survivors from 2012-11-01T19:30:44

This podcast characterizes the clinical utility of the screening tests recommended by the Children’s Oncology Group in the care of long-term survivors.

Is Lymphatic Mapping Ready for Clinical Use in the Treatment of Squamous Vulvar Cancer? from 2012-10-30T22:18:31

Publication of a large collaborative group trial appears to definitively demonstrate the safety of sentinel lymph node biopsy as replacement for inguinal-femoral lymphadenectomy, or does it?

Rituximab Maintenance Therapy After Autologous Stem Cell Transplantation: Final Analysis of the CORAL Trial from 2012-10-23T09:53:05

In this podcast, results of a randomized phase III clinical trial evaluating the use of Rituximab maintenance therapy following autologous stem cell transplantation in patients with relapsed diffus...

Informed Consent for Pediatric Phase I Cancer Trials: An End-of-Life Decision from 2012-10-15T20:18:16

Melissa Cousino and colleagues found that few parents understand the scientific purpose of phase I pediatric clinical trials.

Outcome in Systemic Anaplastic Large Cell Lymphoma: Beyond ALK from 2012-10-08T20:35:15

The prognostic importance of ALK-protein expression was established over a decade ago. More recent studies emphasize that age is also an important driving force and in patients <40 years, the dist...

Should Gemtuzumab Ozogamicin Be Re-added to the Therapeutic Armamentarium for Acute Myeloid Leukemia? from 2012-09-17T14:33:31

Although gemtuzumab ozogamicin has been withdrawn from the marketplace, three randomized trials prompt review of that decision.

Immunohistochemical Double Hit Score in Diffuse Large B-Cell Lymphoma: The Potential to Screen All Tumors for High-Risk Biology from 2012-09-04T19:33:26

This podcast summarizes and places in clinical context two studies describing straightforward immunohistochemical methods to risk-stratify diffuse large B-cell lymphoma.

In a Sea of Data the Water is Still Murky: Meta-Analysis of Cognition in Breast Cancer from 2012-08-27T15:32:39

Cognitive impairment occurs in a subset of breast cancer survivors after chemotherapy but the incidence remains unknown.

KRAS G13D Mutations in Metastatic Colorectal Cancer: Are They Different From Codon 12? from 2012-08-24T18:00:58

This podcast discusses the manuscript by Tejpar et al in which patients whose colorectal tumors harbor a specific KRAS mutation, G13D, appear to have benefit in two clinical trials with regard to t...

Taxane Induced Peripheral Neuropathy: A Continued Challenge but Not a Biomarker of Treatment Efficacy from 2012-08-10T16:29:07

Although historically toxicity was often thought to be a biomarker of efficacy, often it appears to be a marker of dose intensity and individual susceptibility as is the case in this retrospective ...

Is This Nomogram Ready To Roll? from 2012-06-25T18:29:17

In this podcast, Dr. Hudis reviews the use of a novel nomogram to predict the benefits of postoperative adjuvant radiation therapy for older women with early stage breast cancer. This discussion h...

Adjuvant Chemotherapy in Older Patients with Stage III Colon Cancer from 2012-06-04T20:25:34

As oncologists treat an increasing number of older patients with colon cancer, and as treatment options improve for older patients, oncologists should work with geriatricians to make the best treat...

The Combination of Bortezomib, Thalidomide, and Dexamethasone in Relapsed Multiple Myeloma from 2012-05-14T19:43:51

This podcast will provide a critical evaluation of the combination of bortezomib, thalidomide, and dexamethasone in relapsed multiple myeloma

Personalized Therapy for Breast Cancer: Is It Really Happening? from 2012-05-09T19:30:22

This Podcast reviews and comments on the use of the National Comprehensive Cancer Network (NCCN) Breast Cancer Outcome Database to demonstrate the actual rollout of the use of gene expression profi...

Routine Second Pathology Review for Node-Negative Breast Cancer: What is Learned and What is the Effect on Patient Care? from 2012-05-07T20:18:01

This Podcast reviews the design and results of the present study by Kennecke et al. and provides perspective regarding the clinical significance of these findings.

Pre-Operative Metformin in Early-Stage Breast Cancer from 2012-05-07T20:14:51

This podcast reviews the rationale behind evaluation of metformin as a potential anti-cancer agent in breast cancer and describes the findings of a recent window of opportunity trial looking at the...

Fulvestrant and Anastrozole in Combination: FACT or Fiction? from 2012-04-30T20:07:34

This podcast reviews the results of the FACT trial in the context of other ongoing and proposed studies of endocrine therapy combinations.

A New Day Dawning for Hodgkin Lymphoma? from 2012-04-30T20:07:33

This podcast describes a phase 2 trial brentuximab vedotin in patients with Hodgkin lymphoma that has recurred after autologous hematopoietic stem cell transplantation. The podcast discusses the ra...

The German CAO/ARO/AIO-94 Randomized Phase III Trial After a Median Follow Up of 11 Years: Implications of Long Term Follow Up from 2012-04-23T19:45:17

In this study, the implications of long term follow up of the German Rectal Study on clinical practice and future trial design will be discussed.

Carboplatin-Gemcitabine-Bevacizumab: Expanding Treatment Options for Recurrent Platinum Sensitive Epithelial Ovarian Cancer from 2012-04-23T19:45:16

Carboplatin-Gemcitabine-Bevacizumab represents an additional regimen to consider for management of recurrent platinum sensitive epithelial ovarian cancer, although it raises several questions regar...

The Use of Adjuvant Therapy in Elderly Patients with Resected Non-Small Cell Lung Cancer (NSCLC) from 2012-04-23T19:45:15

This podcast discusses adjuvant therapy in elderly NSCLC patients.

Management and Prevention of Pain Related to Treatment or Disease from 2012-04-16T19:16:17

The podcast highlights recent JCO articles that underscore the need for improved assessment and management of cancer and treatment-related symptoms.

1 + 1 = 3. Combined Use of Anti-HER2 Agents in the Neoadjuvant Setting from 2012-04-09T19:07:04

The CHER-LOB trial is one of several that has demonstrated that adding lapatinib to trastuzumab and chemotherapy improves on the rates of complete pathological response among women receiving neoadj...

Management of Low Stage Ovarian Clear Cell Carcinoma from 2012-04-09T19:07:03

A reflection on the problems clinicians face when making a decision on how best to advise patients regarding management of early clear cell carcinoma of the ovary.

Surviving Childhood Cancer: Defining Risk of Poor Cardiac Outcomes in Early and Middle Adulthood from 2012-04-02T18:11:13

This podcast provides observations and commentary on the JCO article "High risk of symptomatic cardiac events in childhood cancer survivors.

No Advantage to Combining Cetuximab with 5FU, Leucovorin, and Oxaliplatin in Metastatic Colorectal Cancer from 2012-04-02T18:11:12

This podcast reviews a negative phase III clinical trial of cetuximab combined with chemotherapy in first-line metastatic colorectal cancer and focuses on the interaction of targeted therapy combin...

Sorting Through Early Melanomas to Identify Those at Higher Risk for Metastases from 2012-03-12T18:42:16

This podcast partitions patients with early melanoma into those with very favorable features and compares them to those with a higher risk for dying of metastatic melanoma.

Sedation for the Management of Refractory Suffering from 2012-03-12T18:40:05

Incorporating the information form Dr Marconi's systematic review on the question "Does sedation at the end of life hasten death", I will provide useful guidance regarding how to discuss this issu...

The Role of the Estrogen Receptor (ER) in Selecting Women, Diagnosed with DCIS for Adjuvant Therapy with Tamoxifen from 2012-03-05T21:44:45

This podcast describes the results from a subgroup of 732 women in the NSABP B-24 trial for the treatment of DCIS, where ER status was available, and describes how this can be used as a predictive ...

How Cooperative Group Trials Impact Breast Cancer Care in United States from 2012-03-05T21:40:37

In this podcast, I will review a JCO article showing that the publication of CALGB C9343 trial results had little influence in practice patterns in the United States. I will discuss possible study...

What's Different Between One Colorectal Cancer and Another? It's All in the Genes from 2012-03-05T21:37:25

This podcast will discuss the current role of characterizing KRAS and BRAF in the management of colorectal cancer as well as a manuscript by Popovici and colleagues entitled "Identification of a po...

Molecular Tumor Analyses Followed by First Line Oral Tyrosine Kinase Inhibitors in Lung Adenocarcinomas with Driver Abnormalities from 2012-02-28T19:12:04

Patients with epidermal growth factor receptor (EGFR) gene mutations should receive EGFR tyrosine kinase inhibitors as 1st line therapy because they produce higher response rates, long progression ...

Placing the P Value into Perspective: Does Paclitaxel Add Value to Gemcitabine and Cisplatin in Advanced Urothelial Cancers? from 2012-02-28T19:09:41

This JCO Podcast provides observations and commentary on the JCO article, "Randomized Phase III study comparing Paclitaxel Cisplatin Gemcitabine and Gemcitabine Cisplatin in patients with locally ...

Early Stage Hodgkin Lymphoma -- How Much is Enough? from 2012-02-21T20:26:38

The management of patients with early stage Hodgkin lymphoma with unfavorable characteristics remains a topic for study.

The Rich Get Richer: Another Efficacious Option for Refractory Hairy Cell Leukemia from 2012-02-21T20:24:06

This podcast reports on a phase I/II trial investigating novel anti-CD22, moxetumomab pasudotox, in the treatment of patients with refractory hairy cell leukemia, which demonstrated responses in th...

Rethinking Our Use of CSFs in the Adjuvant Treatment of Women Who Have Estrogen Receptor Positive Cancers from 2012-02-06T20:22:31

When dose dense treatment was first described we were greatly enthusiastic for all women with breast cancer. As the experience has matured we now realize that the benefit is confined to women with ...

Recurrence and Survival Results of the GOG Lap2 Trial Confirm Safety of the Laparoscopic Approach to Surgical Staging and Treatment for Uterine Cancer from 2012-01-30T18:26:07

This podcast summarizes and discusses the outcome results of the GOG Lap2 trial which shows safety and clinical benefits of laparoscopy as compared to laparotomy for surgical staging and treatment ...

"Anything You Can’t Do, I Can’t Do Either": Transplantation for High Risk AML from 2012-01-30T18:23:15

This is a commentary on a report from the EBMT demonstrating a higher relapse rate after allogeneic transplantation in AML patients with FLT3 ITD mutations.

Safety and Efficacy of Sequential Adjuvant AI Therapy in ER Positive Breast Cancer from 2012-01-19T18:36:50

Long-term follow-up of efficacy and toxicity outcomes from the IES study of adjuvant aromatase inhibitor therapy in postmenopausal estrogen receptor positive breast cancer

The Role of Ovarian Suppression for Fertility Preservation in Women Receiving Adjuvant Breast Cancer Chemotherapy from 2012-01-09T21:00:42

This podcast discusses the findings from the manuscript by Munster et al. regarding the use of ovarian suppression for fertility preservation in young women receiving adjuvant chemotherapy in the c...

Using BCR-ABL Transcript Levels After 3 Months of Therapy on Imatinib is the Best Way to Predict Long-Term Outcome for Patients with CML Treated with Imatinib from 2012-01-09T15:12:25

The study by Marin et al is another milestone in our understanding how to manage CML patients on tyrosine kinase inhibitors.

The Importance of Tumor Biopsies for Analysis of Mechanisms of Response and Resistance in Prostate Cancer from 2011-12-19T20:45:29

This podcast will summarize the results of Efstathious et al and discuss possible mechanisms of resistance to castration based therapies in prostate cancer.

Targeting the Angiopoietin-Tie2 Axis: A Promising Alternative Antiangiogenic Strategy for Epithelial Ovarian Cancer from 2011-12-19T20:45:28

Targeting the Angiopoietin-Tie2 axis is a promising alternative antiangiogenic strategy for the treatment of ovarian cancer that exhibits non-overlapping toxicities with inhibitors of the VEGF sign...

Interim PET Scans in Diffuse Large B-Cell Lymphoma - More Than Another Biomarker? from 2011-12-12T20:59:31

This podcast reviews data from a recent publication on the use of "early" interim PET scanning in diffuse large B-cell lymphoma and comments on the clinical utility of this imaging technique in th...

To Biopsy or Not to Biopsy? That is the Question from 2011-12-07T19:18:21

Biopsy of presumed metastatic breast cancer sites confirms the diagnosis in most women
and alters therapy in 14% of women in a prospective study of 121 patients but its impact
on outcome co...

Disparities in Systemic Therapy for Breast Cancer from 2011-12-05T15:42:57

This podcast provides a commentary on the article by Wu et al that addresses disparities in systemic therapy for breast cancer.

Adjusting for Treatment Cross-Over to Enable Analysis of Longer Term Outcomes in the MA.17 Trial from 2011-11-28T21:38:41

This Podcast reviews the background of the MA.17 trial, the results of the
present manuscript and provides perspective on the current findings.

Obesity and Colorectal Cancer: What's the Big Deal? from 2011-11-28T21:38:40

This podcast summarizes the findings of this JCO article and provides commentary
on its applicability to practice.

Combinations or Single Agents, Crossover or No Crossover: Considering Chemotherapy Strategies in the Multi-Chaptered Story of Metastatic Breast Cancer from 2011-11-14T17:22:46

This podcast will critically review randomized phase III trial data examining the relative role of taxane
monotherapy versus combination therapy as first-line treatment for HER2-negative metast...

Medical Oncologist Attitudes and Practice in Cancer Pain Management: A National Survey from 2011-11-14T17:22:45

This podcast discusses findings and implications of a recent survey study on attitudes and
knowledge about cancer pain among medical oncologists

Is a "Wait and See" Nonoperative Approach Justified after Chemoradiation for Rectal Cancer from 2011-11-07T19:23:57

This podcast will explore the feasibility of a nonoperative "wait and see" approach based on strict selection criteria in patients with locally
advanced rectal cancer who achieve a complete cli...

Predictive Testing for BRCA1/2 Mutations: The Value of the "True"Negative from 2011-10-31T18:27:07

This podcast reviews the evidence that women testing negative for known familial BRCA1/2 mutations should adhere to current population breast cancer screening guidelines.

Trastuzumab in the Adjuvant Setting - Sequential versus Concurrent: Will We Ever Know the Full Answer? from 2011-10-31T18:06:35

This Podcast provides observation and commentary on the JCO article "Sequential versus
concurrent trastuzumab in adjuvant chemotherapy for breast cancer".

Solving the Mystery of Recurrence in "Surgical Cures" for Early Non-Small Cell Lung Cancer from 2011-10-11T18:55:42

Podcast to review the article "Occult Metastases in Length Nodes Predict Survival In Resectable Non-Small Cell Lung
Cancer: Report of the ACOSOG Z40040 Trial" by Rusch et al.

Comorbidity Data in Cooperative Trials: Feasible and Non Ignorable from 2011-10-11T18:55:41

The ATAC investigators collected comorbidity data on more than 9000
women and this article illustrates that it provides key information.

Gender Equity and HPV-Associated Cancers in the United States from 2011-09-29T20:06:19

Rapid, dramatic shifts are ongoing in the population-level epidemiology of
oropharynx cancer in the United States.

Biomarker Selection for Maintenance Therapy in Advanced NSCLC from 2011-09-29T20:06:18

EGFR mutation is a predictive biomarker for maintenance erlotinib but its clinical application is limited. This podcast will explain why.

Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia from 2011-09-26T14:15:30

This podcast summarizes the incidence and long-term outcome of osteonecrosis in a large
prospective study of children treated for acute lymphhoblastic leukemia with the
dexamethasone-based ...

R-CHOP Chemotherapy as Upfront Treatment for Advanced Stage Follicular Non-Hodgkin Lymphoma from 2011-09-15T20:46

This podcast evaluates the context and reviews results of a randomized phase III trial comparing R-CHOP given at conventional 21 day intervals with R-CHOP given at 14 day intervals in patients with...

Venlafaxine and Clonidine for Treatment of Hot Flashes in Women with Breast Cancer from 2011-09-12T18:53:10

This podcast reviews the randomized double-blind placebo-controlled trial reported by Boekhout
et al. that evaluates venlafaxine and clonidine for the treatment of hot flashes in women with
Listen

Response to Neoadjuvant Systemic Therapy for Breast Cancer in BRCA Mutation Carriers and Non-Carriers: A Single Institution Experience from 2011-08-31T18:30:19

This podcast reviews the retrospective study by Arun et al. and discusses the lack of consensus regarding the relative chemosensitivity of breast cancers in mutation carriers
and non-carriers a...

Individualizing the Risk of Cardiovascular Mortality Following Androgen Deprivation Therapy for Prostate Cancer from 2011-08-15T20:04:25

Androgen deprivation therapy may not be associated with an increase in cardiovascular mortality in all men but only those with a prior cardiac event due to known coronary artery disease.

High Risk Stage II Colon Cancer: What is the Role of Adjuvant Chemotherapy? from 2011-07-21T17:15:51

Stage II colon cancer with high risk factors is often treated with adjuvant therapy, however new data raise questions about the usefulness of this practice.

Is Genotype Guided Tamoxifen Dosing Ready for Prime Time? from 2011-07-18T17:11:56

Commentary on a successful study in which genotype-guided tamoxifen dosing increased endoxifen concentrations in women with reduced CYP2D6 metabolism.

Menopausal Hormone Therapy, Mammographic Density and Breast Cancer from 2011-06-23T19:35:55

Estrogen plus progestin and estrogen alone have different effects on mammographic density and breast cancer.

The Growing Value of Risk Calculators for Men Considering Prostate Cancer Screening from 2011-06-20T14:16:41

This is a commentary on a recent study comparing two risk calculators for use in the setting of prostate cancer screening.

Interpretation of the Biomarker Analysis and Final Overall Survival Results from IPASS from 2011-06-13T14:23:01

This podcast describes the analysis of the IPASS study population by EGFR mutation and EGFR FISH biomarker status, and also discusses the results and controversial analysis of overall survival from...

Curing Leukemia with a Single Drug from 2011-06-06T14:42

The use of arsenic trioxide as a single agent can produce long lasting remissions and a significant cure rate in patients with acute promyelocytic leukemia.

Vaccination with an Autologous Idiotype Based Vaccine Following a Chemotherapy Induced Remission Holds Promise in the Treatment of Patients with Follicular Lymphoma from 2011-05-31T13:48:07

In this podcast, results of randomized phase III clinical trial evaluating the effects of a patient specific idiotype tumor vaccine in patients with follicular lymphoma are summarized. The results...

Pathologic Complete Response and Toxicity Results from the STAR-01 Trial Evaluating the Addition of Oxaliplatin to Neodjuvant Chemoradiation for Locally Advanced Rectal Cancer from 2011-05-23T15:17:30

The addition of oxaliplatin to fluorouracil-based neoadjvuant chemoradiation for locally advanced rectal cancer significantly increases toxicity but does not improve the pathologic complete respons...

MEK Inhibitors from 2011-05-16T14:35:36

The term targeted therapy is often used in cancer drug development. This podcast will discuss the study of a mEK inhibitor where the investigators actually looked at the impact on the target as we...

Angiogenic Therapy in Breast Cancer: Axitinib with Chemotherapy Joins the Crowd from 2011-05-09T14:38:16

Commentary on a new small molecule inhibitor of angiogenesis in combination with chemotherapy for metastatic breast cancer.

Advanced Radiation Therapy Technology Improves Survival in Lung Cancer from 2011-05-02T18:57:51

This SEER based study demonstrated that the advanced radiation therapy technique of three-dimensional conformal radiation therapy improved survival compared to the previously used method.

The Dark Side of del(5q) MDS from 2011-04-25T20:36:32

This podcast will discuss the basic background of myelodysplastic syndromes and the clinical implications of TP53 mutations predicting outcomes in del(5q) MDS.

Neoadjuvant Chemotherapy for Muscle Invasive Bladder Cancer: Is it Ready for Prime Time? from 2011-04-18T17:18:02

This podcast describes the long term outcomes of patients treated with chemotherapy first, followed by either cystectomy or radiation therapy. It provides important information to practicing physic...

Are Lung Cancers with BRAF Mutations Another Molecularly Defined Subgroup of Patients? from 2011-04-11T18:01:31

In this week's podcast, Dr. Jaine discusses the recent manuscript by Paik and colleagues evaluating BRAF mutations in patients with advanced lung cancer. The potential impact of BRAF mutations and ...

Targeting the VEGF Receptor in Colon Cancer: Lessons Learned from Negative Trials from 2011-04-04T17:57:48

In this podcast, Dr. Neal J. Meropol provides his perspective on two large randomized studies of vatalanib in patients with metastatic colorectal cancer.

The Performance of Breast MRI Screening Among Women with BRCA1/2 Mutations from 2011-03-28T21:07:15

By Mary Daly. Stage at diagnosis of breast cancer among women with BRCA1/2 mutations was available for women enrolled in a multi-modality screening protocol including breast MRI, and for women who...

Circulating Tumor Cells in Resectable Colorectal Cancer from 2011-03-24T15:53:14

By David Ryan. This JCO Podcast provides observations and commentary on the JCO article, "Clinical Significance of Circulating Tumor Cells Including Cancer Stem-like Cells in Peripheral Blood for ...

Results From a Phase I Trial of TG101348, a Selective JAK2 Inhibitor with Significant Activity in Symptomatic Myelofibrosis Patients from 2011-03-17T18:36:30

By Reed Drews. This JCO Podcast provides observations and commentary on the JCO article, "Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis" by authors Animesh Pardanani...

RIBBON-1 Revisited from 2011-03-17T18:36:29

By Lisa Carey. The randomized Phase III trial, Ribbon-1, was designed to examine whether the benefit of bevacizumab added to chemotherapy in metastatic breast cancer was specific to the taxanes or...

Noninferiority of Denosumab As Compared With Zolendronic Acid With Respect to the Ability to Delay Skeletal Events in Patients With Solid Tumors and Multiple Myeloma from 2011-03-17T18:36:28

By David Avigan. This podcast describes a phase III randomized study comparing the efficacy and toxicity of Denosumab with Zolendronic Acid for the prevention of skeletal complications in patients...