Ep. 76: Why Caloric Restriction Is NOT Responsible For Lifespan Extension (Hormesis Part 2) - a podcast by Jay Feldman Wellness

from 2021-12-02T07:42:59

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In this episode we discuss:

How the largest body of evidence cited in favor of hormesis actually doesn’t support it at all

Why caloric restriction is NOT responsible for slowing aging and extending lifespan (and what is actually responsible)

The many factors that confound the calorie restriction research (including differences between organisms, poor research design, amino acid restriction, PUFA, endotoxin, and more)

Timestamps:

3:36 – the physiology of hormesis and the general support for hormesis

12:54 – outlining the problems with hormesis

18:51 – how differences between organisms confound the caloric restriction research

37:34 – the problem with using proxy markers to evaluate health effects and the importance of context

48:20 – how differences between organisms confound the caloric restriction research (cont.)

51:58 – how hydration status and macronutrient ratios confound the caloric restriction research

55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables

1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research

1:11:58 – how PUFA confounds the caloric restriction research

1:30:09 – how endotoxin and gut health confound the caloric restriction research