Hematologic Oncology | Oncology Today with Dr Neil Love: Key Presentations on Myeloproliferative Neoplasms from the 2020 ASH Annual Meeting - a podcast by Dr Neil Love

from 2021-02-12T19:15

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Featuring an interview with Dr Aaron T Gerds on the following topics:

  • Biologic rationale for the use of JAK inhibitors; key data supporting the FDA approval of ruxolitinib and fedratinib for myeloproliferative neoplasms (MPN) (0:00)
  • Real-world survival among patients with intermediate- to high-risk myelofibrosis (MF) in the United States: Impact of ruxolitinib approval (3:09)
  • Effect of ruxolitinib for inadequately controlled polycythemia vera (PV) without splenomegaly: Five-year results from the Phase III RESPONSE-2 study (5:27)
  • Long-term safety of fedratinib for patients with intermediate- or high-risk MF (8:31)
  • Activity and tolerability of momelotinib in patients with MF (11:37)
  • Choice of JAK inhibitor for patients with MF (15:38)
  • Risks and benefits with fedratinib for patients with MF who experience disease progression on ruxolitinib (23:05)
  • Clinical experience with fedratinib in the treatment of MF (26:12)
  • Improvement in survival outcomes, symptoms and quality of life with JAK inhibitors (34:33)
  • Activity and tolerability of the telomerase inhibitor imetelstat in patients with intermediate 2- or high-risk MF that is relapsed or refractory to JAK inhibitors (39:16)
  • Navitoclax with ruxolitinib in different populations of patients at high risk with relapsed/refractory MF (46:35)
  • Role of ruxolitinib in therapy for patients with essential thrombocythemia and PV; effect of the hepcidin mimetic PTG-300 on treatment for PV (55:14)
  • Efficacy of eprenetapopt (APR-246), a small molecule reactivator of mutant and inactivated p53, for myelodysplastic syndromes (MDS) with TP53 mutation (59:44)
  • Hypomethylating agents in combination with venetoclax for elderly patients with acute myeloid leukemia (AML) (1:01:43)
  • Benefits and risks of CPX-351 for patients with AML (1:08:21)
  • Ongoing investigation of the oral combination of decitabine and cedazuridine for AML (1:10:30)
  • Perspective on CC-486 (oral azacitidine) as maintenance therapy for patients with AML (1:13:08)
  • Role of luspatercept for the treatment of anemia associated with MDS (1:16:01)

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