May 20, 2020 - a podcast by COVID19LST

Your daily COVID-19 LST Report:

—  Climate: A social media questionnaire of 270 men and 189 women in China found reduced sexual behaviors during the COVID-19 era.

— Epidemiology: In a meta-analysis of 21 studies examining the incidence of gastrointestinal symptoms and liver injury in patients with COVID-19, researchers found that 9.1% of patients had diarrhea, 5.2% had nausea/vomiting, and 3.5% had abdominal pain. There was no significant difference in diarrhea or nausea/vomiting between severe and non-severe cases of COVID-19, and these symptoms did not have prognostic value.

— Pathology:  Researchers present a comprehensive review on SARS-CoV-2 immunopathology, describe putative mechanisms for cell-specific pathogenesis based on current research and studies on SARS-CoV and MERS-CoV. Notable mechanisms in pathogenesis include early interferon production and activation of NK cells as crucial steps to mitigate COVID-19 severity.

— Management: Guidelines and recommendations for:

• Ethical allocation of scarce medications 


• Managing seizure episodes


• Changing the delivery method of aerosolized medications


• Managing and treating acute kidney injury


• Coordinating rectal cancer treatment


• In a case series of 24 awake, hospitalized COVID-19 patients without mechanical ventilation, 15 tolerated prone positioning with 6 responding with more than 20% increase in partial pressure of arterial oxygen, leading the authors to recommend further studies to explore its efficacy.

— Adjusting Practice: Guidelines and recommendations for practice during the pandemic:.  Dental care, Control of infection in trauma surgery. Diagnosis, treatment, and monitoring of obstructive sleep apnea.   Prioritization of surgical services.  

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