Triple-Negative Breast Cancer | Data + Perspectives: Clinical Investigators Explore the Current and Future Management of Triple-Negative Breast Cancer - a podcast by Dr Neil Love
from 2020-03-03T14:20:55
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Proceedings from a satellite symposium during the 42nd annual San Antonio Breast Cancer Symposium. Featuring perspectives from Dr Erika Hamilton, Prof Sherene Loi, Dr Mark E Robson and Dr Hope S Rugo.
- Introduction
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- Program Overview: Dr Love (00:00)
- Established Management Paradigms for Advanced Triple-Negative Breast Cancer (TNBC); Actionable and Other Potentially Relevant Biomarkers to Inform Decision-Making
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- Case (Dr Loi): A woman in her early 40s with PD-L1-positive metastatic TNBC (mTNBC) and a germline BRCA mutation (01:11)
- Case (Dr Robson): A woman in her early 40s with PD-L1-positive mTNBC experiences disease progression on atezolizumab/nab paclitaxel and is considering next steps (09:29)
- Faculty Presentation: Dr Hamilton (14:16)
- Immune Checkpoint Inhibition as a Rational Therapeutic Strategy for Advanced TNBC
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- Case (Dr Hamilton): A woman in her mid-50s with mTNBC achieves a complete response to atezolizumab/nab paclitaxel on the IMpassion130 trial (26:59)
- Faculty Presentation: Dr Rugo (34:22)
- Available Data with and Practical Integration of PARP Inhibition into the Care of Patients with mTNBC
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- Case (Dr Rugo): A woman in her early 30s with TNBC and a BRCA1 mutation has extensive residual disease after neoadjuvant chemotherapy and receives olaparib (54:25)
- Case (Dr Hamilton): A woman in her early 60s with mTNBC and a germline BRCA2 mutation experiences gastrointestinal toxicities and cytopenias while receiving olaparib (56:28)
- Faculty Presentation: Dr Robson (58:34)
- Novel Applications of Immune Checkpoint Inhibitors Alone or in Combination with Other Agents for Patients with Early and Advanced TNBC; Other Promising Agents in Late-Stage Clinical Trials
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- Case (Dr Rugo): A woman in her late 50s with TNBC experiences prolonged stable disease after receiving adjuvant capecitabine followed by pembrolizumab (1:11:49)
- Case (Dr Robson): A woman in her early 40s initially diagnosed with TNBC and a germline BRCA mutation presents 8 years later with node-positive contralateral TNBC (1:14:53)
- Faculty Presentation: Prof Loi (1:19:45)
CME information and select publications
Further episodes of Research To Practice | Oncology Videos
Further podcasts by Dr Neil Love
Website of Dr Neil Love