In this episode we discuss:
Why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
The involvement of uncoupling, mitochondrial biogenesis, autophagy, heat shock proteins, and hypoxia-inducible factors in the stress response
How stress prevents our mitochondria from effectively producing energy
How chronic stress causes insulin resistance, high blood pressure, weight gain, depression, and cardiovascular disease
How sugar and fat cravings result from stress and why listening to them is beneficial
How adaptations to stress get passed on through generations
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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/
Timestamps:
0:00 – intro
2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids
6:05 – the short-term effects of catecholamines
8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling
14:40 – the protective effects of uncoupling as a part of the stress response
20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response
37:33 – the effect of acute stress on energy production in mitochondria
45:18– the effect of chronic stress on energy production in mitochondria
48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states
1:05:24 – the relationship between mental health, mood, and metabolic function
1:10:21 – how adaptations to stress get passed on through mitochondrial DNA
1:18:32 – how to best improve mitochondrial function and our health
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