TWiPO #5 ~ Hedgehog Signaling and Itraconazole - a podcast by Solving Kids Cancer

May
19, 2011

Discussion of the role of hedgehog signaling
and repositioning of drugs for pediatric cancers such as anti-fungal drug
itraconazole

In this fifth episode, hosts Dr. Tim Cripe and
Dr. Maureen O'Brien discuss the role of targeting of hedgehog signaling in
diffuse intrinsic pontine glioma (DIPG) and the use of drugs designed for other
uses -- designed for other uses -- such as itraconazole, an anti-fungal drug
found to suppress hedgehog signaling -- as a possible treatment for
medulloblastoma.

1:20 feedback and comments on previous TWiPO
episode

2:58 Hedgehog-responsive candidate cell of origin for diffuse intrinsic
pontine glioma; (fulltext) Proc Natl Acad Sci U S A. 2011
March 15; 108(11): 4453–4458

9:22 Itraconazole,
a commonly used antifungal that inhibits Hedgehog pathway activity and cancer
growth. Cancer Cell. 2010 Apr 13;17(4):388-99.

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