TWiPO #8 ~ Seneca Valley virus and medulloblastoma - a podcast by Solving Kids Cancer

June
09, 2011

An oncolytic virus
for a common childhood brain tumor

In this eighth episode of "This Week in Pediatric
Oncology" podcast hosts Dr. Tim Cripe, Dr. Lars Wagner and Dr. Lionel Chow
discuss a recent publication by researchers at Baylor/Texas Children's in
Houston that shows remarkable results of Seneca Valley virus SVV-001 on
orthotopic mouse models of medulloblastoma.

The TWiPO hosts raise many interesting points
about this research and highlight the strengths as well as limitations of this
work. This exciting research provides new evidence of promise for oncolytic
virus therapy for childhood tumors.

For more information about oncolytic virus
trials for pediatric cancers, see a recent webinar "Oncolytic Virotherapy for
Pediatric Solid Tumors" presented by the principal
investigators of five clinical trials in children and sponsored by Solving
Kids' Cancer.

The article discussed in this episode can be
found here:

A single intravenous injection of oncolytic picornavirus SVV-001
eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse
models. Yu L, Baxter PA, et al. Neuro Oncol. 2011
Jan;13(1):14-27. Epub 2010 Nov 12.

Another related article by the same group:

Treatment of invasive retinoblastoma in a murine model using an oncolytic
picornavirus. Wadhwa L, Hurwitz MY, et al. Cancer Res. 2007
Nov 15;67(22):10653-6. [fulltext]

Please send questions or comments to
twipo@solvingkidscancer.org

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