Hepatocellular Carcinoma | Tim Greten, MD - a podcast by Dr Neil Love
from 2020-04-13T20:19:46
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Hepatocellular Carcinoma Update, Issue 1, 2020 — Part 2: Our interview with Dr Greten highlights the following topics as well as cases from his practice:
- Adjuvant treatment of HCC: Prospect for immunotherapy (00:00)
- Immune landscape of the liver and role of the microbiome (04:18)
- Ongoing trials evaluating immunotherapy in the (neo)adjuvant setting for patients with HCC (07:04)
- Role of immunotherapy and targeted therapy in the management of cholangiocarcinoma (09:49)
- Mechanism for the synergy between immune checkpoint inhibitors and anti-angiogenic therapies (11:16)
- Perspective on an antibody- versus a tyrosine kinase inhibitor-based approach to targeting VEGF (14:00)
- Development of shellfish allergy after exposure to dual immune checkpoint blockade with durvalumab and tremelimumab (17:03)
- Spectrum of immune-related adverse events associated with checkpoint inhibitors (18:47)
- Background and design of the Phase III IMbrave150 trial (20:03)
- Exclusion of patients with bleeding or high risk of bleeding with untreated varices from the IMbrave150 trial (21:34)
- IMbrave150: Activity and tolerability of atezolizumab/bevacizumab versus sorafenib (24:32)
- Historical response rates with single-agent tyrosine kinase inhibitors or anti-PD-1/PD-L1 antibodies (27:46)
- Potential clinical role of atezolizumab/bevacizumab as first-line therapy for patients with advanced HCC (28:56)
- Selection and sequencing of therapies for patients with HCC (31:27)
- Ongoing investigation of immune checkpoint inhibitor combinations (34:05)
- Activity of immune checkpoint inhibitors in patients with HCC (35:57)
- Case: A man in his mid-60s with a history of hepatitis C receives cabozantinib for metastatic HCC after experiencing disease progression on lenvatinib and pembrolizumab (38:19)
- Side effects associated with sorafenib and lenvatinib (41:11)
- Efficacy and tolerability of pembrolizumab for HCC (43:51)
- Approach to first- and second-line treatment for HCC (47:56)
- Case: A man in his early 40s with chronic hepatitis B and metastatic HCC has no evidence of disease after treatment with pembrolizumab and surgical resection (50:55)
- Case: A man in his mid-40s with uncontrolled hepatitis C develops transaminitis after treatment with sorafenib for HCC (55:14)
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