Podcasts by The Bio Report
The Bio Report podcast, hosted by award-winning journalist Daniel Levine, focuses on the intersection of biotechnology with business, science, and policy.
Further podcasts by The Bio Report
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Gene Therapy Provides Hope to Hemophilia B Patients from 2022-02-17T09:00:24
In 2020, CSL Behring entered into a global license and commercialization agreement with UniQure for the company’s experimental hemophilia B gene therapy. The expected, one-and-done treatment carrie...
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Making Data-Driven Medicine a Reality from 2022-02-10T09:00:17
The promise of data-driven medicine is that it can accelerate the diagnosis of disease, provide patients with the most effective treatments for their particular conditions, and improve drug develop...
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A Neuroscientist Turned Venture Investor Discusses TechBio Investing from 2022-02-03T09:00:25
The growing convergence of information technology and biotechnology are creating a compelling new group of companies that live in both these worlds at once. Lux Capital, which has long invested in ...
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A Nonprofit Seeks to Make Cell and Gene Therapies Affordable Worldwide from 2022-01-27T09:00:14
Cell and gene therapies are among the most promising approaches to treating diseases because they carry the potential to cure chronic and progressive conditions. The problem is that the high cost o...
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Disposing Toxic Proteins to Treat Neurodegenerative Diseases from 2022-01-20T09:00:28
KeifeRx is developing a pipeline of orally delivered tyrosine kinase inhibitors to treat neurodegenerative diseases. It has a portfolio of these drugs that it has optimized to penetrate the brain, ...
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Repurposing a Drug for Parasitic Infections as a Targeted GI Therapy from 2022-01-13T09:00:18
When AzurRX BioPharma merged with First Wave Bio last year it renamed itself First Wave BioPharma. The company is developing targeted, non-systemic therapies for gastrointestinal diseases with its ...
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Targeting Chronic, Low-Grade Inflammation to Address Diseases of Aging from 2022-01-06T09:00:12
HCW Biologics is developing immunotherapies to target chronic inflammation associated with aging. The company’s therapeutics are designed to disrupt the link between chronic, low-grade inflammation...
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The Year in Biotech and What's Ahead in 2022 from 2021-12-30T09:00:22
As 2021 fades into the history books, it will be remembered as one with exuberant IPOs, punishing aftermarkets, and a lingering pandemic that once again is turning the annual JPMorgan Healthcare Co...
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Restoring the Guardian of the Genome to Fight Tumors from 2021-12-23T09:00:26
The p53 protein is known as the “guardian of the genome.” It plays an essential role in suppressing tumors. Rain Therapeutics is targeting a regulator of p53 that is overexpressed in certain cancer...
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Advancing a Cell Therapy with the Potential to Cure HIV from 2021-12-16T09:00:10
Though HIV has fallen out of the headlines, the virus continues to represent a significant public health threat. American Gene Technologies is developing an experimental cell therapy that it says i...
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Harnessing More Efficient Organisms to Reshore BioManufacutring from 2021-12-09T09:00:22
The COVID pandemic has called attention to the United States’ reliance on a supply chain that makes access to critical medicines dependent on the ability to make them overseas and ship them in a ti...
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Using Digital Health Technology to Bring the Trial to the Patient from 2021-12-02T09:00:12
The use of smartphones, low-cost sensors, and ubiquitous connectivity is changing the way researchers think about recruiting, monitoring, and interacting with participants in biomedical research. T...
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Using the Body’s Housecleaning Mechanism to Target Undruggable Proteins from 2021-11-24T09:00:29
The body has a natural cellular recycling machinery known as the ubiquitin proteasome system that breaks down unwanted proteins. Kymera Therapeutics has developed a drug discovery platform that exp...
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Advocating for the Extension of Healthy Life from 2021-11-18T09:00:11
About 70 percent of daily deaths are caused by aging or age-related diseases. The newly formed Alliance for Longevity Initiatives, or A4LI, is an independent nonprofit advocating for greater invest...
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Using Donated Living Skin as an Alternative to Animal Testing from 2021-11-11T09:00:11
As concerns about the use of animals to test drugs, scientist have sought new ways to analyze the efficacy and toxicity of their products. Genoskin is seeking to enable better, faster, and safer dr...
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A Platform to Scale the Production of Personalized Cell Therapies from 2021-11-04T08:00:24
While cell therapies have been advancing rapidly, therapies that rely on taking a patient’s own cells, altering them, and reinfusing them back into a patient are costly. Part of the reason why is t...
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Developing Small Molecule Therapies to Target Proteins Only Biologics Have Been Able to Hit from 2021-10-28T08:00:24
Integrins are a diverse family of proteins that play an essential role in many cellular biological processes. They also have been implicated a number of autoimmune, cardiovascular, and metabolic di...
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Targeting Solid Tumors with Oncolytic Viruses from 2021-10-20T21:30:45
As the treatment of cancers has moved toward an increasing emphasis on the role the immune system can play in fighting tumors, a range of new ways to enlist and train the immune system have emerged...
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Reinventing the Discovery and Cell Line Development of Biotherapeutics from 2021-10-14T08:00:17
The discovery and cell line development of biotherapeutics has been traditionally a distinct process. Absci is taking what it describes as a more wholistic approach by collapsing the process down a...
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Engineering Off-the-Shelf Cell Therapies to Target Solid Tumors from 2021-10-07T08:00:27
While CAR-T cell therapies have been a promising new area of cancer treatments, they are costly to produce, have had limited success in treating solid tumors, and can carry sometimes serious side e...
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Democratizing Drug Discovery from 2021-09-30T08:00:46
The ability to discover new drugs can be limited by the tools and technologies small companies can access. Alloy Therapeutics says it democratizing access to a set of technologies and capabilities ...
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Scaling Genetic Counseling Services with AI from 2021-09-23T08:00:16
One of the consequences of the proliferation of genetic sequencing has been a shortage of genetic counselors. It’s left existing counselors to manage a heavy load as its increased the demands on on...
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Programming Cell Therapies to Overcome Solid Tumor Defense Systems from 2021-09-16T08:00:26
While CAR-T cell therapies have emerged as promising anti-cancer agents, their success have been focused on hematologic cancers. ArsenalBio is working to develop more robust cell therapies capable ...
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Using Liquid Biopsies to Diagnose Infectious Diseases from 2021-09-09T08:00:17
Liquid biopsies have become associated with the area of oncology as they hold the promise of using fragments of DNA circulating in the blood that have been shed by tumors to provide early indicatio...
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Striking Hepatitis B at Its Core from 2021-09-02T08:00:25
The World Health Organization estimates that 270 million people worldwide suffer from chronic hepatitis B virus infections, making it a global epidemic that affects more than twice the number of pe...
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Modulating Serotonin with Psychedelics to Treat Neuropsychiatric Conditions from 2021-08-26T08:00:25
Psychedelics have become an area of increasing investment and drug development activities as an emerging group of companies is working to develop these compounds as treatments for neurologic and ps...
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A Procedural Therapy Seeks to Address Type 2 Diabetes at Its Root Cause from 2021-08-19T08:00:15
Type 2 diabetes affects nearly 500 million people worldwide and more than 34 million people in the United States. The disease carries an elevated risks of heart attack, stroke, and other serious co...
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Building a Better Path to Neurotherapeutics from 2021-08-12T08:00:26
The efforts to develop drugs for neurologic and psychiatric conditions has been plagued with failure. Herophilus is combining organoids derived from patient stem cells along with machine learning t...
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Taking a Portfolio Approach to Immuno-Oncology from 2021-08-05T08:00:14
While the class of immunotherapies known as checkpoint inhibitors has brought a promising new approach to treating cancer, the development of resistance to these therapies limits the number of pati...
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Engineering Life to Reach New Worlds from 2021-07-29T08:00:21
Earth will not live forever. Whether its destruction comes as the result of cosmic inevitability or human-caused cataclysm, the planet will eventually meet its demise. Though that may be billions o...
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Targeting Cancer Drug Side Effects at Their Source from 2021-07-22T08:00:20
While great strides have been made the fight against cancer with new therapies, dose-limiting toxicities of these agents can have a big impact on the quality of life for patients and lead doctors t...
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Mapping the Universe of Human Proteins from 2021-07-15T08:00:26
While great progress has been made in understanding the human genome, its functional counterpart, the human proteome, remains relatively unexplored. In part, that’s because advances in the tools to...
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Fighting Disease by Modulating the Translation of Proteins from 2021-07-08T08:00:22
The development of mRNA therapies is allowing drug developer to pursue targets once considered undruggable. Anima Biotech has developed a platform that allows it to use small molecule that selectiv...
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Fixing Biopharma's R&D Productivity by Taking a Cue from the Tech Industry from 2021-07-01T08:00:30
The biopharmaceutical industry has long struggled with R&D productivity. Long time industry strategic consultant Mike Rea, founder and CEO IDEA Pharma, thinks he’s hit on a possible solution. Takin...
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An Affordable and Widely Available Drug Offers Global Hope against COVID from 2021-06-24T08:00:29
While cities across the country have lifted COVID-19 restrictions and public gatherings have returned, the lack of effective treatments for people who develop severe reactions to the virus continue...
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A Gene Therapy to Program the Body to Produce a Treatment for Osteoarthritis from 2021-06-17T08:00:23
Osteoarthritis is a painful, progressive disease of the joints for which there is no cure. The condition affects more than 32.5 million adults in the United State and the incidence is growing as a ...
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A Test for Data-Driven Drug Development from 2021-06-10T08:00:23
Sumitomo Dainippon Pharma’s $3 billion strategic transaction with Roivant Sciences that gave rise to Sumitovant, represents an effort by the Japanese drug company to make the drug development proce...
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Bridging the Gulf Between the Promise and Reality of Precision Health from 2021-06-03T08:00:21
The ability to identify diseases at their earliest stages through the detection of minute levels of biomarkers offers the potential to make interventions before the outward physical manifestations ...
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Using Synthetic Biology to Craft One-Time, Programmable mRNA Therapeutics from 2021-05-27T08:00
The marriage of synthetic biology to mRNA is creating the potential for a range of programmable therapeutics that can provide new ways of treating deadly and chronic diseases. Strand Therapeutics i...
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Using a Digital Cognitive Behavior Therapy to Treat Diabetes and Heart Disease from 2021-05-20T03:27:39
Cardiometabolic conditions, such as type 2 diabetes and heart disease, have long been treated with pharmacologic interventions. Better Therapeutics believes cognitive behavioral therapy delivered t...
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Disrupting Pain Signals with Precision from 2021-05-12T23:41:47
The side effects of opioids and the potential for addiction underlies the need for new approaches to the treatment of pain. SiteOne therapeutics is developing a pipeline of therapies that target so...
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A Diagnostics Company Moves to Developing Precision Cancer Therapies from 2021-05-06T08:00:11
Earlier this year NovelluxDx rebranded itself as Fore Biotherapeutics signaling a shift from being a diagnostics company to its new life as a precision cancer therapeutics drug developer. Building ...
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Characterizing the Immunome at Scale from 2021-04-29T08:00:12
When variants of the COVID-19 virus emerged in late 2020, it raised concerns about whether people already infected with the original virus, or vaccinated against it, would be able to generate a pro...
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Delivering Oxygen to Tissue in Need from 2021-04-22T08:00:11
Hypoxia, a potentially fatal shortage of oxygen in tissues, is a complicating factor in a variety of serious illnesses including cancer, cardiovascular disease, and respiratory conditions. Diffusio...
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Using Gene Therapy to Create a Drug Biofactory within a Patient from 2021-04-15T08:00:26
Wet age-related macular degeneration is a progressive disease and a leading cause of vision loss in patients over the age of 60. Vision loss is caused by the leakage of blood and other fluid from a...
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Finding New Uses for TNF Inhibitors from 2021-04-08T08:00:11
TNF inhibitors, such as Humira and Remicade, have been a great biotech success story. These multi-billion franchises treat a range of autoimmune conditions including rheumatoid arthritis, psoriasis...
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Using AI to Map the Undiscovered World of Bioactive Compounds in Plants from 2021-04-01T22:36:11
The plant world has been a ready source of bioactive compounds that can improve human health. There are more than 10 million natural compounds in the plant world, but less than 0.1 percent of these...
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Improving the Delivery of Drugs through Thin Film Freezing from 2021-03-25T08:00:30
TFF Pharmaceuticals thin film freezing technology allows it to take vaccines, small molecule drugs, and biologics and turn them into a fine powder. The process not only can be used to eliminate the...
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Using CRISPR to Target RNA Instead of DNA from 2021-03-18T08:00:03
The gene editing technology CRISPR-Cas9 is being harnessed to alter DNA, but Locanabio is using it to create a new class of genetic medicines that can precisely target and modify dysfunctional RNA....
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An Antisense Pioneer Brings Custom Treatments to Patients with Ultra-Rare Conditions from 2021-03-11T09:00:28
In January 2020, antisense pioneer and Ionis Pharmaceuticals founder Stanley Crooke launched a nonprofit to design and deliver custom RNA-targeted therapies free of charge for individual patients w...
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Managing Neurodegenerative Diseases with Better Data to Improve Outcomes from 2021-03-04T09:00:22
Octave Bioscience is seeking to transform the way neurodegenerative diseases are managed by providing new insights into the severity of a patient’s condition, its progression, and using evidence-ba...
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A Small Molecule Cancer Drug That Promotes an Adaptive Immune Response from 2021-02-25T09:00:28
Phosplatin Therapeutics is developing a class of small molecule cancer therapies designed to avoid the problems of drug resistance and toxicity associated with chemotherapies. The company’s lead ex...
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Sloan-Kettering Spin-Out Harnesses AI to Diagnose Cancer from 2021-02-18T09:00:25
Earlier this year Paige, a company developing artificial-intelligence driven pathology platforms for the diagnosis of cancer, raised $100 million in a series C venture round. The funding came a mon...
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Bringing Innovation to Cell and Gene Therapy Manufacturing from 2021-02-11T09:00:22
While cell and gene therapies represent an area of great therapeutic promise, current manufacturing process are expensive and difficult to scale. As a result, this creates bottlenecks that limit pa...
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Tapping Psychedelics for their Anti-Inflammatory Powers from 2021-02-04T09:00:28
There’s been a growing industry effort to explore the use of psychedelics for their medicinal benefits. While much of these efforts have looked to these drugs to treat a range of psychiatric condit...
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Advancing Cell Therapies Beyond Cancer from 2021-01-28T01:54:13
Regulatory T cell therapies have been pursued as treatment for cancers, but Sonoma Biotherapeutics believes these cells can be harnessed to delivery lasting and potential curative treatments for au...
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How the Pandemic Transformed a Small Diagnostics Company from 2021-01-21T09:00:19
For more than 15 years, Longhorn Vaccines & Diagnostics has been designing and developing products for potential pandemics in developing economies. The recent COVID-19 pandemic, though, put the sca...
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Eliminating Security, Privacy, and Regulatory Burdens with Synthetic Data from 2021-01-14T09:00:19
There are many reasons why the sharing of medical data that could be used to gain new insight into diseases can be hampered. Privacy concern, regulatory burdens, and the need to manage security ris...
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Using Computational Discovery to Build Better Immunotherapies from 2021-01-07T09:00:10
While checkpoint inhibitors represent a class of promising new therapies to treat cancer, the efficacy of these immunotherapies have been limited because of the ability of cancers to develop resist...
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The Year in Biotech and What's Ahead in 2021 from 2020-12-31T09:00:24
The raging pandemic defined 2020, but it was a big year for biotech as the industry saw soaring stocks, record investment, and an impressive number of new drug approvals despite disruptions from CO...
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Bringing Precision Cancer Care to Dogs from 2020-12-24T09:00:28
The case for precision medicine to treat cancer has been clear. Understanding the molecular underpinnings of a patient’s cancer can allow doctors to use targeted therapies that can best address the...
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As COVID-19 Vaccines Ship, One Company Brings Innovation to the Vials from 2020-12-17T09:00:20
As potential vaccines for COVID-19 approached approval, the focus has been on the safety and efficacy of candidates. Now that vaccines have been approved, attention has been shifting to the complex...
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Advancing an Antibody to Prevent and Treat Cytokine Storms in COVID-19 from 2020-12-10T09:00:20
There are many approved or experimental therapies in development for a range of indications that, because of their mechanisms of action, have been pursued as potential therapies to treat patients w...
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Using AI Created Digital Twins to Accelerate Clinical Trials from 2020-12-03T09:00:25
One of the challenges of conducting clinical trials is finding enough patient to include in a control arm of a study. This can slow the pace of drug development and increase its costs. Unlearn.AI i...
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Modulating RNA to Quell Disease from 2020-11-26T09:00:12
Traditional efforts to treat autoimmune conditions have focused on inhibiting proteins involved in the immune response. Abivax is developing therapies that modulate RNA to enhance the body’s natura...
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A Quest to Extend Life through Early Disease Detection from 2020-11-19T09:00:11
Jo Bhakdi wants to build a future where people are protected against most diseases through early detection. His company Quantgene, which marries artificial intelligence with the ability to detect c...
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Modulating a Gatekeeper of Cellular Metabolism to Treat a Range of Diseases from 2020-11-12T09:00:28
A gatekeeper of cellular metabolism known as mTORC1 underlies a wide range of age-related diseases. Navitor Pharmaceuticals is developing therapies that can modulate the mTORC1 complex and allow fo...
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Finding the Best Cell for the Job from 2020-11-05T09:00:24
Whether it is cells engineered to provide therapeutic benefits or biomanufacturing processes to replace energy-intensive and toxic chemical byproducts of industrial manufacturing, getting the right...
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Transforming Clinical Trials with Digital Technology from 2020-10-29T08:00:24
Glen de Vries in his new book "The Patient Equation" says that despite the digital revolution in the way we can capture and analyze data, not much has changed for decades in the how clinical trials...
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Designing Immunotherapies that Can Overcome Recurrence and Resistance from 2020-10-22T08:00:16
While immunotherapies carry great promise for improving outcomes for people with cancer, the ability of cancers to evade the immune system and develop resistance limits their benefits as monotherap...
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Extending Precision Medicine Beyond Cancer from 2020-10-15T08:00:24
While the potential for precision medicine has excited drug developers and clinicians with the promise of delivering more meaningful therapies to patients, the advent of these medicines has largely...
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Growing Biologics from 2020-10-08T08:00:17
Zea Biosciences is not a typical contract manufacturing organization. The company uses plants to grow recombinant proteins for biologic therapies. To produce a consistent and predictable product, Z...
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An Experimental COVID-19 Vaccine Begins Human Clinical Trials from 2020-10-01T08:00:34
United Biomedical has long been in the business of producing animal vaccines, but in recent years it has turned its attention to developing vaccines for chronic human diseases including neurologica...
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Speeding the Delivery of CAR-T Therapies While Cutting the Cost from 2020-09-24T08:00:14
CAR-T therapies are an area of great promise for improving outcomes for cancer patients, but the process of preparing cells taken from a patient and genetically modifying them is time consuming and...
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Transforming Infused Biologics into Injectables from 2020-09-17T08:00:18
The administration of biologics can be challenging because of the sheer volume of product needed to deliver a dose to a patient. It is for this reason that many of these therapies must be infused i...
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A Novel Approach to NASH That May Have Benefits for COVID 19 As Well from 2020-09-10T08:00:23
NASH, a form of fatty liver disease, causes progressive damage and can lead to inflammation, fibrosis, and the development of cancer. It has become an increasing health concern as the Western diet ...
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Will a Focus on Protein Dysregulation Help Prothena Break from the Fold from 2020-09-03T09:00:27
The complexity of neurodegenerative diseases has made it a challenging area for drug developers. Gene Kinney, CEO of Prothena, has long been involved in the pursuit of therapies for diseases such a...
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After FDA Set Back, AI Driven Drug Company Advances with New CEO from 2020-08-27T17:29:47
The U.S. Food and Drug Administration delivered a blow to Pharnext in 2019 when it told the company it should conduct an additional late-stage study of its experimental therapy for the rare neurolo...
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A Gamified Therapy System Helps People with Brain Injury Recover from 2020-08-20T11:00:35
MindMotion GO is a first-of-its-kind mobile neurorehabilitation therapy system that helps people regain motor and task functions through a gamified approach. While the game playing aspects of the t...
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Genentech Drug Offers Oral, at-Home Option for SMA Patients from 2020-08-13T18:31:10
People with the rare and fatal genetic disease spinal muscular atrophy in recent years have seen the approval of an antisense therapy as well as a gene therapy. Genentech has now won U.S. Food and ...
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Enabling Precision Medicine through Proteomics from 2020-08-06T18:30:27
While the revolution in genomics has led to rapid improvements in the cost and speed of sequencing and created new insights into the genetic drivers of health and wellness, proteomics has lagged be...
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Battling Drug-Resistant Fungal Infections from 2020-07-30T08:00:26
The problem of drug resistance isn’t limited to bacteria. It is also a growing concern with fungal species that is causing an increasing need for new agents to combat these microbes. Scynexis is de...
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Making Colorectal Cancer Screening Less of a Pain in the Ass from 2020-07-23T17:26:53
Colorectal cancer is the third most common form of the cancer. While screening is an effective means of preventing it, many people fail to get a colonoscopy because of the invasive nature of the pr...
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Targeting Diseases of Aging at a Cellular Level from 2020-07-16T09:00:36
To see the affects of aging all you have to do is look in a mirror and watch the changes over time. Fountain Therapeutics is training its artificial intelligence platform to look at individual cell...
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Cracking the Immune System with AI from 2020-07-09T11:00:25
The emergence of immunotherapies has represented a powerful addition to the cancer arsenal, but frequently they fail to deliver benefits to patients. Understanding what therapies will benefit which...
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Using AI to Improve Drug Companies’ Regulatory Performance from 2020-07-02T16:48:57
Artificial intelligence is working its way into all aspects of pharmaceutical companies’ operations. While much attention has been given to the role these systems can play in drug discovery, IQVIA ...
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Delivering Biologics Orally from 2020-06-25T18:49:16
Delivering biologics orally rather than through injection has been an intriguing goal but has proven difficult. Most efforts have focused on finding ways to turn these large protein molecules into ...
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Turning Proteins into Device Coatings that Provide Therapeutic Benefits from 2020-06-18T19:12:05
Luis Alvarez, a West Point graduate who earned a Ph.D. in bioengineering from MIT, served 20 years in the military including time as an intelligence officer in Iraq. He saw injured soldiers who doc...
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Testing if an Approved Antiviral May Prevent COVID-19 Outbreaks from 2020-06-11T16:41:43
Last month, Canadian regulators provided clearance for Appili Therapeutics to begin a phase 2 study of an approved antiviral therapy as a potential preventative treatment against COVID-19 outbreaks...
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Using AI to Crack COVID-19 from 2020-06-04T04:06:38
The urgency to find treatments for the COVID-19 virus has allowed researchers to set aside institutional bureaucracy and companies to apply their technologies in new ways. One example of this is Sc...
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Why An Experimental Therapy for Inflammatory Disorders Could Help the Fight Against COVID-19 from 2020-05-28T00:38:32
As a researcher, Joe Garcia applied functional genomics to understanding genes that contribute to inflammatory disorders such as acute respiratory distress syndrome, or ARDS. As founder and CEO of ...
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Modernizing Phage Therapy to Kill Multidrug-Resistant Bacteria from 2020-05-21T01:57:51
Bacteriophages have long been used to treat infections. These naturally occurring virus are capable of killing bacteria, but each strain of phage is highly specific. Because of their unique mechani...
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A Rare Disease Drug Hunter Turns His Attention to COVID-19 from 2020-05-14T08:00:13
As a medical student, David Fajgenbaum nearly died from Castleman disease, a rare autoimmune condition. He would suffer recurring bouts that carried him to the brink of death but was able to push t...
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What It Will Take to Move Beyond the Pandemic from 2020-05-06T22:50:27
As some jurisdictions move to lift shelter in place orders and seek to restore economic life to normal, there’s growing concerns about the health consequences of moving too fast and the failure to ...
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Reading, Writing, and Erasing the Way to Epigenetic Cancer Therapies from 2020-04-30T12:00:29
Targeting the epigenome—the regulators that turn on and off the activity of genes—has long been viewed as a promising way to treat cancer. But despite the promise of this approach, early efforts br...
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Better Immunotherapies Through Chemistry from 2020-04-23T11:00:23
Acepodia has developed platform technology that allows it to chemically modify or conjugate living cell surfaces. The technology can be applied to any immune cell and any antibody or binding protei...
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Bringing the Trial to the Patient from 2020-04-16T19:23:14
One of the challenges to securing the participation of patients in clinical trials can be simple geography. Sanguine Biosciences is seeking to tear down that barrier to participation by using mobil...
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Controlling the Activity of Cell and Gene Therapies with Precision from 2020-04-09T17:36:19
One of the challenges cell and gene therapies pose is how to control how much and when a desired protein is delivered. Obsidian Therapeutics has developed a platform that allows a small molecule dr...
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Why Soon-Shiong Thinks His Triangle Offense for Cancer Can Be Applied to COVID-19 from 2020-04-02T16:21:20
Patrick Soon-Shiong likes to talk about the “triangle offense,” the activation of a combination of macrophages, natural killer cells, and memory T-cells to battle cancer. He believes the same appro...
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COVID-19, Vaccine Development, and Global Health Lessons from Ebola from 2020-03-25T21:24:32
The COVID-19 pandemic is threatening to stress healthcare systems throughout the world and it is making the development of a vaccine an important part of a strategy to arrest the virus. Though clin...
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Improving Cancer Outcomes with Early Diagnosis from 2020-03-19T19:33:47
Early detection is a critical means of improving outcomes for cancer patients. When cancer is detected at stage I, patients have a 90 percent chance of survival. By contrast, if cancer is diagnosed...
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Making A Social Contract That's Enforceable from 2020-03-12T20:15:17
As the debate over drug pricing intensifies, biotech investor Peter Kolchinsky is weighing in with a proposed approach to balance access to medicines with the incentive for companies to invest in t...
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Treating Alzheimer's Disease as an Autoimmune Condition from 2020-03-05T18:34:59
There is growing scientific evidence suggesting that Alzheimer’s disease may be an autoimmune condition. Whether it is or not may be an unsettled issue, but targeting neuroinflammation associated w...
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Fishing for New Drugs from 2020-02-27T13:00:20
The Gloucester Marine Genomics Institute is seeking to harness biotechnology to discover new therapeutics by studying the DNA of marine life. At the same time, the institute hopes to breathe new li...
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Thoughts on the State of the Antimicrobial Arsenal from 2020-02-20T19:58:33
The latest reports on the coronavirus outbreak put the number of infections at nearly 75,000 and deaths at more than 2,100. Against the backdrop of the outbreak, we spoke to Evan Loh, chairman of t...
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A MedTech Company That Thinks Like a Biopharma from 2020-02-13T17:51:13
Orchestra BioMed may play at the intersection of drugs and devices, but’s its business strategy is clearly drawn from the biopharmaceutical industry. The company develops its pipeline and then leve...
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Tapping the Potential of Psychedelics to Treat Psychiatric Conditions from 2020-02-06T17:01:56
Psychedelics have long been viewed as having potential to treat a range of mental health disorders including depression, addiction, PTSD, and ADHD. Government policies, though, have long impeded st...
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Quantifying Neurodegeneration with Precision from 2020-01-30T13:00:10
The difficulty in diagnosing Alzheimer’s disease and identifying it at its earliest stages when interventions offer the best opportunity for success, is one of the critical challenges in addressing...
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Orasis Developing Eye Drops as Alternative to Reading Glasses from 2020-01-23T18:31:31
As people age, the ability of their eyes to focus on objects near to them weakens. The condition, known as presbyopia, affects more than 1.8 billion people worldwide. Though reading glasses provide...
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Reversing Disease Signals from 2020-01-16T19:56:02
Ben Zeskind likens Immuneering’s platform technology to noise-cancelling headphones. Infact, the company’s use of the term “Disease Cancelling Technology” speaks directly to that. The approach, he ...
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Turning Cold Tumors Hot from 2020-01-09T21:24:32
One reason immunotherapies fail is because of the ability to tumors to alter the microenvironment in which they exist and hide themselves from detection by the immune system. In some indications, a...
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Stabilizing Neuronal Connections to Treat Cognitive Impairment in Alzheimer's from 2020-01-02T19:56:41
The brain converts short-term memories into long-term memories through the formation and stabilization of new connections between neurons. Tetra Therapeutics is working to treat cognitive impairmen...
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Our Annual Biotech Review/Preview with STAT's Adam Feuerstein from 2019-12-26T19:07:20
A holiday tradition at The Bio Report is to take a moment to reflect on the year past and look ahead to the new year with Adam Feuerstein, senior writer and national biotech columnist for STAT. We ...
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An Effort to Eradicate Preventable Blindness from 2019-12-20T20:19:05
We spend a lot of time on The Bio Report talking about innovation. We are living at a time of great scientific advances that are translating into remarkable therapies that are changing people’s liv...
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Seeking Success Where Others Have Failed from 2019-12-19T18:59:58
Inhaled insulin has been one of those biotech ideas that have seemed better on paper than in practice. Huge investments have been made to carry these products through challenging development only t...
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A New Antibiotic with a Unique Mechanism of Action Hits the Market from 2019-12-12T18:57
In August, Nabriva Therapeutics won U.S. Food and Drug Administration approval for Xenleta for the treatment of community-acquired bacterial pneumonia in adults. It was the first new antibiotic wit...
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Improving Health with Better Data from 2019-12-05T18:36:08
Healthcare decisions are often flawed because of the limited information on which they are based. But with the growing ability to capture massive amounts of data digitally and apply artificial inte...
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An Effort to Bioprint a Transplantable Human Heart from 2019-11-28T19:34:34
In the United States, more than 100,000 people are on a transplant waiting list and many other simply do not qualify. In 2009, 25 people per day died while on the waiting list. Transplant procedure...
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How Doctors Are Cracking Difficult Cases with a Social Network from 2019-11-21T13:00:03
Sermo describes itself as a “virtual doctors’ lounge” where physicians can express their opinions and interact with other doctors. One of the newer features on the physician-only social network is ...
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Cala Health Hopes to Win Over Payers and Providers with Its Bioelectric Medicine from 2019-11-14T13:00:03
Essential tremors, uncontrollable shaking of the hands, arms, and other parts of the body, have been traditionally treated through drugs or surgery. Cala Health is providing a new option to patient...
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Shaping the Emerging Bioeconomy from 2019-11-07T07:03:33
The ability to engineer biological systems to replace chemical processes is making the promise of the emerging bioeconomy a reality. Some of the leading industry players, though, see a growing need...
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A Belief that Early Interventions Will Be the Key to Treating Alzheimer’s Disease from 2019-10-31T14:00:02
Efforts to develop effective therapies to treat Alzheimer’s disease have been stymied by a long history of clinical failures. Those disappointments have included two, late-stage failures of AC Immu...
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Transforming the Study of Microbes with High-Throughput Technology from 2019-10-24T14:00:12
The study of microbes and their interactions is changing our understanding of biology, but only a small fraction of microbial species have been cultured. One of the challenges researchers have face...
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Using RNA Diagnostics to Predict Patient Response to Immunotherapies from 2019-10-17T18:05:59
Cofactor Genomics believes RNA provides a better means than DNA and other biomarkers to diagnose disease, monitor health, and enhance treatment decisions. The company’s Predictive Immune Modeling p...
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How a Clever Business Model May Accelerate the Use of Companion Diagnostics from 2019-10-10T12:00:14
Scientists can understand individual tumors at a molecular basis, but clinician don’t yet routinely profile and treat cancers based on this knowledge. Strata Oncology, with drug developers as its c...
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Building Cell Therapies with Switches to Modulate Their Activity from 2019-10-03T16:57:24
Bellicum Pharmaceuticals is developing cellular immunotherapies that modulate T cell function through controllable molecular switches. The company is developing these immunotherapies to treat a ran...
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Using Synthetic Biology to Build Intelligence into Cell and Gene Therapies from 2019-09-26T16:45:47
Senti Bio is using synthetic biology to build intelligence into cell and gene therapies, altering the way they act depending on the changing biological circumstances they may encounter in the body....
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A Therapeutic Approach Built on Protein Degradation from 2019-09-19T11:00:16
Nurix Therapeutics is harnessing the body’s natural process for controlling protein levels to target and degrade proteins that drive cancer and other diseases. Its small molecule therapies control ...
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Harnessing AI to Improve Sales and Marketing Decision-Making from 2019-09-12T15:31:35
The biopharmaceutical industry has been embracing artificial intelligence as a way to address complex issues of drug design and development, but Aktana is betting that such big data analysis can im...
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A Doctor's Quest to Cure His Own Rare Disease from 2019-09-11T17:09:41
When David Fajgenbaum was in medical school, he became stricken with a rare autoimmune disease that nearly killed him. Though he recovered, he would suffer recurring, life-threatening flares only t...
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Athersys Advances Off-the-Shelf Stem Cell Therapy for Stroke from 2019-09-05T01:36:52
Among the many challenges to developing stem cell therapies is the need to match donors to recipients and the risk of graft vs. host disease that requires the use of immunosuppressants. Athersys ha...
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Enlisting the Innate Immune System to Fight Cancer and other Diseases from 2019-08-29T04:11:02
Immunotherapies have mostly sought to harness the adaptive immune system, but Silverback Therapeutics believes its technology platform will allow it to enlist the innate immune system in the fight ...
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Using AI to Improve Clinical Development from 2019-08-22T17:23:12
Artificial intelligence is all the rage in drug discovery today, but there are efforts to apply to technology to other aspects of the drug development continuum to improve decision making and incre...
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Addressing the Challenge of Making Antibody-Drug Conjugates from 2019-08-15T02:44:24
Antibody-drug conjugates marry the precise targeting of an antibody to a cytotoxic payload. That has the potential to provide a powerful treatment approach to a variety of cancers with less toxicit...
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Targeting Regulators of Genes to Treat Cancer from 2019-08-08T18:22:40
While much of the focus of drug developers looking to act on the genetic mechanisms underlying diseases has focused on the genes that code for proteins, Syros Pharmaceuticals is looking to the regu...
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Harnessing the Immune System to Diagnose and Treat Cancer from 2019-08-01T15:57:55
Anixa Biosciences is harnessing the immune system to both diagnose and treat cancer. It recently announced a licensing agreement with the Cleveland clinic for a novel breast cancer vaccine that is ...
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Using Synthetic Biology to Produce Cannabinoids from 2019-07-25T17:40:53
There’s growing interest in cannabinoids for their therapeutic potential in a range of conditions, but one challenge therapeutic developers face is a reliable and consistent supply. Teewinot Life S...
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EpicentRx Hopes Rocket-Fuel-Derived Drug Will Propel It from 2019-07-18T18:42:48
Much has been made about a cancer moonshot, but in the world of oncology, rocket fuel is rarely a topic of conversation except maybe as a metaphor. EpicentRx, though, is looking to rocket fuel as a...
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Using Fruit Flies to Personalize Cancer Therapies from 2019-07-11T17:53:18
The complexity of individual tumors creates a challenge for physicians to determine the optimal treatment for any given patient. This complexity may also require a combination of therapies to targe...
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Bridging the Gap Between Data and Knowledge with AI from 2019-07-04T19:04:08
As biomedical data proliferates and the life sciences becomes more closely integrated with data science, the ability for researchers to access, use, and learn from the growing universe of informati...
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How Virtual Reality May Change the Way Researchers Discover and Develop Drugs from 2019-06-27T19:22:52
The convergence of information technology with the life sciences is opening up new ways of approaching the challenges of drug discovery and development. While much has been made about approaches th...
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Addressing the Challenges of Drug Development with a New Market from 2019-06-20T17:27:01
The high cost of developing therapies impedes the pharmaceutical industry’s ability to bring innovative products to market, but also leaves potentially valuable discoveries languishing on universit...
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Addressing the Challenge of Producing Stem Cell Therapies with Consistency at Scale from 2019-06-13T21:05:50
Mesenchymal stem cells may be a powerful way to treat a range of medical conditions but realizing the therapeutic potential of these cells has been hampered in part by the challenges of manufacturi...
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Ensuring a Placebo Response Doesn’t Derail a Clinical Trial from 2019-06-06T17:26
The placebo response in clinical trials can derail a promising experimental therapy that might benefit patients. In cases where trials rely on subjective endpoints or patient-reported outcomes, the...
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Using AI to Find New Uses for Validated Drugs from 2019-05-30T22:00:49
Artificial intelligence is being embraced the pharmaceutical industry as a way to reduce the time and cost of drug development. BioXcel Therapeutics is using AI to leverage as a means to identify n...
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Using Digital Health to Change Our Understanding of What Drives Disease from 2019-05-23T21:57:06
The ability to capture and parse data in real-time and at a vast scale is transforming our approach to biomedical research and has the potential to change the way we think about the causes of disea...
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Cidara Advances Antiviral Conjugate to Treat and Prevent Flu from 2019-05-16T19:19:41
Cidara Therapeutics is developing new anti-infectives using its Cloudbreak platform to develop antiviral conjugates that both directly kill pathogens and also enlist a patient’s immune cells to att...
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Building a Drug Empire on Undervalued Assets from 2019-05-09T12:00:19
Roivant Sciences doesn’t fit easily into conceptions of drug companies, venture capital firms, or accelerators. It is building highly-focused drug development companies around promising undervalued...
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Bringing Precision Medicine to Autoimmune Disease from 2019-05-02T15:00:09
Advances in precision medicine have helped to reshape the cancer landscape with the development of diagnostics to determine whether a patient may benefit from a specific drug. Little progress, thou...
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Fighting Drug-Resistant Fungal Infections from 2019-04-25T16:36:54
Concerns about the threat posed by the growth of drug-resistant pathogens has often focused on the need to reinvigorate our arsenal of antibiotics, but health authorities are paying new attention t...
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Accelerating Early-Stage Biotechs from 2019-04-18T19:12:39
The effort to cost-effectively accelerate the development of new therapies has led to the rise of new business models that seek to provide expertise, capital, and access to professional networks th...
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Agenus Advances Broad Immuno-Oncology Pipeline from 2019-04-11T18:09:06
Agenus is an immuno-oncology company with a long history and a broad portfolio. To help fund its pipeline, it entered into a significant alliance with Gilead Sciences in December 2018 and has used ...
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Targeting the Right Proteins to Treat Neurological Diseases from 2019-04-04T17:45:14
The recent late-stage failure of another high-profile Alzheimer’s disease drug candidate is a reminder of the challenges of developing drugs for neurological diseases. These challenges are driven b...
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A Treat Locally, Act Globally Strategy for Treating Cancer from 2019-03-28T17:48:51
Intensity Therapeutics argues that cancer is both a micro and macro disease. Therapies need to act at the site of tumors, but they also need to treat the systemic effects of the disease that result...
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Squeezing New Possibilities into Cell Therapies from 2019-03-21T17:56:48
SQZ Biotech believes its platform technology can enable the engineering of virtually any function into any cell type allow for a new world of cell therapies to revolutionize the treatment of diseas...
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Industry Calls for New Incentives to Spur Development of New Antibiotics from 2019-03-14T05:22:05
As concerns grow about the rise of antibiotic resistant bugs, the ability to combat them is being undermined by the economics of antibiotic drug development. Many large pharmaceutical companies ste...
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Company Seeks to Prove Marine-Derived Alzheimer's Drug Is No Fish Story from 2019-03-07T19:45:37
Neurotrope is developing its experimental therapy bryostatin as a potential treatment for Alzheimer’s disease and other neurodegenerative conditions. The company believes the drug has multiple mech...
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Targeting the Plasma Proteome to Address Diseases of Aging from 2019-02-28T22:54:53
As people age, their bodies lose the ability to regenerate as well as they were able to when they were younger. Alkahest believes this is tied to changes in the mix of proteins that are present in ...
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Teaching Scientists to Be Effective Communicators from 2019-02-21T17:52:51
There was a time when scientists could spend their careers talking only to other scientists about their work, but that’s changed. Whether it’s the current funding climate, the need to understand co...
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Designing Small-Molecule, Immuno-Oncology Drugs That Act Like Biologics from 2019-02-14T06:21:13
Kleo Pharmaceuticals is a developing next-generation immuno-oncology drugs that are small-molecule compounds designed to act like biologics. Kleo’s compounds activate patients’ immune systems to ta...
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Biohacking for the Masses from 2019-02-07T19:48:22
Josiah Zayner calls himself a biohacker. He’s got a Ph.D. in molecular biophysics from the University of Chicago and worked as a fellow in NASAs synthetic biology program. But it is Zayner’s evange...
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A Hearts and Minds Strategy for Cardiovascular Disease from 2019-01-31T18:13:12
One-third of adults suffer from high blood pressure and 9.4 million people a year will die from complications relating to the condition. In fact, cardiovascular disease remains the leading cause of...
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A Drug Hunter Finds Greater Freedom at a Nonprofit Institute from 2019-01-24T19:42:46
Atrial fibrillation, a condition characterized by an irregular and rapid heartbeat, affects up to 6.1 million Americans and can cause strokes. It is not well addressed by current medical approaches...
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Attacking IBD Through a Novel Pathway from 2019-01-17T19:46:56
Current therapies for autoimmune diseases represent a $100 billion market, but available drugs often provide limited benefits to patients or cause problematic side effects. Landos Biopharma is targ...
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Writing the Future of Drug Research with Bioink from 2019-01-10T17:48:17
The ability to print human tissue is changing the way drug research is conducted today and opens the possibility of one-day printing replacement organs with the technology. CellInk saw an opportuni...
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An Effort to Develop Safer and More Effective Immunotherapies from 2019-01-03T22:18:47
Bing Wang trained as an electrical engineer, but his experience as a cancer survivor led him into the world of healthcare investment banking and then to his current role as CEO of the cancer therap...
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The Year in Biotech and What to Watch in 2019 from 2018-12-27T19:00:34
As the year draws to a close, we continue what’s become an annual tradition and look back on the year in biotech and ahead to the J.P. Morgan Healthcare Conference and beyond with Adam Feuerstein, ...
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Why One Investor Is Betting on Platform Technologies to Change the World from 2018-12-20T18:58:07
The ability to manipulate and understand biology at the molecular level coupled with powerful computing capabilities is opening up new possibilities to harness technology to improve human health. T...
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Price Transparency and a Healthcare Policy Analyst's Brush with the Healthcare System from 2018-12-13T12:00:15
Paul Keckley is a long-time healthcare policy analyst whose both worked within hospital systems and advised major healthcare organizations, but when he recently collapsed on a golf course due to se...
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How a Leading Health Sciences University is Working to Address Homelessness from 2018-12-06T18:16:11
Matt State is known for his work trying to understand the biology underlying psychiatric illnesses, but as the chairman of the University of California, San Francisco’s Department of Psychiatry, pa...
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Gecko Looks to Broad Applications in Tissue Reconstruction from 2018-11-29T19:15:10
Gecko Biomedical’s first product Setalum is a sealant that prevents bleeding after the use of sutures to repair blood vessels, but the polymers underlying the product represent a platform technolog...
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The Search for Mediators of Aging from 2018-11-22T00:16:12
In 1988, researchers showed that they could extend the lifespan of worms by manipulating the genetics of these model organisms. The implications that the normal aging process could be altered ignit...
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Using Drug Delivery Technology to Improve ADHD Therapies from 2018-11-15T22:10:44
People with attention-deficit/hyperactivity disorder who use stimulants to treat the condition often face afternoon crashes and require the use of booster doses. Cingulate Therapeutics is using its...
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How One Company Is Targeting a Growing Opportunity in Women's Reproductive Health from 2018-11-08T16:00:08
Problems of women’s reproductive health represent a growing worldwide concern, but it remains an area of unmet medical needs. ObsEva is advancing a late-stage clinical pipeline with development pro...
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Why an HIV Drug in Development Could Change How Cancer Is Treated from 2018-11-01T15:00:03
CytoDyn’s lead candidate for HIV is part of a new class of therapies that work by protecting healthy cells by blocking viral infection. But the receptor that the drug targets also plays a role in c...
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How the Rise of the Patient-Consumer Is Changing Clinical Trials from 2018-10-25T15:00:03
The rise of the Internet, social media, and communications technology has transformed consumer behavior. Consumers today are better informed, expect a high-level of engagement, and a modern service...
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Bringing Real-World Monitoring to Autoimmune Disease from 2018-10-18T15:00:09
DxTerity is a genomics company that’s providing real-world monitoring of patients with autoimmune disease with from-home RNA testing to improving the management of these conditions. The company’s t...
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Using Real-World Evidence to Improve Drug Development from 2018-10-11T15:13:05
The availability of a growing body of real-world evidence has regulators considering how clinical trials using disparate sources of data might work. Many see harnessing such information as a way to...
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Enlisting Immunotherapies in the Fight Against Infectious Diseases from 2018-10-04T15:00:09
Immunotherapies are changing the way physicians treat various cancers, enabling and enlisting a patient’s immune system in the fight against a deadly disease. But this approach has largely been lim...
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Tackling the Problem of Resistance in Chemotherapy from 2018-09-27T15:34:20
Nucleoside analogs are a widely used class of chemotherapeutic agents, but the ability of cancer cells to evade them and develop resistance limits their benefits and increases their side effects. N...
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Engineering Bacteria for Therapeutic Benefit from 2018-09-20T18:31:10
Synlogic is using synthetic biology to engineer probiotic bacteria to deliver therapeutic benefit. By targeting the microbiome of the gut, the company believes it can produce systemic effects to tr...
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The Promise of Organ-on-a-Chip Technology to Improve Drug Development from 2018-09-13T21:09:22
One way to improve drug discovery and development is to work with more accurate models of human biology and human disease. Organ-on-a-chip technology that provides three-dimensional cell models in ...
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Harnessing AI to Fight Diseases of Aging from 2018-09-06T16:24:15
Insilico Medicine is working to harness artificial intelligence to address diseases of aging and in the process reinvent the way new drugs are discovered and developed. Its AI platform is integrate...
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Transforming Clinical Trials with Digital Health Technologies from 2018-08-30T17:26:37
Digital health technologies are providing new ways of monitoring patients and delivering care. In the realm of clinical trials, they provide a way to remove geographic barriers to patient participa...
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Why Foresite Capital is Betting Big on the Convergence of AI and Biotech from 2018-08-23T18:43:19
The convergence of artificial intelligence and the life sciences is promising to revolutionize the entire healthcare continuum including the way drugs are discovered, how clinical trials are conduc...
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Predicting the Unpredictable Off-Target Activities of Drugs from 2018-08-09T19:35:22
One of the reasons for the high cost of drug development is that most drugs fail in clinical development. Even though preclinical testing can provide a good insight into whether a drug hits an inte...
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Why Clinics Providing Stem Cell Therapies not Approved by the FDA Are Creating Growing Concern from 2018-08-02T18:08:42
Stem cell therapies represent an area of great promise for treating intractable eye diseases, but there’s growing concern about clinics that promote costly stem cell treatments that have not been a...
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Making Biomedical Discoveries Sooner from 2018-07-26T18:38:28
Say “Oklahoma” and someone might think of wheat fields, natural gas, or the wind sweepin' down the plain. Cutting edge biomedical research, though, is probably not the first thing that comes to min...
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Reinventing Drug Discovery with AI from 2018-07-19T20:19:30
Recursion Pharmaceuticals is reinventing the drug discovery process by turning biology into a data science problem. The company has set an audacious goal for itself of developing 100 drugs in 10 ye...
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Carrying Therapeutic Payloads Across the Blood-Brain Barrier from 2018-07-12T17:56:16
The blood-brain barrier provides essential protection against pathogens while allowing needed oxygen and nutrients to pass. However, one challenge it presents is getting therapeutics delivered to t...
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Harnessing Bacteria to Improve Skin Health from 2018-07-05T17:27:53
There’s been much made of the potential of the microbiome to address disease and promote wellness. While much of the therapeutic efforts in this area have focused on the microbiome of the gut, Azit...
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How One Accelerator Tries to Give Early-Stage Drug Developers an Edge from 2018-06-28T17:51:20
Incubators and accelerators come in many flavors. Mass Innovation Labs is seeking to distinguish itself with its approach to providing research scientists with infrastructure comparable to what a d...
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Making Synthetic Biology a Commercial Reality from 2018-06-21T15:33:16
Intrexon has been at the forefront of efforts to harness biotechnology to address significant issues in health, energy, food, and environmental sustainability. The company is applying synthetic bio...
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Why Behavioral Economics May Turn Irrational Patients Rational from 2018-06-14T16:08:15
The field of behavioral economics is premised on the fact that people are irrational. By harnessing tools, such as incentives, healthcare providers and drugmakers are trying to change patient behav...
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Pushing the Frontiers of Longevity from 2018-06-07T16:59:16
Dmitry Kaminskiy does not have a lot of kind words for aging. In fact, the general partner at Deep Knowledge Ventures and managing trustee of the Biogerontology Research Foundation has called it th...
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Is Hearing Loss a Necessary Price for Children to Pay for Life-Saving Chemotherapies from 2018-05-31T20:26:30
Children undergoing chemotherapy often face permanent hearing loss as a result of the toxicity of these treatments. The Children’s Cause for Cancer Advocacy is organizing a Patient Focused Drug Dev...
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Why Diagnostics May Be Critical to Reshaping Alzheimer's Drug Development from 2018-05-24T21:42:46
Alzheimer’s disease has been a costly and elusive area for drug developers. Despite many promising results in early-stage trials, drug companies have seen millions of dollars of R&D investment end ...
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Why the Diversity of Genomic Data Matters from 2018-05-17T20:28:56
The lack of diversity in genomic data has been an issue of growing concern. It threatens to limit the benefits from the massive investment that has been made to date to transform biomedical researc...
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Why Biomarkers May Be the Key to Immuno-Oncology Success from 2018-05-10T18:05:47
Developers of cancer immunotherapies are in a race to find combinations that can distinguish their products for specific indications. Biomarkers, which have played an essential role in the developm...
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Seeing Virtue in Patients from 2018-05-03T18:33:24
As the value of the patient perspective gains greater recognition throughout the healthcare continuum, Wego Health is seeking to both tap and provide that perspective to guide a range of clients wi...
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When Science Becomes a Cause from 2018-04-26T17:28:55
It seems to be strange times when people feel the need to take to the streets to voice their support for science, but that’s what happened earlier this month as the second annual March for Science ...
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The Pursuit of Healthier, Safer, and More Humane Meat from 2018-04-19T16:14:37
The global demand for meat is rising as is concerns about the health dangers, environmental toll, and animal welfare issues related to the way we produce meat today. The Good Food Institute is a no...
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A Hidden Killer and Why Patients Face Barriers to Accessing Promising New Drugs for It from 2018-04-12T18:51:33
Familial hypercholesterolemia, or FH, is an inherited disorder that leads to premature cardiovascular disease. It can lead to heart attacks, strokes, and the narrowing of heart valves. In people wi...
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Targeting the Regulators of Genes to Treat Disease from 2018-04-06T08:37:43
While most drug developers have sought to target aberrant genes or the proteins driving diseases, Syros Pharmaceuticals has developed a proprietary platform that targets the regulatory region of DN...
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Price-Fixing Case Against Generic Drugmakers Widens from 2018-03-29T19:25:53
A sharp spike in generic drug prices that triggered an investigation in Connecticut continues to deepen. The antitrust case that alleges price-fixing and widespread collusion between generic drug c...
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Outcomes Erode for Newborns and Mothers in Rural America as Hospitals Lose Obstectric Services from 2018-03-22T20:02:23
Rural counties in the United States have seen a steady loss of hospital-based obstetric services. A new study published in JAMA that looked at nearly 5 million births in almost 1,100 rural U.S. cou...
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Why Drug Companies May Soon Become Health Technology Companies from 2018-03-15T18:50:04
The convergence of technology and life sciences, changing consumer behavior, and increasing pricing pressures on drug and device makers are forcing these companies to rethink business models and ho...
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After Facing Death, Former HR Director Helps Others Get a New Perspective on Life from 2018-03-08T21:09:05
Matthew Levy worked in the biopharmaceutical industry in human resources when he was confronted with a life-changing event. A doctor told him he had advanced cancer and just 90 days to live. An agg...
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Putting Physics to Work in the Fight Against Cancer from 2018-03-01T22:43:37
Despite the often remarkable advances in cancer therapies, radiation is still widely used to treat a variety of cancers. Nanobiotix believes it can make radiation therapy more effective by injectin...
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Why Aging Might Best Be Thought of as a Disease from 2018-02-22T17:28:24
As medical advances have helped extend lifespans, older people still experience a decline in quality of life in their later years as a result of diseases associated with aging. This can cause a los...
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Looking for a Better Alternative to Chemotherapy for AL Amyloidosis from 2018-02-15T23:03:18
Caelum Biosciences, a Fortress Biotech company, is a clinical-stage biotech developing treatments for rare and life-threatening diseases. It’s lead therapeutic in development is a novel antibody to...
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A University Spin-Out that Incubates University Spin Outs from 2018-02-08T20:21:48
Incubators create success stories, but usually aren’t thought of as success stories themselves. The newly renamed MBC Biolabs, which started with humble beginnings in a utility closet as the first ...
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Understanding the Challenges and Opportunities of Patient-Centric Outcomes from 2018-02-02T19:47:39
Across the continuum of drug discovery, development, and delivery there’s a growing effort to incorporate the patient perspective into the process. Last year FasterCures, the nonprofit focused on a...
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How CellMax Hopes to Change the Diagnosis Cancer with Inexpensive Liquid Biopsy from 2018-01-25T19:26:56
CellMax Life believes it can transform cancer diagnostics with its affordable non-invasive tests for early cancer detection. The company says with its platform it has been able to overcome the chal...
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How Surveillance and Data Are Bringing Precision to the Treatment of Prostate Cancer from 2018-01-18T20:40:57
The development of a biomarker to identify people with prostate cancer increased the diagnosis of the disease, but did little to suggest the appropriate course of treatment for individual patients....
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Why Life Sciences M&A Should Heat up This Year from 2018-01-11T18:56:04
A surge in merger and acquisition activity in the life sciences is expected this year, according to a new report from EY. The company annual M&A Firepower Report says increased competition, new sou...
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The Outlook for Biotech in 2018 from 2018-01-04T20:47:20
We conclude our biotech review-preview series with our final installment this week as we take a look at the year ahead as the industry readies for the JPMorgan Healthcare Conference. We spoke to Jo...
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The Year in Biotech and What to Watch in 2018 from 2017-12-28T19:04:23
In the second installment of our three-part review-preview series of podcasts, we continue an annual tradition by sitting down with Adam Feuerstein, senior biotech writer for STAT, to discuss the y...
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The Year in Immuno-Oncology and What to Watch in 2018 from 2017-12-21T18:49:01
It’s that time of year when we begin to look back and think ahead. Starting with this week’s interview, we begin a three-part review-preview series to discuss the year in biotech and what to look f...
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What the Approval of the First Digital Pill Means for the Future of Healthcare from 2017-12-14T21:00:45
Last month Otsuka Pharmaceutical and Proteus Digital Health won U.S. Food and Drug Administration approval for what’s being hailed as the first digital pill. Abilify Mycite, a drug-device combinati...
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Why Public Health Systems Need to Be Better Prepared for Extreme Weather Events from 2017-12-07T22:32:28
Climate change and the increasing frequency and intensity of extreme weather events carry a toll on human health. Not only do floods, hurricanes, and other similar phenomenon cause death and injury...
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Former CDC Director Takes on World's Leading Cause of Death from 2017-11-30T20:03:12
Tom Frieden, after eights years of running the U.S. Centers for Disease Control and Prevention, is turning his sights to global health. Frieden has set a goal of saving 100 million lives from cardi...
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How a Public-Private Consortium Is Revolutionizing Cancer Drug Discovery from 2017-11-23T20:03:31
A public-private consortium is seeking to cut the time it takes to discover and advance new cancer therapies to the clinic to one year from the six years it takes on average today. Accelerating The...
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How Faulty Thinking Can Derail Life Sciences M&A Deals from 2017-11-16T18:33:20
Merger and acquisitions may be a path to creating value for life science companies, but talks can breakdown because of flaws in management thinking that skew their sense of the value of their compa...
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Targeting Drug-Resistant Bacteria with an Ancient Enemy from 2017-11-09T20:44:03
The growing problem of bacterial resistance to antibiotics represents a significant public health threat. That’s been made worse by the dearth of new therapies that have come to market. AmpliPhi Bi...
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A Bioelectronic Approach to Treating Autoimmune Diseases from 2017-11-02T19:29:24
Bioelectronic therapies are being developed to treat a number of conditions that currently can only be addressed using pharmaceutical interventions. Thync, a bioelectronics company, believes its te...
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Harnessing Patient Data to Improve Drug Development Efficiency from 2017-10-26T16:53:40
Despite the growing volume of electronic health records, they have so far left the recruitment of clinical trial patients, clinical trial designs, and site selection largely unchanged. The result i...
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How Colorifix Is Trying to Turn the Textile Industry Green from 2017-10-19T19:55:29
Synthetic biology is promising to harness living organisms to replace industrial processes that rely on toxic chemicals, consume large amounts of energy and water, and leave environmental degradati...
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Targeting Patients as Sick as Dogs from 2017-10-12T17:09:30
Kindred Biosciences is looking to leverage the billions of dollars that others have invested in approved drugs by modifying, improving, and repurposing them for the animal market. The company belie...
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A Strategic Investor's View of the Biotech Investment Landscape from 2017-10-05T17:16:43
When the BIO Investor Forum convenes in San Francisco October 17 and 18, a key point of discussion will be the availability of funding for emerging life sciences companies. One of the panelist addr...
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Bringing Gender Diversity into Biotech Boardrooms from 2017-09-28T19:32:41
In April 2016, the consulting firm LifeSci Advisors adopted a comprehensive action plan to advance gender diversity in the life sciences industry. It has partnered with Women in Bio and Girls Inc. ...
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Why the FDA May Need to Rethink Its Approach to Gene and Cell Therapy from 2017-09-21T18:08:50
Regenerative medicine is rapidly moving from the lab to the clinic, but as life-saving therapies advance to the marketplace, there are questions about whether the U.S. Food and Drug Administration ...
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VBL Targets Brain and other Cancers with Novel Immunotherapy from 2017-09-14T14:01:29
Glioblastoma is a devastating and fatal brain cancer that progresses rapidly. Median time from diagnosis to death is 12 to 15 months. In recurrent cases, treatment consists of both symptomatic and ...
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What Will It Take to Transform Healthcare to a System Focused on Prediction and Prevention from 2017-09-07T16:03:55
The promise of precision health is to transform a healthcare system that is today based on treating sickness to harnessing a range of technologies to predict and prevent illness. Health 2.0’s Techn...
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Can a Direct Pitch to Patients Drive a Home Run for Obesity Drug from 2017-08-31T18:00:09
Winning regulatory approval for a drug to treat obesity would seem like a great accomplishment, but for Orexigen Therapeutics, that’s when the hard work began. After its marketing partner Takeda en...
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Why Companies Across Industries Need to Develop a Bio Strategy from 2017-08-24T16:29:50
Though breakthroughs in the ability to read, write, and edit DNA have broad implications for healthcare, they are also fueling a far-reaching transformation of industries and laying the foundation ...
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Economist Argues Maximizing Shareholder Value Hurts Drug Innovation from 2017-08-17T16:20:34
The pharmaceutical industry has long argued that high drug prices are necessary to incentivize investment in and fund high-risk research and development of innovative new therapies. In a working pa...
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Partnership Drives Development of Antibiotic to Combat Resistant Gonorrhea from 2017-08-10T16:21:16
Gonorrhea is a common sexually-transmitted infection, but the growth of an antibiotic-resistant strain of the disease is creating what the U.S. Centers for Disease Control and Prevention has called...
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CIRM-Funded Pipeline of Regenerative Therapies Advances from 2017-08-03T02:55:40
A number of clinical successes and the U.S. Food and Drug Administration’s granting of designations that provide accelerated pathways to experimental therapies speaks to the progress of research fu...
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Technology Allows Drugmakers to Tag and Authenticate Individual Pills from 2017-07-27T16:06:56
The problem of counterfeit and falsified medicines is not just an economic problem for the pharmaceutical industry, but also a threat to public health. TruTag Technologies is seeking to address the...
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Harnessing Mosquitoes to Fight the Spread of Infectious Disease from 2017-07-20T19:22:44
Mosquitoes are more than just pesky. Certain types of insect serve as efficient vectors for infectious diseases that pose great harm to humans. Oxitec, a subsidiary of Intrexon, has developed a gen...
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Biotech Industry Moves Towards a Patent Cliff from 2017-07-13T16:58:08
Scrutiny of drug prices around the globe is expected to exert growing pressure on the biopharmaceutical sector. EvaluatePharma, in its recently issued World Preview 2017, Outlook to 2022 says that ...
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PvP Takes a Unique Approach to Treating an Autoimmune Disease from 2017-07-06T08:57:27
Celiac disease, an autoimmune disorder that has helped to drive the gluten-free food craze, can carry serious complications. There’s no treatment for the disease, which afflicts an estimated 2.4 mi...
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Uncertainty Hangs over the Biotech Sector from 2017-06-29T13:25:39
The lack of clarity over healthcare reform, changes to tax policy, and concerns about new pricing pressures are creating uncertainty over the future health of the biotech industry. EY, in its just ...
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What Others Can Learn from COI's Approach to Cost-Efficient Drug Development from 2017-06-22T03:18:11
The high cost of drug development, the challenge of translational research, and continuing concerns with R&D efficiency has had entrepreneurs, investors, and drugmakers open to experimenting with n...
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Dyadic Seek to Bring Disruptive Technology to Biomanufacturing from 2017-06-15T16:27:36
The production of biologics is costly and takes time. Dyadic International has developed a proprietary manufacturing process that replaces the use of Chinese hamster ovary cells, long used to produ...
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Enlisting the Immune System in the Battle Against Alzheimer's from 2017-06-08T16:14:10
Alzheimer’s disease is the sixth leading cause of death and it continues to rise. Today it is costing the U.S. healthcare system $200 billion a year and there are no therapies that prevent, halt, o...
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Overcoming the Delivery Challenges of Gene Therapy from 2017-06-01T15:55:21
Gene therapy represents an expanding area of potential to correct and modulate the activities of genes driving diseases. One of the major challenges these groundbreaking technologies face, though, ...
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Brexit Sparks Battle to House the EMA from 2017-05-25T16:54:53
Brexit, the United Kingdom’s plan to withdraw from the European Union, carries a long list of unintended consequences, one of which is the relocation of the European Medicines Agency. As many as 20...
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New Safety Concerns Identified After FDA Approval of One in Three Drugs from 2017-05-18T16:12:21
Nearly one in three drugs has a postmarket safety event, according to a study published earlier this month in JAMA. The study looked at 222 novel therapies approved between 2001 and 2010. We spoke ...
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Why Climate Change Is a Public Health Concern from 2017-05-10T19:03:10
Climate change is not often viewed as a public health threat, but it can have unexpected consequences on the spread of infectious diseases. As changing temperatures make new areas more hospitable t...
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Reflections on the Progress and Promise of Personalzied Medicines from 2017-05-04T19:26:45
Ten years ago, a group of San Francisco State University alumni working at Genentech got together with the Michael Goldman, the university’s chairman of the biology department, to establish the sch...
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Curing Cancer with Math from 2017-04-27T16:39:44
The promise of precision medicine to provide more effective and safer cancer therapies that target the genetics driving each patient’s disease has been hindered by the lack of understanding of the ...
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How Healthcare Consumer Find and Use Price Information from 2017-04-20T17:21:05
For anyone who has ever sought to find the price of healthcare services before obtaining them it will come as little surprise that information is not readily available. A recent study from Public A...
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Why Infectious Disease Represents a National Security Threat from 2017-04-13T18:36:20
As the Trump Administration calls for significant increases in military spending, it is also seeking steep cuts to the National Institutes of Health, the Centers for Disease Control and Prevention ...
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Recent Mumps Outbreaks Raise Question If New Vaccine Is Needed from 2017-04-06T17:09:02
Recent mumps outbreaks are raising questions about strategies to combat the spread of the virus. One issue of concern is that the current vaccine is designed to protect against a different strain o...
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Proposed Legislation Would Weaken Genetic Privacy Protections from 2017-03-30T21:08:48
The landmark legislation known as the Genetic Information Nondiscrimination Act of 2008, or GINA, anticipated growing concerns about genetic privacy, although it left much work undone. Now, though,...
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How Biomarkers Can Alter the View of and Approach to Alzheimer's Disease from 2017-03-23T05:30:43
By the time signs of Alzheimer’s disease manifests in the form of memory problems, behaviorial changes, or loss of executive function, years of irreversible damage to the brain has already occurred...
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The Fight for Personalized Medicine Wages on Many Fronts from 2017-03-16T16:34:25
The Personalized Medicine Coalition’s recently issued its 2017 report on the opportunities and challenges for the industry. Chris Wells, communications director for the organization, will be kickin...
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Big Pharma and the Growth and Outlook for Orphan Drugs from 2017-03-09T17:59:35
Orphan drugs, therapeutics that target small patient populations, have become an enticing area for Big Pharma as companies are attracted to the premium prices, lower development costs, and faster p...
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What the Recent Patent Ruling Means for the Future of Gene-Editing Technology from 2017-03-02T17:14:07
The Broad Institute has emerged victorious in a battle with researchers at the University of California, Berkeley over patents covering breakthrough gene-editing technology that allows scientists t...
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Weighing What Limits Should Be Put on Gene Editing from 2017-02-23T17:15:27
Earlier this month the National Academy of Sciences and the National Academy of Medicine issued a report that considered the scientific, ethical, and governance issues surrounding human genome edit...
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Enlisting the Immune System in the War on Cancer from 2017-02-16T17:31:54
The emergence of cancer immunotherapies, drugs that activate and enlist the immune system to fight cancer, has emerged as a promising approach to combat the disease in its many forms. Lawrence Fong...
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Why Scientists Must Also Be Advocates from 2017-02-09T18:37:45
The start of Trump administration, a new cabinet, and a new Congress are raising concerns within the scientific community about how the changes in Washington will affect the health of science and i...
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Sernova Eyes Range of Disease for Implantable Cell Technology from 2017-02-02T17:28:41
For a number of diseases that require chronic administration of a substance naturally produced by the body, patients may have to rely on regular injections or infusions. Sernova is working to free ...
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Stratus Wants to Demonstrate Its Telehealth Fluency from 2017-01-26T20:12:30
Telehealth, which encompasses an array of technologies to deliver healthcare, is a rapidly growing area. Stratus Video, a language services company, is making a push into telehealth where it sees a...
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Regeneron Embraces Genetics as Fundamental to Drug Development from 2017-01-19T19:04:27
Drug discovery and development is a slow and costly process, but the Regeneron Genetics Center represents a drugmakers’ bet that harnessing large amounts of genetic data can point the way to better...
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Despite FDA Setback, KemPharm Advancing Prodrug Pipeline from 2017-01-12T17:35:50
Last year, KemPharm was on its way to winning an FDA approval for its opioid Apadaz designed to deter users from snorting, injecting, or otherwise abusing it. But the regulatory agency stymied the ...
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Using digital technologies to improve diagnosis and treatment of mental health patients from 2017-01-05T17:12:20
In the realm of mental health, a lack of biologic measures for diagnosing and treating patients has at times made this an area where doctor’s subjective decisions can play a disproportionate role. ...
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Biotech in 2016 and the Year Ahead with TheStreet's Adam Feuerstein from 2016-12-29T18:42:33
With 2016 drawing to a close and the biotech industry gearing up for the annual JPMorgan Healthcare Conference in San Francisco, we continued our holiday tradition of checking in with Adam Feuerste...
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Harnessing Gut Bacteria to Treat Disease from 2016-12-22T17:06:03
While there has been much buzz in the industry over the potential for harnessing the microbiome and using it as a way to treat disease, it remains early days for the therapeutic pipeline. Rebiotix,...
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A Look at What's Ahead for Biopharma in 2017 from 2016-12-15T16:10:34
Investors bid up biopharmaceutical stocks following the election of Donald Trump as President of the United States. It reflected a belief that a Trump administration will remove the threat of price...
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AMA Wants Docs to Have Seat at mHealth Table from 2016-12-08T16:14:13
The advent of digital health devices and mobile health apps has the potential to improve care, change patient behavior, and permit doctors to intervene early when the health of a patient changes. B...
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Testing of New HIV Vaccine Carries Hopes of a Breakthrough from 2016-12-01T17:19:45
A clinical trial of an experimental vaccine against HIV that just began in South Africa is raising new hopes of making new strides against the disease. The trial follows recent news of tests in ani...
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Centrexion Takes Aim at Pain with Growing Portfolio of Non-Opioid Therapeutics from 2016-11-24T18:37:04
Pain takes both a personal toll on individuals who suffer from it and an economic toll on society more broadly. Though there is a wide range of drugs available to treat pain, it’s a problem that is...
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Bringing Women into Biotech Boardrooms from 2016-11-18T16:53:56
A number of studies have recently called attention to the lack of gender diversity in leadership positions in the life sciences industry. Women in BIO and LifeSci Advisors have taken steps to incre...
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Novartis Deal Validates Perlara's Approach to Rare Disease Drug Discovery from 2016-11-10T16:40:51
Perlara is a drug discovery company focused on using model organisms to find treatments for diseases previously believed to be too rare to cure. Recently Perlara entered into a drug discovery and d...
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Harvesting the Aquatic Microbiome for New Drugs from 2016-11-03T16:27:21
There’s been much buzz about the microbiome, but what that constitutes can mean different things to different people. Biosortia Pharmaceuticals is focusing on the aquatic microbiome as a rich sourc...
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How TwoXAR Is Using Big Data to Accelerate Drug Discovery from 2016-10-27T19:50:41
It can take up to six years to accumulate enough evidence to support advancing an experimental drug into clinical development. twoXAR is working to rapidly accelerate that process through the use o...
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Developer of innovative catheter for cancer drugs turns to crowdfunding from 2016-10-20T17:45:06
Robert Goldman had been a successful Internet age inventor having developed some of the critical technology underlying the way digital music is stored, searched, and purchased online. But when his ...
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Harnessing Real World Samples and Data to Speed Biomedical Research from 2016-10-13T15:58:19
One of the issues researchers face is getting access to needed biospecimens with detailed clinical data that can expand the understanding of a specific disease or treatment. The difficulty in obtai...
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A Rich Pipeline Expected to Drive Industry's Growth from 2016-10-06T01:28:05
Evaluate Pharma, in its latest World Preview report, is projecting solid growth for prescription drug sales through 2022. Driving that growth is both the new products expected to come to market dur...
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Harnessing Biology to Transform the Economy from 2016-09-29T16:34:23
The growing promise to harness biology to address environmental, agricultural, health, and energy needs is fueling a new bioeconomy. The state of engineering biology will be on display at the SynBi...
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How a Predictive Diagnostic Can Reduce Preterm Births from 2016-09-21T18:46:17
About 380,000 infants in the United States—about one in 10— are born prematurely each year. Preterm births, defined as any birth before 37 weeks of pregnancy, is the leading cause of death for infa...
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Building Better Drugs for Psychiatric Disorders by Targeting the Causes from 2016-09-15T16:51:40
The Johns Hopkins University School of Medicine and the Salk Institute for Biological Studies are leading a $15.4 million effort to develop new systems for quickly screening libraries of drugs for ...
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The Role of PBMs in the Controversy over Drug Pricing from 2016-09-08T16:53:44
The recent controversy over Mylan Pharmaceuticals sharp increase to the price of its EpiPen, an emergency injection of epinephrine to treat someone suffering a severe and potentially fatal allergic...
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Why a Rare Genetic Disease May Shed Light on Normal Aging from 2016-09-01T18:48:26
Werner’s and Hutchinson-Gilford Progeria Syndromes are rare, genetic diseases that causes children to appear to suffer from advanced aging at young ages. The syndromes are of particular interest to...
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Battling Zika and Other Diseases Like It from 2016-08-25T18:06:20
Concern about the spread of the Zika virus has sparked efforts to develop therapies and vaccines to counter it. But the outbreak reflects a growing threat from zoonetic diseases, once thought of as...
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Chronicling a Trailblazer of the Genomics Age from 2016-08-18T16:14:13
Lee Hood was a visionary who helped enable the genomics age. Journalist Luke Timmerman, in his newly published biography of Hood, chronicles the scientist career and achievements, as well as the co...
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Great Progress, but Concerns Persist About Cancer Care in America from 2016-08-11T17:34:51
Despite continued scientific and medical progress, the American Society of Clinical Oncology offered a mixed picture in its annual report on The State of Cancer Care in America earlier this year. W...
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Improving Healthcare by Addressing the Most Challenging Patients from 2016-08-04T17:16:23
People with multiple chronic conditions represent about 5 percent of the patient population in the United States, but account for half of the nation’s healthcare spending. In order to improve care ...
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The Case for Chasing Unpopular Indications from 2016-07-28T17:14:19
Neglected diseases and drugs to counter addiction represent unmet medical needs, but they have been areas that pharmaceutical companies have been reluctant to pursue. Savant HWP is in clinical deve...
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Improving Drug Development through Better Use of Biomarkers from 2016-07-21T16:11:55
The use of biomarkers has long held the promise accelerating drug development and producing safer and more targeted drugs to meet the needs of patients. The explosion of genetic, proteomic, and me...
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Measuring the Value of Incubators and Accelerators from 2016-07-14T03:53:25
Incubators and accelerators have been proliferating in California, but little has been done to track their activities and analyze their performance. The California Business Incubation Alliance rece...
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Enlisting New and Old Tools to Combat Antibiotic Resistance from 2016-07-07T16:52:09
The growing problem of antibiotic-resistant bacteria and the evolution of next-generation sequencing technology is giving rise to new approaches to combat what’s become a serious global health thre...
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Advancing Cancer Care with New Diagnostic Tools from 2016-06-30T11:52:47
The ability to find and tumor cells and DNA fragments shed by tumors circulating in the blood has given rise to liquid biopsies. This emerging area of diagnostics promises to improve cancer care, b...
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A Biotech Reinvents Itself and How to Price Drugs from 2016-06-23T03:35:59
KaloBios, a biotech best known for a series of disastrous events including failed clinical trials, a bankruptcy filing, lawsuits, and the arrest of its CEO, is being reborn. In the process, it may ...
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Using Technology to Modernize Preclinical Development from 2016-06-16T16:50:02
Despite a rapid advance of technology there’s been little change in the preclinical drug development process. Vium is hoping to change that by using sensors, automation, and bioinformatics to chang...
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Can the Biotech Industry Stay on Track through Innovative Pricing from 2016-06-08T04:29:59
The biotechnology industry continued to post record numbers, attract significant investment, and won approval for a solid number of new drugs in 2015. Nevertheless, EY in its new Beyond Borders rep...
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Wall Street Turns Its Eyes to ASCO from 2016-06-02T05:00:10
Wall Street’s attention will turn to Chicago as the annual meeting of the American Society of Clinical Oncology gets underway June 3 to June 7. Though this is a scientific conference, it is one clo...
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Understanding the Disease It Never Was on House from 2016-05-26T16:05:25
Lupus is an often misunderstood and misdiagnosed autoimmune disease. While some 1.5 million people—mostly women—have lupus, it can take years for someone with the disease to get a correct diagnosis...
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Why the State of Innovation Is Encouraging from 2016-05-19T17:13:28
Global innovation activity experienced broad gains across industry sectors last year, according to Thompson Reuters newly released 2016 State of Innovation report. We spoke to Anthony Trippe, senio...
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Can Market Forces Fix Drug Pricing from 2016-05-12T13:52:29
The Campaign for Sustainable Rx Pricing, a coalition of healthcare stakeholders, thinks that the rising cost of prescription drugs can be addressed through a series of market-based solutions that w...
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Digital Health Device Seeks to Push Beyond Cannabis to Test Food, Air, and Water from 2016-05-05T16:20:51
The emergence of smartphones at the center of a growing universe of digital health devices is giving rise to new ways to monitor and measure our bodies in real time. MyDx, one of the latest entrant...
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Why the Cancer Moonshot Offers a Chance to Rethink Funding Priorities from 2016-04-28T16:34:21
The Obama Adminstration’s Cancer Moonshot initiative is a boost to cancer researchers, but Bruce Zetter says in order for it be as effective as possible, it must not repeat the same funding priorit...
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Medtronic Advances Toward an Artificial Pancreas from 2016-04-21T19:06:22
For people with type I diabetes, the day-to-day management of the disease can be a full-time job involving the monitoring blood glucose levels and injection of insulin. The medical device giant Med...
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Using Real-Time Data to Detect HIV Outbreaks from 2016-04-14T15:15:53
By using data from routine testing about the genetic evolution of the HIV /AIDS virus in the Canadian province of British Columbia, researchers have shown they are able to identify emerging outbrea...
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Why Pharma Needs to Forge New Drug Pricing Models from 2016-04-07T15:29:03
As pricing pressure grow on the pharmaceutical industry, a recent article in Invivo argues that drugmakers must look to a variety of new pricing models built around collaborations with payers and p...
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Gensight Targets Gene Therapy on Diseases that Blind from 2016-03-31T17:52:19
The France-based biotech Gensight Biologics is developing gene therapy treatments for rare, mitochondrial, and neurodegenerative diseases of the eye. Its lead therapeutic candidate is in late-stage...
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A Vial Problem: How We Waste $3 Billion of Cancer Drugs a Year from 2016-03-24T15:49:42
Nearly $3 billion a year is wasted on cancer drugs because of the way they are packaged, according to a study in BMJ. These expensive drugs that are injected or infused come in fixed size vials and...
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The Havoc-Wreaking Zombies Lurking in Life Sciences Boardrooms from 2016-03-17T03:26:22
The walking dead live, but it's value, not brains, they are eating. So-called zombie funds, life sciences venture capital funds that are fully invested and unable to raise new money, still maintai...
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New FDA Chief Faces Challenges from 2016-03-10T05:26:29
Last month, the Senate confirmed Robert Califf, a cardiologist and clinical researcher from Duke University, as commissioner of the U.S. Food and Drug Administration. Though he was overwhelming con...
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Seeking a Best-in-Class Antibody at Bargain Basement Prices from 2016-03-03T04:15:39
Bird Rock Bio, a small, San Diego-based biotech, is planning to take aim at some of the biggest biologics on the market with an antibody in development to treat rheumatoid arthritis that it says it...
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Pharma Bro, Price Controls, and the Quest to Balance Innovation with Affordability from 2016-02-25T16:47:43
The embattled pharma executive Martin Shkreli, whether intentional or not, has ignited a long smoldering public policy discussion about the pricing of pharmaceuticals. As there are growing calls fo...
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California’s Stem Cell Agency Plots Its Future from 2016-02-18T15:34:23
The California Institute for Regenerative Medicine, California’s voter-established stem cell agency, is thinking about its future. The institute recently issued a strategic plan for the next five y...
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ViaCyte Pursues "Functional Cure" for Type 1 Diabetes from 2016-02-11T14:35:46
About 1.3 million people in the United States have type 1 diabetes, which requires constant monitoring and regular injections of insulin. The autoimmune disease attacks the insulin producing beta c...
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Building a Better Pain Pill from 2016-02-04T16:56:57
Non-steroidal anti-inflammatory drugs are the most widely used medications in the world. They are used to treat pain resulting from diseases such as arthritis, but these drugs can raise blood press...
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Project GENIE Hopes to Make Precision Medicine a Reality from 2016-01-28T16:56:38
The American Association for Cancer Research, with seven leading cancer research centers, has launched Project GENIE to determine how to better tailor treatments to patients’ individual cancers. Th...
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FDA Wants Industry to Guard Against Cybersecurity Risks of Medical Devices from 2016-01-21T21:18:35
As medical device makers are building network connectivity and intelligence into their products, they are adding new vulnerabilities and risks as well. The U.S. Food and Drug Administration has jus...
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Pharma's Leadership Vacuum and Its Price to the Industry from 2016-01-14T23:17:22
The pharmaceutical industry appears to have lost ground in 2015 on the ongoing debate around drug pricing, a problem that Christopher Bowe sees in part as a failure of leadership within the industr...
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Permanent R&D Tax Credit a Boost to Life Sciences from 2016-01-07T20:22:43
As 2015 came to a close, Congress passed a package of tax extenders that among other things expanded the Research and Development Tax Credit and made it permanent. The move represents a big win for...
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Biotech in 2015 and the Year Ahead with TheStreet's Adam Feuerstein from 2015-12-31T00:43:29
The year 2015 was another big one for biotech with record dealmaking, big drug approvals, and solid performance, but it somehow didn’t feel as good as it looks on paper. Pricing concerns that garne...
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Trends Shaping the New Health Economy in 2016 from 2015-12-24T08:31:29
Growing costs pressures, the integration of technology, and the transformation of the patient into a healthcare consumer is giving rise to a new health economy. In its report on the top health indu...
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Declining R&D Productivity Continues to Plague Big Pharma from 2015-12-17T20:31:25
Despite a record number of new drug approvals this year, the return on R&D investment for the largest pharmaceutical companies continues to fall, according to a new report from the Deloitte Centre ...
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Searching for Solutions to Rising Specialty Drug Prices from 2015-12-10T18:37:21
Retail prices for more than 100 widely used specialty drugs rose nearly 11 percent in 2013, according to a new report from AARP Public Policy Institute. The report found that the average annual cos...
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Biohackers Seek a Faster, Cheaper Path to Insulin from 2015-12-03T00:33:29
A team of biohackers is developing the first open source protocol to produce insulin simply and economically. The hope is that their work will serve as the basis for generic production of insulin a...
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A Scorecard to Improve Drugmakers' Transparency from 2015-11-25T19:48:50
A large number of clinical trials underlying the approval of drugs never come into public view. This not only has legal and ethical ramifications, but implications for the healthcare system as a wh...
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Forget the Chemistry Set, Mom, I Want a Bioreactor from 2015-11-19T15:58:53
The power of genetic engineering will soon be available for the home thanks to the Amino One, a piece of hardware about the size of a laptop computer that would allow users to manipulate the DNA of...
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Ensuring Biological Tools Benefit the Environment from 2015-11-13T00:08:22
New gene editing technologies are expanding the ease and power with which scientists can manipulate biological systems with the promising of addressing not only human health issues, but problems th...
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New SEC Rules Open Crowdfunding to the Masses from 2015-11-05T02:24:53
The U.S. Securities and Exchange Commission last week finalized rules on crowdfunding that opens the door for the participation of non-accredited investors. The rules complete a long process for th...
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Harnessing Biology to Address Global Challenges from 2015-10-29T15:49:43
Growing challenges in the areas of health, food, energy, and the environment have increased efforts to harness biology to create sustainable solutions to global problems. With advances in the abili...
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Immunotherapies ETF Lets Biotech Investors Bet on Emerging Sector from 2015-10-22T17:56:49
A new class of immunotherapies is promising to radically alter the treatment of cancers and has generated excitement among investors for their groundbreaking potential. Now the Loncar Cancer Immuno...
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Biotech Investors Turn Their Eyes to Policy Matters from 2015-10-16T16:20:14
Wall Street doesn’t like uncertainty and there are a number of policy issues now brewing that threaten to create some uncertainty for the biotechnology industry. As the BIO Investor Forum kicks off...
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Why the MedTech Industry Should Worry About Future Innovation from 2015-10-08T18:39:16
The medtech industry has enjoyed robust M&A activity, strong financings, and a rise in R&D investments, but other numbers point to troubling developments that threaten the future health and growth ...
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Rare Disease Drug Developer Shows Speed of Business Model from 2015-10-01T17:13:54
Vtesse, a rare disease drug development company, this week announced that it was initiating a late-stage pivotal trial for its lead experimental therapeutic to treat Niemann-Pick Type C1 disease. T...
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Ensuring Value-Based Care Addresses What Matters to Patients from 2015-09-24T14:58:20
The U.S. Department of Health and Human Services has been working to move Medicare from fee-for-service to value-based payments. It’s seeking to get 90 percent of payments to being value-based by 2...
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California, Aid-in-Dying, and What We've Learned from Oregon from 2015-09-17T16:27:06
The California legislature earlier this month passed a bill that would allow physicians to aid terminally ill patients who wanted to end their lives. California would become the fifth state to enac...
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FDA Guidance on Names for Biologics and Biosimilars and its Implications from 2015-09-10T17:01:45
The U.S. Food and Drug Administration recently released long-awaited draft guidance regarding the naming of biologics, biosimilars, and interchangeable biologics. At the same time the agency releas...
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Understanding the Cost and Value of Cancer Therapies from 2015-09-03T16:23:02
The National Comprehensive Cancer Network in October will release a new tool designed to help doctors understand the value of different cancer therapies by taking into account the costs of treatmen...
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Jimmy Carter's Final Wish: Eradicating Guinea Worm from 2015-08-27T20:16:40
President Jimmy Carter, at a recent press conference discussing his cancer diagnosis and treatment, expressed his wish to outlive the last Guinea worm. The Carter Center, since 1986, has led a glob...
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The Quest for a Pink Viagra from 2015-08-20T18:44:42
Sprout Pharmaceuticals earlier this week won a controversial U.S. Food and Drug Administration approval of Addyi, the first drug approved in the United States to treat female sexual dysfunction. Fo...
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Free Speech Ruling May Force FDA to Rethink Off-Label Marketing from 2015-08-14T16:27:38
Earlier this month in a preemptive challenge from Amarin Pharma against the U.S. Food and Drug Administration a federal judge ruled that the FDA cannot prohibit a drugmaker from promoting the off-l...
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Drugmakers Often Late to Report Serious Side Effects from 2015-08-06T04:45:08
Drugmakers about 10 percent of the time fail to report serious adverse events to the U.S. Food and Drug Administration within the time required, according to a recent study in the Journal of the Am...
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When Hospital Cause, Rather than Cure, Deadly Infections from 2015-07-30T20:41:22
A growing problem with drug resistant infections acquired in hospitals is catching the eye of Consumer Reports, which has added the incidence of two common and deadly infections to their hospital r...
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Rethinking the Value and Price of Drugs from 2015-07-23T15:15:18
The controversy over the high price of new drugs and the question of the value they provide will come under increased scrutiny thanks to a grant to a Boston-based nonprofit that works to get at the...
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Harnessing Stem Cells to Test Drug Safety from 2015-07-16T21:48:28
Researchers at the University of California, Berkeley and the Gladstone Institutes have grown beating cardiac tissue from stem cells in work that may lead to new ways to quickly screen for drugs li...
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CrowdMed Enlists the Wisdom of Crowds to Solve Medical Mysteries from 2015-07-09T23:03:44
For many patients with rare and difficult to diagnose conditions, it can take many years and many doctors to find a correct answer. CrowdMed is trying to offering an alternative to patients by allo...
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Biotech's Record Performance and Looming Threats from 2015-07-02T19:18:15
Last year, the biotechnology industry set records across the board for financial metrics, a reflection of product success, new drug approvals, and free-flowing investment capital. Despite the recor...
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What a Decade of Investment Tells Us about the Health of Biotech from 2015-06-25T14:08:22
A detailed view of funding of emerging therapeutic companies over the past ten years shows despite a rebound in venture financing, companies continue to struggle to find early-stage money. Neverthe...
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What Activist Investors Can Teach Biotech Companies from 2015-06-18T22:35:31
To improve the long-term value of biopharmaceutical companies, management should learn to think more like activist investors, according to a new report from EY. The report argues that capital alloc...
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ALS Fight Carries Muller from Patient to Biotech CEO from 2015-06-11T16:41:19
Bernard Muller was a successful businessman in the maritime and oil industry, but when he was diagnosed with the neurodegenerative disease ALS in 2010, he turned his entrepreneurial skills toward d...
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Examining the State of Sleep from 2015-06-05T04:30:05
Sleep researchers and clinicians will be gathering in Seattle June 6 - 10 for SLEEP 2015, a joint meeting of the American Academy of Sleep Medicine and the Sleep Research Society. It is the largest...
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TheStreet's Adam Feuerstein Previews ASCO 2015 from 2015-05-28T17:40:57
Wall Street’s attention will turn to Chicago as the annual meeting of the American Society of Clinical Oncology runs from May 29 to June 2. Some 5,000 abstracts became available mid-month and inves...
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Home-Brew Morphine, Dual Use Technology, and the Biologist's Repsonsibilities from 2015-05-20T22:50:39
A recent article in Nature Chemical Biology that shows it is possible to convert sugar into morphine with genetically engineered yeast has sparked public attention over the potential illicit use of...
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Reinventing Tech Transfer from 2015-05-14T15:10:37
Universities are moving away from a passive approach to technology transfer to engage with industry in new partnerships, put a greater emphasis on translational research, and nurturing technologies...
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Thinking Narrowly About Antibiotics from 2015-05-07T14:33:49
With the mapping of the human microbiome, a new understanding is emerging of the complex relationship between the microorganisms that live in the human gut, skin, and elsewhere on the body, and the...
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Promise Shown in Different Approach to Alzheimer's from 2015-04-30T13:32:47
AgeneBio is developing drugs to treat the pre-dementia stage of Alzheimer’s disease, and other neurological and psychiatric conditions. The company announced encouraging mid-stage results for its l...
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Innovative Drugs Drive Big Increase in U.S. Spending from 2015-04-23T15:59:32
In April, the IMS Institute released a new report that U.S. drug spending in 2014 rose 13.1 percent to $373.9 billion, the largest single year increase in spending since 2001. A number of factors d...
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Ensuring Digital Health Technologies Benefit Older People from 2015-04-16T19:59:55
AARP, the advocacy group serving people over the age of 50, is taking steps to ensure that digital health technologies best serve its membership. The organization has embarked on an initiative to t...
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How the Sugar Industry Influenced Research to Protect Its Interests from 2015-04-10T17:36:29
A newly discovered archive of documents reveal the sugar industry’s efforts to shape the national research agenda away from the effects of sugar on tooth decay and push for programs to focus on alt...
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Examining The White House's Plan to Combat Drug-Resistant Bacteria from 2015-04-03T16:03:19
Drug resistant bacteria cause 2 million illnesses and approximately 23,000 deaths each year in the United States, according to the U.S. Centers for Disease Control and Prevention. The problem of re...
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Weighing Adverse Events to Get at a Drug's Real Costs from 2015-03-26T18:54:49
Adverse events from drugs cost the U.S. healthcare system an estimated $25 billion in 2013, but data from adverse events reporting is generally not factored into payer and provider decisions about ...
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How One Company Is Reinventing Drug Development from 2015-03-19T21:04:58
Tomasz Sablinski believes the drug development process is broken and has sought to reinvent it. His company, Transparency Life Sciences, relies on crowdsourcing to design its clinical trials, makes...
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Why Patent Trolling Threatens Biopharma from 2015-03-13T23:45:07
The biopharmaceutical industry has long been considered immune to the threat of patent trolls, patent holders who seek to monetize the value of a patent through enforcement rather than productive u...
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Shifting Venture Investment Raises Concerns from 2015-03-05T17:45:16
A first of its kind study of venture investment in therapeutics by disease area and innovation finds that venture investment following the Great Recession has not yet recovered to the levels seen i...
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Will Policy Triumph Over Politics in 21st Century Cures Act from 2015-02-26T21:05:15
At the end of January, after nearly a year of hearings, roundtables, and white papers, the House Energy and Commerce Committee’s Subcommittee on Health released a draft of the much anticipated 21st...
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Democratizing the World of Healthcare Analytics from 2015-02-19T19:29:17
There’s no shortage of data created in the world of healthcare, but harnessing it to improve care and reduce costs remains a challenge. Apervita, backed with $18 million recent venture investment ...
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Will Funding for Obama's Precision Medicine Initiative Match Its Ambition from 2015-02-12T17:22:59
President Obama unveiled the details of his $215 million precision medicine initiative, the centerpiece of which is a 1 million person study that seeks to correlate genetic data, with health record...
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Should Investors Temper Their Enthusiasm for CAR-T Therapies from 2015-02-05T16:21:34
CAR-T cell immunotherapies seek to harness the body’s immune system to fight tumor cells. The promise of this new class of therapies has ignited investor’s imaginations, but a new report from EP Va...
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What to Do About the United States' Declining Investment in R&D from 2015-01-29T01:56:41
Investment in biomedical research in the United States is declining at a time when other countries have been increasing their spending. While this is raising concerns about the threats this poses t...
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Why Big Pharma Hasn't Been Able to Fix Its Revenue Gap with M&A from 2015-01-22T16:55:56
It was an unprecedented year for M&A activity in the life sciences, but even though Big Pharma returned to dealmaking after largely spending 2013 on the sidelines, it’s been unable to close its gro...
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Remembering Industry Pioneer Ron Cape from 2015-01-15T17:33:58
Ron Cape, co-founder, chairman and CEO of Cetus, the first biotechnology company, died earlier this month at 82. Cetus, which developed PCR technology, as well as Betaseron and Interleukin-2,has fa...
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Moving from Chronic Therapies to Cures from 2015-01-08T18:54:28
The rapidly growing area of regenerative medicine is promising to replace chronic therapies with cures. As the biotechnology industry gathers in San Francisco for a big week of meetings, the Allian...
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What's in Store for the Biotech Industry in 2015 from 2014-12-31T16:20:44
As the biotech industry ramps up for the JPMorgan Healthcare conference, we continue our conversation with TheStreet.com’s Adam Feuerstein. In part two of our conversation, we look ahead to what’s ...
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A Look at the Year That Was in Biotech from 2014-12-24T16:52:18
The year 2014 was one for the record books for the biotech industry. In part one of a two-part podcast, we take a look back at the year that was with Adam Feuerstein, senior columnist for TheStreet...
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Why Privacy Concerns May Limit Big Data's Payoff from 2014-12-18T16:33:55
Two-thirds of Americans say they are willing to anonymously share their health information with researchers, but only about 1 in 5 is willing to provide their purchase history or social media activ...
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Calculating the Cost of Drug Development and What it Means from 2014-12-11T01:14:29
The cost of drug development, a metric that underlies discussions ranging from investment in startups to drug pricing, is a matter of great interest and controversy within the pharmaceutical indust...
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How New Funding Models Are Accelerating Drug Development from 2014-12-04T17:41:18
News last month of the Cystic Fibrosis Foundation’s $3.3 billion sale of royalty rights to Kalydeco and other Vertex Pharmaceuticals drugs it helped fund served as a bold statement to the growing p...
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Telemedicine Grows, but Reimbursement Remains an Obstacle from 2014-11-28T04:35:47
While many may think of telemedicine as an example of digital health technologies that will reshape the future landscape of medicine, a new survey from the law firm Foley & Lardner shows it is very...
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The Power of IBM’s Watson Is Coming to an App Near You from 2014-11-20T00:35:12
IBM’s Watson Group recently announced an investment in Pathway Genomics, part of a $100 million initiative by the computing giant to spur innovation in entrepreneurial companies that seek to levera...
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Brittany Maynard and the Debate over the Right to Die from 2014-11-13T18:24:18
Brittany Maynard, a 29-year-old woman with terminal brain cancer who chose to end her own life with a lethal dose of medication, sparked a renewed discussion of so-called death with dignity laws. M...
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What's Driving the Booming Market for Orphan Drugs from 2014-11-06T20:52:06
The market for Orphan drugs is growing at more than twice the rate of other prescription medicines In 2013, a record 260 therapeutics won orphan designations in the United States alone as science, ...
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Why Interoperability Is Much More than a Technology Problem from 2014-10-30T16:02:29
A new government report finds that healthcare providers in the United States are increasing their adoption of health information technology, but their willingness to do so is tied to the incentives...
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The Lean Startup Takes Hold in the Life Sciences from 2014-10-23T20:25:06
The National Science Foundation and the National Institutes of Health, concerned about seeing the science they fund commercialized, have embraced the Lean Startup method as a way to improve the odd...
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Enlisting Monoclonal Antibodies to Combat Bacterial Resistance from 2014-10-16T18:47:05
There’s growing global concern about threat from antibiotic resistant pathogens. That’s leading to new interest in looking beyond traditional antibiotics to monoclonal antibodies to address the pro...
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The Forces Bringing Disruptive Change to Healthcare from 2014-10-09T17:00:20
Scientific breakthroughs, innovations in technology, and the changing use of data are among the forces that are driving disruptive changes to healthcare. A new report from the IMS Institute for Hea...
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How One Foundation is Getting the Biggest Bang for Its R&D Bucks from 2014-10-02T16:00:09
As pressure on government and corporate research budgets grow, organizations like the Multiple Myeloma Research Foundation are playing an increasingly critical role in advancing and accelerating dr...
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International Collaboration Seeks to Drive Breakthroughs in Progressive MS from 2014-09-24T03:24:15
There has been dramatic progress in the understanding and treatment of relapsing remitting multiple sclerosis, a debilitating neurodegenerative disorder. But progressive MS, a more advanced form of...
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Will Increased FDA Regulation of Diagnostics Speed or Slow Development of Personalized Medicine from 2014-09-18T18:29:49
The U.S. Food and Drug Administration is moving to expand its regulatory domain by adding oversight of certain diagnostics it does not regulate today. The agency says thousands of these test are us...
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Using Human Biology to Improve R&D from 2014-09-11T17:15:18
One problem with drug discovery and development is that answers about the way substances act in the human body are often not apparent early in the process. Though human cell assays have been used, ...
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Reengineering Drug Discovery and Development from 2014-09-04T14:45:20
Drugmakers have employed new technologies to reduce the cost and time and it takes develop drugs and produce therapies that more precisely target the underlying biology driving diseases. Boston-bas...
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The Year in Biotech So Far and What's Ahead from 2014-08-28T19:03:33
The biotech sector surged in the first half of the year despite volatile markets. M&A and financing continued to be robust as EvaluatePharma weighed in with its Pharma & Biotech Half-Year Report. W...
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Epirus Sees Opportunities for Biosimilars Outside U.S. from 2014-08-21T16:01:59
The regulatory pathway for biosimilars is still a work in progress at the U.S. Food and Drug Administration, but around the world the industry is growing as regulators have resolved issues that rem...
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