Podcasts by This Week in Neuroscience
A podcast about the nervous system.
Further podcasts by Vincent Racaniello
Podcast on the topic Biowissenschaften
All episodes
TWiN 44: ADHD and persistent pain from 2023-11-02T22:03
TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.
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TWiN 43: Pavlovian opioid tolerance from 2023-10-04T15:34
TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning.
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TWiN 42: Therapeutic effects of psychedelic drugs from 2023-07-18T02:02
TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critic...
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TWiN 41: Alzheimer's and melanin-concentrating hormone from 2023-06-20T04:00
Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced...
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TWiN 40: Dopamine organizes behavior's syllables from 2023-05-11T17:20
Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release c...
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TWiN 39: Virus-like capsids trigger paraneoplastic disease from 2023-04-28T11:30
Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome....
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TWiN 38: Bacterial immunity heals sensory neurons from 2023-03-27T04:00
TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.
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TWiN 37: Microglia at the crossroads from 2023-01-23T05:00
TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions.
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TWiN 36: Unbearable neurologists from 2023-01-03T21:43
TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain.
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TWiN 35: Neuromodulation in treatment-resistant depression from 2022-12-06T21:03
Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvemen...
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TWiN 34: Microglia vital after spinal cord injury from 2022-09-30T04:00
TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice.
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TWiN 33: Viruses leaving the brain from 2022-08-31T14:02:22
TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull.
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TWiN 32: Relearning how to move after stroke from 2022-08-02T22:44:24
TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together.
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TWiN 31: HIV-1 co-receptor shapes window for memory linking from 2022-06-29T17:07:23
TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories.
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TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease from 2022-05-24T19:53:52
TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to fea...
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TWiN 29: Astrocytes close the critical period from 2022-05-02T19:43:18
TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits.
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TWiN 28: Oligodendrocyte performance enhancing exosomes from 2022-04-04T17:45:13
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins.
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TWiN 27: Eyes wired to the auditory cortex from 2022-03-03T20:41:30
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex.
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TWiN 26: Immunological memory in the brain from 2022-01-31T13:06:03
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses.
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TWiN 25: Thanks for listening from 2021-12-28T12:17:12
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival.
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TWiN 24: Social transmission of maternal behavior with Ioana Carcea and Robert Froemke from 2021-11-24T19:38:57
Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litte...
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TWiN 23: Peripheral nervous system with Bruce Carter from 2021-10-31T14:32:38
Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells,...
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TWiN 22: It's never lupus from 2021-09-29T20:51:58
TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory.
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TWiN 21: How do we know if a mouse is hallucinating? from 2021-08-24T04:00
TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum.
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TWiN 20: Drifting aromas in the brain from 2021-07-14T17:43:13
While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over pe...
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TWiN 19: Glia 101 from 2021-06-21T15:31:37
On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its ...
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TWiN 18: Autism and the gut microbiome with Mauro Costa-Mattioli from 2021-05-12T16:15:26
Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorder...
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TWiN 17: Worms see the light with Michael Nitabach from 2021-04-21T14:05:47
Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmf...
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TWiN 16: Neuronal depolarization with Stefano Brigidi from 2021-03-17T21:50:09
Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.
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TWiN 15: Microbiome and neurodevelopment with Helen Vuong from 2021-02-17T14:57:24
Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.
TWiN 14: Reducing Alzheimer-like pathology in mice from 2021-01-14T21:57:01
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of A...
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TWiN 13: mRNAs for long-term memory from 2020-12-15T19:28:03
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.
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TWiN 12: A gene for short-term memory from 2020-11-11T15:27:27
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.
TWiN 11: A dollar per neuron from 2020-10-14T00:58:21
Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.
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TWiN 10: Remodeling synapses with a cytokine from 2020-09-29T02:03:21
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.
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TWiN 9: COVID-19 neurology with Genna Waldman from 2020-08-11T05:00
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.
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TWiN 8: Replacing lost neurons from 2020-07-07T18:00
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.
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TWiN 7: Stress, the good, bad and beautiful from 2020-06-13T13:43:13
The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.
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TWiN 6: Neural control of sexual behavior from 2020-05-20T01:36:06
Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.
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TWiN 5: Anosmia and COVID-19 from 2020-04-18T19:40:39
Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19.
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TWiN 4: It's a trap! from 2020-01-09T02:35:45
Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons.
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TWiN 3: Gambling on dopamine from 2019-12-18T00:30:02
Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction.
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TWiN 2: Cells that fire together wire together from 2019-11-05T16:33:16
The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is inv...
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TWiN 1: The ultimate challenge from 2019-10-26T19:39:35
The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast.
Hosts: Ori Lieberman Listen