TWiPO #26 ~ Killer Immunoglobulin Receptor (KIR) Mismatch in Neuroblastoma - a podcast by Solving Kids Cancer

May
07, 2012

In this interesting episode, host Dr. Tim Cripe
(Nationwide Children's) and co-hosts Dr. Lionel Chow (Cincinnati Children's),
Dr. Andy Kolb (AI DuPont), and Donna Ludwinski (Solving Kids' Cancer) quiz Dr
Paul Sondel and Dr. Ken DeSantes (both from University of Wisconsin - Madison)
on NK cells and the implications of KIR/KIR-ligand mismatch (killer
immunoglobulin-like receptor) with regard to immunotherapy treatment of
neuroblastoma.

References:

Delgado DC, Hank JA, Kolesar J, Lorentzen D, et
al. Genotypes of NK cell KIR receptors, their ligands, and Fcγ receptors in the
response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res.
2010 Dec 1;70(23):9554-61. Epub 2010 Oct 8.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999644/

.

Venstrom JM, Zheng J, Noor N, Danis KE, et al.
KIR and HLA genotypes are associated with disease progression and survival
following autologous hematopoietic stem cell transplantation for high-risk
neuroblastoma. Clin Cancer Res. 2009 Dec 1;15(23):7330-4. Epub 2009 Nov 24.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788079/

.

Alderson KL, Sondel PM. Clinical cancer therapy
by NK cells via antibody-dependent cell-mediated cytotoxicity. J Biomed
Biotechnol. 2011;2011:379123. Epub 2011 May 24.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110303/

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