TWiPO #15 ~ MicroRNAs and hereditary cancer - a podcast by Solving Kids Cancer

September
28, 2011

Join host Dr. Tim Cripe with his co-hosts Drs.
Jim Geller, Lionel Chow, and Lars Wagner in a robust discussion with special
guest Dr. Kathryn Wikenheiser-Brokamp on the implications of DICER1, rare tumor
registries, and difficult issues surrounding genetic counseling.

Kathryn A. Wikenheiser-Brokamp, MD, PhD, is an
Associate Professor in Pathology and Pulmonary Biology at Cincinnati Children's
Hospital Medical Center. Her research is focused on pediatric and adult lung diseases,
including cancer. She seeks to determine the molecular mechanisms underlying
Rb/p16, p53, and Dicer1 pathway function in lung development and the
pathogenesis of lung disease. Dr. Wikenheiser-Brokamp holds a PhD in
Developmental Biology, Developmental Biology and an MD from University of
Cincinnati.

Papers discussed:

DICER1 syndrome: clarifying the diagnosis, clinical features and
management implications of a pleiotropic tumour predisposition syndrome.
J Med Genet. 2011 Apr;48(4):273-8.

Extending the Phenotypes Associated with DICER1 Mutations.
Hum Mutat. 2011 Aug 31. doi: 10.1002/humu.21600.

Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1
mutations: a report from the International Pleuropulmonary Blastoma Registry.
Gynecol Oncol. 2011 Aug;122(2):246-50.

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twipo@solvingkidscancer.org

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