#6 Allele-specific expression - a podcast by Roman Cheplyaka

I talk about allele-specific expression: why it arises and how it can be
reliably detected.

Sections:

• The biology of allele-specific expression (2:17)


• Detecting allele-specific expression with RNA-seq (7:46)


• Mapping and sequencing biases (16:39)


• The experiment in yeast (19:47)


• Statistical models (21:44)

Links:

• A powerful and flexible statistical framework for testing hypotheses of
  allele-specific gene expression from RNA-seq data
  
  
  
  • Supplemenal information
  
  
  
  


• Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data


• The talk by John Marioni


• The blog post explaining the RSEM model

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Further episodes of the bioinformatics chat

Further podcasts by Roman Cheplyaka

Website of Roman Cheplyaka