TWiPO #13 ~ Updates, epidemiology of CNS tumors, birth order, and cell phone risks - a podcast by Solving Kids Cancer

August
19, 2011

Host Dr. Tim Cripe and co-hosts Dr. Lionel Chow
and Dr. Jim Geller discuss updates to previous TWiPO episodes reporting on
recent press coverage and publications of BiTE antibodies and modified T-cell
approaches, and then discuss recent studies on birth defects, birth order, and
cell phone use and possible link to risk of childhood cancers.

N Engl J Med. 2011 Aug 10. Chimeric Antigen Receptor-Modified T Cells in Chronic
Lymphoid Leukemia.

Sci Transl Med 10 August 2011: T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and
Can Establish Memory in Patients with Advanced Leukemia;
Vol. 3, Issue 95, p. 95ra73

7:40 Decitabine upregulation of NY-ESO-1 and
MAGE family expression in NB. MAGE-A1, MAGE-A3, and NY-ESO-1 can be upregulated on neuroblastoma cells
to facilitate cytotoxic-T lymphocyte-mediated tumor cell killing,
K Lucas

9:50 Discussion of Rosenberg paper on
immunotherapy in solid tumors; Nat Rev Clin Oncol. 2011 Aug 2. doi:
10.1038/nrclinonc.2011.116. Cell transfer immunotherapy for
metastatic solid cancer-what clinicians need to know.
Rosenberg SA

13:00 Birth anomolies in CNS pediatric tumors

29:00 Absolute risk is small; will this lead to
genome-wide association studies?

31:51 Birth order and risk of
pediatric cancers

42:30 Mobile phone use and incidence
of pediatric CNS tumors.

46:47 Listener question about time elapse of
planning clinical trials to opening.

Please send any comments or questions to
twipo@solvingkidscancer.org

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