June 25, 2020 - a podcast by COVID19LST

On today's episode we discuss:

—Climate:  A survey of 2,402 adults in the United States found that 79.5% of respondents supported government-issued stay-at-home orders and nonessential business closures and 77.3% reported they were self-isolating at home suggesting that attitudes broadly support COVID-19 public health interventions.

—Epidemiology:  A study of data on 1353 COVID-19 positive children found the three most common symptoms in these children were fever (21.7%), cough (15.4%), and abnormal breathing (8.1%) with the most severe manifestations, such as intubation or myocarditis, occurring in less than 0.7% of patients, and 1.9% of patients required ICU care.

—Transmission and Prevention:  A report by the Center for Disease Control and Prevention of the COVID-19 outbreak that ocurred on the USS Theodore Roosevelt showed that 60% of respondents exhibited evidence of exposure to SARS-CoV-2 via positive neutralizing antibody assay, ageusia and anosmia were the symptoms most associated with current or previous infection among crew members, and 212 (90.2%) of the 235 respondents that reported a previous positive COVID-19 test via RT-PCR tested positive for neutralizing antibodies.

—Management: Guidelines for managing COVID-19 patients includes:   Diagnosis, treatment, and prevention of venous thromboembolic disease and Donor and candidate selection for transplants.

—Diagnosis and Treatment:  

- A retrospective study found that patients with diminished ovarian reserve who delayed in vitro fertilization treatment (to 90 -180 days from their first visit) had similar live birth rates transfer than those that did not suggesting that delaying IVF in these patients does not affect live birth rate. This data can facilitate decision-making concerning treatment delays and disruptions in this population during the COVID-19 pandemic.

- A meta-analysis of 22 studies assessing the diagnostic efficiency of anti-SARS-CoV-2 IgG and IgM tests found specificities of 99% in both tests and sentisivities of 85% and 74% for IgG and IgM respectively.

- Analysis of SARS-CoV-2 IgM and total antibody levels in 192 patients with severe or mild COVID-19 found no statistically significant differences between mild and severe COVID-19 cases within 6 days of disease onset; however, after day 6, severe cases exhibited higher IgM and a higher overall positivity rate for total antibody titers than that of mild cases. Further, 12/35 mild cases never exhibited IgM positivity and 5/35 remained negative for total antibody titers highlighting the possible limitations in antibody testing of patients with mild COVID-19

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