In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-C...
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This Week in Virology is a netcast about viruses - the kind that make you sick.
Further podcasts by Vincent Racaniello
Podcast on the topic Wissenschaft
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TWiV 1069: European CDC with Eeva Broberg from 2023-12-10T05:00
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control.
TWiV 1068: Clinical update with Dr. Daniel Griffin from 2023-12-09T06:05:58
In his weekly clinical update, Dr. Griffin discusses developmental impairment in children exposed during pregnancy to maternal SARS-COV2, vagus nerve dysfunction in the post-COVID-19 condition, ...
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TWiV 1067: Heads or tails, you win a phage lunch from 2023-12-03T05:00
On this all-bacteriophage episode, TWiV explains the ‘vampire phage’, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival.
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TWiV 1066: Clinical update with Dr. Daniel Griffin from 2023-12-02T05:00
In his weekly clinical update, Dr. Griffin discusses a microbiologist who was harassed during COVID pandemic sues university, use of inactivated poliovirus vaccine for poliovirus outbreak respon...
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TWiV 1065: Cat coronavirus gains function in Cyprus from 2023-11-26T05:00
TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cy...
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TWiV 1064: Clinical update with Dr. Daniel Griffin from 2023-11-25T05:00
In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-...
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TWiV 1063: Childhood paralysis with Kevin Messacar from 2023-11-19T05:00:58
Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other dis...
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TWiV 1062: Clinical update with Dr. Daniel Griffin from 2023-11-18T07:19:51
In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-1...
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TWiV 1061: Seasonal COVID and a niche for cervical cancer from 2023-11-12T05:00
TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an...
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TWiV 1060: Clinical update with Dr. Daniel Griffin from 2023-11-11T05:00
In his weekly clinical update, Dr. Griffin discusses stress in America 2023, CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, misse...
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TWiV 1059: Keeping poliovirus out and Ebolavirus in from 2023-11-05T04:00
On this episode of TWiV we discuss unusual properties of monoclonal antibodies: one that that binds the receptor attachment site and blocks infection with all three poliovirus serotypes, and oth...
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TWiV 1058: Clinical update with Dr. Daniel Griffin from 2023-11-04T04:00
In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection o...
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TWiV 1057: CMV-based HIV vaccine with Klaus Früh from 2023-10-29T04:00
Klaus Früh visits the Incubator to discuss his career and his work on cytomegalovirus-vectored vaccines which are unique in their ability to persistently maintain an immune shield of effector me...
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TWiV 1056: Clinical update with Dr. Daniel Griffin from 2023-10-28T04:00
In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection o...
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TWiV 1055: Vermont viridae from 2023-10-22T04:00
Vincent travels to the University of Vermont to speak with Jason, Emily, Jessica, and Dimitry about their careers and their work on SARS-CoV-2, hantaviruses, poliovirus, influenza virus, and the...
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TWiV 1054: Clinical update with Dr. Daniel Griffin from 2023-10-21T04:00
In his weekly clinical update, Dr. Griffin discusses high Influenza incidence and disease severity among children and adolescents aged <18 years, neurologic effects of SARS-CoV-2 transmitted amo...
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TWiV 1053: Bird flu in Baltimore from 2023-10-15T04:00
From the Centers for Excellence in Influenza Research and Response meeting in Baltimore, Vincent speaks with Ron Fouchier, Rafael Medina, and Louse Moncla about recent changes in the epidemiolog...
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TWiV 1052: Clinical update with Dr. Daniel Griffin from 2023-10-14T04:00
In his weekly clinical update, Dr. Griffin discusses disease severity of RSV compared with COVID-19 and Influenza among hospitalized adults aged ≥60 years, antiviral efficacy of Molnupiravir ver...
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TWiV 1051: Like SARS-CoV-2 in the headlights from 2023-10-08T04:00
TWiV reviews the 2023 Nobel Prize in Physiology or Medicine awarded to Katalin Karikó and Drew Weissman for their identification nucleoside base modifications that enabled the development of eff...
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TWiV 1050: Clinical update with Dr. Daniel Griffin from 2023-10-07T04:00
In his weekly clinical update, Dr. Griffin discusses the effectiveness of maternal mRNA COVID-19 vaccination during pregnancy against COVID-19–associated hospitalizations in infants aged <6 mont...
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TWiV 1049: Long COVID's book of homeostatic cats from 2023-10-01T04:00
TWiV explains how immune profiling was used to identify distinguishing features of Long COVID, and how a co-opted feline endogenous retroviral envelope promotes cell survival by controlling copp...
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TWiV 1048: Clinical update with Dr. Daniel Griffin from 2023-09-30T04:00
In his weekly clinical update, Dr. Griffin discusses a molnupiravir-associated mutational signature in global SARS-CoV-2 genomes, inhaled fluticasone furoate for outpatient treatment of COVID-19...
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TWiV 1047: Long COVID and avian flu in ferrets from 2023-09-24T04:00
TWiV explains a study of postacute sequelae of COVID-19 at 2 years, and respiratory droplet transmission of human-isolated avian H3N8 influenza virus between ferrets.
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TWiV 1046: Clinical update with Dr. Daniel Griffin from 2023-09-23T04:00
In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-de...
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TWiV 1045: Less Lassa, CRISPR RNA viruses from 2023-09-17T04:00
TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses.
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TWiV 1044: Clinical update with Dr. Daniel Griffin from 2023-09-16T04:00
In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 souther...
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TWiV 1043: Marion Koopmans on COVID-19, Mpox, H5N1, polio and One Health from 2023-09-10T04:00
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent ou...
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TWiV 1042: Clinical update with Dr. Daniel Griffin from 2023-09-09T04:00
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respi...
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TWiV 1041: Novel oral polio vaccine? with Raul Andino and Kostya Chumakov from 2023-09-03T04:00
Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradic...
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TWiV 1040: Clinical update with Dr. Daniel Griffin from 2023-09-02T10:00
In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused...
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TWiV 1039: Landmines for phages, a mouthful of redondoviruses from 2023-08-27T04:00
TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozo...
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TWiV 1038: Clinical update with Dr. Daniel Griffin from 2023-08-26T04:00
In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infan...
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TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful from 2023-08-20T04:00
TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after imm...
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TWiV 1036: Clinical update with Dr. Daniel Griffin from 2023-08-19T04:00
In his weekly clinical update, Dr. Griffin discusses Florida local transmission of dengue cases reported in Broward and Miami-Dade counties, infants admitted to US intensive care units for RSV i...
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TWiV 1035: Poxvirus wars, warp speed COVID-19 vaccine rollout from 2023-08-13T04:00
TWiV dissects a study of COVID-19 vaccination which shows that the timing of initial rollout affects disease outcomes more substantially than final coverage or degree of socioeconomic disparity,...
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TWiV 1034: Clinical update with Dr. Daniel Griffin from 2023-08-12T04:00
In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, ass...
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TWiV Special: Toppling the anti-vaxxer pyramid with "flu-shot cheerleader" Desiree Townsend from 2023-08-11T04:00
Vincent speaks with Desirée Townsend about how she felt used and indoctrinated by the anti-vaxx movement, the science surrounding her autoimmune disorder, and why she is no longer the “flu shot ...
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TWiV 1033: Freediving with nanobodies and interferon from 2023-08-06T04:00
TWiV notes the passing of Harald zur Hausen, dengue breaking records in the Americas, inhibition of SARS-CoV-2 infection and inflammation by modulation of type I IFN, and an armed nanobody that ...
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TWiV 1032: Clinical update with Dr. Daniel Griffin from 2023-08-05T04:00
In his weekly clinical update, Dr. Griffin discusses predicting COVID-19 incidence using wastewater surveillance data, use of wastewater metrics to track COVID-19 in the US, wastewater-based epi...
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TWiV 1031: Death on the West Nile from 2023-07-30T04:00
TWiV notes the passing of virologist Michael BA Oldstone, a study to assess the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, and the presence o...
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TWiV 1030: Clinical update with Dr. Daniel Griffin from 2023-07-29T04:00
In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Centr...
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TWiV 1029: David Tuller on Long COVID and ME/CFS from 2023-07-27T04:00
David Tuller returns to TWiV to provide an update on ME/CFS, the PACE trial, developments related to the NICE guidelines, and how similar practices and ideologies are being applied to long COVID...
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TWiV 1028: Asymptomatic SARS-CoV-2 infection and T cells from 2023-07-23T04:00
TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA...
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TWiV 1027: Clinical update with Dr. Daniel Griffin from 2023-07-22T04:00
In his weekly clinical update, Dr. Griffin discusses the transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States, Omicron subvariant BA.5 efficiently infects lung cells...
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TWiV 1026: Debunking RFK Jr.’s vaccine funk with Dan Wilson from 2023-07-16T04:00
Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience.
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TWiV 1025: Clinical update with Dr. Daniel Griffin from 2023-07-15T04:00
In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 ...
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TWiV 1024: The Chumakoviridae from 2023-07-14T04:00
Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test f...
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TWiV 1023: Covering science with Katherine Wu from 2023-07-09T04:00
Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and ...
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TWiV 1022: Clinical update with Dr. Daniel Griffin from 2023-07-08T04:00
In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therap...
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TWiV 1021: Nextstrain with Trevor Bedford from 2023-07-02T04:00
From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evol...
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TWiV 1020: Clinical update with Dr. Daniel Griffin from 2023-07-01T04:00
In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: anti...
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TWiV 1019: Eddie Holmes on SARS-CoV-2 origins from 2023-06-25T04:00
From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other orig...
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TWiV 1018: Clinical update with Dr. Daniel Griffin from 2023-06-24T04:00
In his weekly clinical update, Dr. Griffin discusses the CDC vaccine advisory group recommending the newly approved RSV vaccines, association of culturable-virus detection and household transmis...
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TWiV 1017: From Nature, not a lab from 2023-06-18T04:00
Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, an...
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TWiV 1016: Clinical update with Dr. Daniel Griffin from 2023-06-17T04:00
In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1...
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TWiV 1015: Soldiers&Scientists at USAMRIID from 2023-06-11T04:00
Vincent and Rich travel to Ft. Detrick to visit USAMRIID and speak with Todd, Crystal, John and Jay about their careers, their research, and the mission of the US Army Medical Institute of Infec...
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TWiV 1014: Clinical update with Dr. Daniel Griffin from 2023-06-10T04:00
In his weekly clinical update, Dr. Griffin discusses estimates of SARS-CoV-2 seroprevalence and incidence of primary SARS-CoV-2 infections among blood donors, by COVID-19 vaccination status, sma...
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TWiV 1013: Bird flu around the world from 2023-06-04T04:00
TWiV reviews remarkable changes in the epidemiology of avian H5N1 influenza virus leading to previously uninfected areas, involvement of previously unaffected wild birds, and devastating outbrea...
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TWiV 1012: Clinical update with Dr. Daniel Griffin from 2023-06-03T04:00
In his weekly clinical update, Dr. Griffin discusses the potential for recurrent Mpox outbreaks among gay, bisexual, and other men who have sex with men, association between SARS-CoV-2 variants ...
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TWiV 1011: Aquatic viruses from 2023-05-28T04:00
Vincent travels to Québec City, Canada and the 11th Aquatic Virus Workshop, where he speaks with Fred Aylward and Jed Furman about the research of their laboratories on the ecology and evolution...
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TWiV 1010: Clinical update with Dr. Daniel Griffin from 2023-05-27T04:00
In his weekly clinical update, Dr. Griffin discusses the CDC HIV surveillance report, FDA voted in favor of approving the Abrysvo vaccine, canine olfactory detection of SARS-CoV-2-infected human...
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TWiV 1009: Nidovirus on the water from 2023-05-21T04:00
Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kant...
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TWiV 1008: Clinical update with Dr. Daniel Griffin from 2023-05-20T04:00
In his weekly clinical update, Dr. Griffin discusses variant specific clinical performance of a SARS-CoV-2 rapid antigen test with focus on omicron VOC, ventilation in buildings, COVID-19 mortal...
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TWiV 1007: Fragile DNA, viruses, cancer from 2023-05-14T04:00
TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile ...
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TWiV 1006: Clinical update with Dr. Daniel Griffin from 2023-05-13T04:00
In his weekly clinical update, Dr. Griffin discusses immunogenicity and tolerability of a bivalent virus-like particle norovirus vaccine candidate in children from 6 months up to 4 years of age,...
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TWiV 1005: COVID T vax and a virus from the blue from 2023-05-07T04:00
TWiV reveals plankton-infecting relatives of herpesviruses in the sunlit oceans, and a vaccine encoding non-spike T cell antigens that protects animals from severe SARS-CoV-2 infection.
H...
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TWiV 1004: Clinical update with Dr. Daniel Griffin from 2023-05-06T04:00
In his weekly clinical update, Dr. Griffin discusses the U.S. Food and Drug Administration approving Arexvy: the first respiratory syncytial virus (RSV) vaccine approved for use in the United St...
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TWiV 1003: Going clinically viral from 2023-04-30T04:00
Vincent and Kathy travel to Atlanta for APHL ID Lab Con, a conference focused on the latest developments in detection and characterization of infectious diseases of public health concern, and ...
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TWiV 1002: Clinical update with Dr. Daniel Griffin from 2023-04-29T04:00
In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learne...
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TWiV 1001: Clinical update with Dr. Daniel Griffin from 2023-04-23T16:00
In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospital...
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TWiV 1000: Live from New York, 1k epitopes of virology from 2023-04-23T03:33:04
The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy.
Host...
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TWiV 999: Vaccinated to the nines from 2023-04-09T04:00
TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an e...
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TWiV 998: Clinical update with Dr. Daniel Griffin from 2023-04-08T04:00
In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with...
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TWiV 997: Inside Omicron with Mohsan Saeed from 2023-04-02T04:00
Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the publi...
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TWiV 996: Clinical update with Dr. Daniel Griffin from 2023-04-01T04:00
In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood type...
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TWiV 896: Memory B cells, the way we were from 2022-05-01T04:00
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost....
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TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin from 2022-04-30T04:00
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines...
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TWiV 894: Dinner with the TMPRSS family from 2022-04-28T23:41:44
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.
Hosts...
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TWiV 893: Yellow fever virus escapes antibodies from 2022-04-24T04:00
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by...
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TWiV 892: COVID-19 clinical update #111 with Dr. Daniel Griffin from 2022-04-23T04:00
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, v...
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TWiV 891: LLOV in the time of Ebola from 2022-04-21T04:00
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.
... Listen
TWiV 890: Looking into a booster crystal ball from 2022-04-17T04:00
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval bet...
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TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin from 2022-04-16T04:00
In COVID-19 clinical update #110, Dr. Griffin covers hospital admissions during variant outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in child...
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TWiV 888: Molnupiravir with Richard Plemper from 2022-04-14T04:00
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs fo...
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TWiV 887: Bonfire of the monocytes from 2022-04-10T13:08:25
TWiV explains why this season’s influenza vaccine is not protecting against mild to moderate disease caused by H3N2 virus, and that antibody-dependent entry of SARS-CoV-2 into monocytes is a maj...
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TWiV 886: COVID-19 clinical update #109 with Dr. Daniel Griffin from 2022-04-09T04:00
In COVID-19 clinical update #109, Daniel Griffin discusses cardiac complications after infection or vaccination, long COVID in children, fourth vaccine dose in Israel, no need for fourth vaccine...
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TWiV 885: Russian bats and Ankara vectors from 2022-04-07T04:00
TWiV reveals an ACE2-dependent sarbecovirus from Russian bats that is not inhibited by anti-SARS-CoV-2 antibodies, and a modified vaccinia virus Ankara vectored vaccine that protects nonhuman pr...
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TWiV 884: Cytokines and viral mimicry from 2022-04-03T04:00
Vincent and Amy explain how asthmatic bronchial smooth muscle increases rhinovirus replication in the bronchial epithelium, and mimicry of IL-17 by the ORF8 protein of SARS-CoV-2.
Hosts: ...
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TWiV 883: COVID-19 clinical update #108 with Dr. Daniel Griffin from 2022-04-02T04:00
In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine...
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TWiV 882: Elispot on about T cells and lipids from 2022-03-31T04:00
Vincent and Brianne review the need to better understand T cell responses to SARS-CoV-2 infection to better inform public health decisions, and how IL-1 and IL-1ra are important regulators of th...
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TWiV 880: COVID-19 clinical update #107 with Dr. Daniel Griffin from 2022-03-26T04:00
In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pr...
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TWiV 879: Indolent, resistant, and losing our TMPRSS from 2022-03-24T04:00
TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant in...
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TWiV 878: Shape matters sometimes from 2022-03-20T14:21:05
TWiV revisits chronic wasting disease of cervids and the ability of the prions to infect meadow voles and raccoons, and the suggestion that stochastic assembly of influenza virus particles may p...
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TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin from 2022-03-19T04:00
In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus ad...
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TWiV 876: Spillover market with Michael Worobey from 2022-03-17T04:00
Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic.
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TWiV 875: Animal house from 2022-03-13T05:00
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.
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TWiV 874: COVID-19 clinical update #105 with Dr. Daniel Griffin from 2022-03-12T05:00
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, h...
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TWiV 873: Pig viruses and big viruses from 2022-03-06T05:00
TWiV reviews the six known coronaviruses that infect pigs and what can be learned about human infections, and how the giant Mimivirus DNA genome is organized into a nucleocapsid.
Hosts: <...
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TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin from 2022-03-05T13:24:30
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for ...
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TWiV 871: If the ACE2 fits, ferret from 2022-02-27T05:00
TWiV discusses whether or not Omicron should be designated a new serotype of SARS-CoV-2, and the finding that amino acid changes that adapt SARS-CoV-2 to mink or ferret do not increase fitness i...
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TWiV 870: COVID-19 clinical update #103 with Dr. Daniel Griffin from 2022-02-26T05:00
In COVID-19 clinical update #102, Daniel Griffin covers immunocompromised people, hospitalization of children, vaccine usage update, Omicron and cross-reactive neutralizing antibodies, reinfecti...
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TWiV 869: Epstein-Barr virus and MS, a perfect storm from 2022-02-20T16:39:51
TWiV reviews epidemiological and experimental evidence that infection with Epstein-Barr virus leads to the production of antibodies against a viral protein that cross-react with a human protein,...
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TWiV 868: COVID-19 clinical update #102 with Dr. Daniel Griffin from 2022-02-19T05:00
In COVID-19 clinical update #102, Daniel Griffin reviews children and COVID, effectiveness of maternal vaccination, vaccines for immunocompromised, primary care physicians and vaccination rates,...
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TWiV 867: I love the smell of vaccines in the morning from 2022-02-17T05:00
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates...
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TWiV 866: EV antibodies rEVolutionize our thinking from 2022-02-13T05:00
Amy returns to TWiV to discuss her work on the identification of cross-reactive antibody responses among diverse enteroviruses, and the implications for our understanding of viral pathogenesis a...
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TWiV 865: COVID-19 clinical update #101 with Dr. Daniel Griffin from 2022-02-12T05:00
In COVID-19 clinical update #101, Daniel Griffin discusses children and COVID, human challenge study results, effectiveness of mask use, Omicron boost in macaques, mucosal vaccine candidate, lon...
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TWiV 864: A game of thrones from 2022-02-10T14:55:56
Monica, John, David, and Marc join TWiV to discuss their work on identifying cryptic SARS-CoV-2 lineages in New York City wastewater, and understanding whether they were shed from humans or othe...
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TWiV 863: Does this challenge study pass the smell test? from 2022-02-06T05:00
TWiV reviews the results of a study in which 36 volunteers were infected with SARS-CoV-2, and what was learned about the kinetics of virus reproduction in the nose and throat, development of sym...
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TWiV 862: COVID-19 clinical update #100 with Dr. Daniel Griffin from 2022-02-05T13:39:08
In COVID-19 clinical update #100, Daniel Griffin, from Accra, Ghana, reviews the challenges in evaluating Omicron severity, over 800 deaths in children, Pfizer vaccine EUA application for under ...
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TWiV 861: Rough draft of Omicron origins from 2022-02-04T02:31:37
Nels joins TWiV to discuss hypotheses for the origins of Omicron, including that it came from mice or arose during chronic infection of an immunocompromised patient.
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TWiV 860: Evading a Toll on the road to RNA vaccines from 2022-01-30T05:00
TWiV reviews a seminal paper showing that chemically modified bases in RNAs suppress recognition by Toll-like receptors, a finding that that was essential for the development of COVID-19 mRNA va...
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TWiV 859: COVID-19 clinical update #99 with Dr. Daniel Griffin from 2022-01-29T05:00
In COVID-19 clinical update #99, Daniel Griffin discusses Omicron disease severity, neurologic manifestations in children, testing outcomes during multiple infections, boosters improve VE and VD...
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TWiV 858: The vax of life with John Mascola from 2022-01-28T02:40:25
John Mascola joins TWiV to discuss the history and mission of the NIH Vaccine Research Center, how it prepared for devising pandemic vaccines, and development of the COVID-19 vaccines.
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TWiV 857: Not just antibody, Jon Yewdell from 2022-01-23T18:22:01
Jon Yewdell returns to TWiV to discuss how antibodies are made, vaccination against SARS-CoV-2, antigenic variation of the virus, booster shots, and more.
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TWiV 856: COVID-19 clinical update #98 with Dr. Daniel Griffin from 2022-01-22T05:00
In COVID-19 clinical update #98, Daniel Griffin reviews COVID-19 in South Africa, recognition of Omicron by ancestral T cells, booster effectiveness against disease, infection and vaccination in...
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TWiV 855: T time with Alessandro Sette from 2022-01-21T02:31
Alessandro Sette returns to TWiV to discuss the observation that SARS-CoV-2 vaccination induces T cells that are able to cross-recognize variants Alpha to Omicron.
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TWiV 854: Omicron is evasive from 2022-01-16T20:01:01
TWiV reviews findings that increased fitness of the Omicron variant is due to immune evasion, not an increase in intrinsic transmissibility, and determination of infectious viral load in patient...
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TWiV 853: COVID-19 clinical update #97 with Dr. Daniel Griffin from 2022-01-15T05:00
In COVID-19 clinical update #97, Daniel Griffin covers immunity after infection recognized by CDC, outcomes before and after Omicron, infectious viral load in Delta vs Omicron, PCR vs rapid anti...
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TWiV 852: Tree man syndrome from 2022-01-13T05:00
A TWiV threesome explains the observation that humans with inherited T cell CD28 deficiency are susceptible to severe warts driven by human papilloma virus infection, but are otherwise healthy.<...
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TWiV 851: Questions are tricky from 2022-01-09T19:52:13
The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters.
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TWiV 850: COVID-19 clinical update #96 with Dr. Daniel Griffin from 2022-01-08T05:00
In COVID-19 clinical update #96, Daniel Griffin reviews Omicron in South Africa, rapid antigen tests, viral coinfections, isolation and quarantine, saliva preferred for Omicron, risk factors for...
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TWiV 849: Arc of the epitope from 2022-01-07T17:58:14
TWiV kicks off 2022 with a review of the virology highlights of 2021, from three virologists, one immunologist, a science writer, and a partridge in a pear tree.
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TWiV 847: On Dasher, on Dancer, on Corona and Lassa from 2022-01-02T05:00
For the final episode of 2021, TWiV reviews an experimental infectious attenuated Lassa fever vaccine based on a codon-deoptimized glycoprotein gene, and SARS-CoV-2 infection of free-ranging whi...
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TWiV 848: COVID-19 clinical update #95 with Dr. Daniel Griffin from 2022-01-01T05:00
In COVID-19 clinical update #95, Daniel Griffin discusses new CDC guidelines for isolation and quarantine, EUA for Molnupiravir, children and COVID, vaccine safety in 5-11 year olds, Omicron out...
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TWiV 846: Beta was stirring, and now in a mouse from 2021-12-26T05:00
TWiV explores the impact of the intestinal virome on seroconversion after rotavirus vaccination, and implications of the ability of the SARS-CoV-2 beta variant to infect wild-type laboratory mic...
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TWiV 845: COVID-19 clinical update #94 with Dr. Daniel Griffin from 2021-12-25T05:00
In COVID-19 clinical update #94, Daniel Griffin reviews the FDA EUA for Paxlovid, test to stay in school, immunity after infection, variants and therapeutics, quarantine and isolation guidelines...
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TWiV 844: Paul Offit on children, COVID, and boosters from 2021-12-19T05:00
Paul Offit returns to TWiV to discuss new CDC guidance on J&J vaccine, why children should be immunized against COVID-19, and whether or not booster doses are scientifically justified.
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TWiV 843: COVID-19 clinical update #93 with Dr. Daniel Griffin from 2021-12-18T05:00
In COVID-19 clinical update #93, Dr. Griffin summarizes Omicron fitness, S-gene target failure, monoclonal efficacy against Omicron, vaccination, monoclonals, and disease in children, persistenc...
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TWiV 842: The clot thickens from 2021-12-16T05:00
TWiV reviews the results of serum neutralization assays which show that a third vaccine dose restores neutralization of the Omicron variant, and interaction of platelet factor 4 with the adenovi...
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TWiV 841: Unmasking immunity from 2021-12-12T05:00
TWiV provides an update on immunity to Omicron, results of a randomized controlled trial of face masks, and a study of correlates of protection against respiratory syncytial virus infection in t...
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TWiV 840: COVID-19 clinical update #92 with Dr. Daniel Griffin from 2021-12-11T05:00
In COVID-19 clinical update #92, Dr. Griffin reviews emerging data on the Omicron variant, much information about monoclonal antibody treatment, including expansion of EUA for Lilly’s cocktail, ...
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TWiV 839: The long and the short of it: get vaccinated from 2021-12-09T16:20:25
TWiV reviews the impact of vaccination on SARS-CoV-2, the latest information on Omicron, West Nile virus transmission by organ transplantation, and why a 16 week interval between doses of BNT162...
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TWiV 838: The magic virus bus from 2021-12-05T05:00
The New York City Virus Hunters join TWiV to reveal how local students engage in safe virus surveillance and conduct science research right in their neighborhoods, followed by an update on varia...
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TWiV 837: COVID-19 clinical update #91 with Dr. Daniel Griffin from 2021-12-04T05:00
In COVID-19 clinical update #91, Dr. Griffin discusses final results of molnupiravir trial, Omicron variant of concern, outcomes in B-cell depleted patients, recovery in T-cell depleted macaques...
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TWiV 836: OMG, Omicron! from 2021-12-02T05:00
TWiV reveals all that we know so far about the variant of concern B.1.1.529, also called Omicron, and describes a study on the ability of the alpha, beta, and delta variants to reproduce in cell...
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TWiV 835: Giving thanks for antibodies from 2021-11-28T05:00
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recove...
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TWiV 834: COVID-19 clinical update #90 with Dr. Daniel Griffin from 2021-11-27T05:00
In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for still...
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TWiV 833: Grand theft kinesin from 2021-11-25T16:17:03
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles.
Host...
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TWiV 832: Heavy metal flu fighters from 2021-11-21T05:00
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral in...
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TWiV 831: COVID-19 clinical update #89 with Dr. Daniel Griffin from 2021-11-20T05:00
In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of an...
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TWiV 830: A culture of resistance from 2021-11-18T12:34:08
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and descr...
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TWiV 829: Antiviral and cytotoxically empowered for COVID-19 from 2021-11-14T05:00
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an ora...
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TWiV 828: COVID-19 clinical update #88 with Dr. Daniel Griffin from 2021-11-13T05:00
TWiV 827: A shot to save the world with Greg Zuckerman from 2021-11-07T04:00
Greg Zuckerman joins TWiV to discuss his book that explores the race to produce COVID-19 vaccines, with insights into the companies, scientists, and executives involved and the rivalries, ambiti...
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TWiV 826: COVID-19 clinical update #87 with Dr. Daniel Griffin from 2021-11-06T04:00
In COVID-19 clinical update #87, Dr. Griffin reviews PCR cycle threshold and RNA copy number, rapid antigen tests, hospitalization rate after infection or vaccination, allergies and vaccination,...
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TWiV 825: COVID-19 Q&A with Dr. Daniel Griffin from 2021-11-01T04:00
In this special live-streamed episode of TWiV, Dr. Daniel Griffin fields questions on SARS-CoV-2 and COVID-19 from listeners.
Hosts: Daniel G...
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TWiV 824: Immunogoblins in the nose and lungs from 2021-10-31T04:00
TWiV explores the properties of the spike glycoproteins of an influenza B virus discovered in the Wuhan spiny eel, and protection against SARS-CoV-2 infection one year after mRNA-1273 vaccinatio...
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TWiV 823: COVID-19 clinical update #86 with Dr. Daniel Griffin from 2021-10-30T04:00
In COVID-19 clinical update #86, Dr. Griffin discusses virologic features of infection in children, antibody tests should not be used to asses level of protection, test-to-stay programs in schoo...
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TWiV 822: Viking variola variants from 2021-10-28T14:39:49
Rich reviews the history of smallpox and the discovery of variola viral genomes in ancient DNA from human remains throughout Northern Europe, which pushes back the earliest date of smallpox viru...
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TWiV 821: Public clonotype #1 from 2021-10-24T04:16:50
A TWiV trio reveal the isolation of novel paramyxoviruses from rodents and bats in Arizona, and isolation of naive B cells from seronegative donors that produce germline encoded antibodies which...
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TWiV 820: COVID-19 clinical update #85 with Dr. Daniel Griffin from 2021-10-23T04:00
In COVID-19 clinical update #85, Dr. Griffin reviews cases and deaths by vaccination status, mRNA vaccine effectiveness in 12-18 year olds, standard and extended dosing of mRNA vaccines, immune ...
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TWiV 819: How to stall a copy machine from 2021-10-21T21:05:07
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in...
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TWiV 818: Thor's hammer from 2021-10-17T04:00
The TWiVers review phase 3 efficacy and safety results for the Novavax COVID-19 vaccine, effects on the neonatal immune system caused by maternal infection with SARS-CoV-2, and NHC, the metaboli...
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TWiV 817: COVID-19 clinical update #84 with Dr. Daniel Griffin from 2021-10-16T04:00
In COVID-19 clinical update #84, Dr. Griffin discusses childrens’ antibody response to vaccination, phase 3 results of Novavax vaccine, heterologous vaccination, antithrombotic therapy, EUA for ...
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TWiV 816: Long COVID and ME/CFS with David Tuller from 2021-10-15T18:18:01
David Tuller returns to TWiV to revisit his work to expose the methodological and ethical problems with the PACE trial, and the post-acute sequelae to SARS-CoV-2 infection, also known as long CO...
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TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar from 2021-10-10T04:00
Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell recepto...
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TWiV 814: COVID-19 clinical update #83 with Dr. Daniel Griffin from 2021-10-09T12:53:27
In COVID-19 clinical update #83, Daniel Griffin discusses upcoming FDA discussions on vaccines, strategies to prevent transmission at youth camps, outbreaks at summer camps, impact of vaccinatio...
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TWiV 813: COVID-19 at the European Society for Clinical Virology from 2021-10-07T16:40:15
From the 2021 online meeting of the European Society for Clinical Virology, Vincent speaks with meeting speakers on COVID-19 vaccines, immunity, how countries responded to the pandemic, and how ...
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TWiV 812: Bespoke capsids delivered from 2021-10-03T04:00
TWiV considers lessons learned from COVID-19 about emergency drug use during a pandemic, and selection of AAV capsids to produce vectors that efficiently deliver genes to muscle cells.
Ho...
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TWiV 811: COVID-19 clinical update #82 with Dr. Daniel Griffin from 2021-10-02T13:07:48
In COVID-19 clinical update #82, Daniel Griffin reviews vaccines for 5-12 years old, safety of a third vaccine dose, Oklahoma reinfection data, Regencov outcomes, Pfizer protease inhibitor, impa...
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TWiV 810: Opening Pandora's box from 2021-09-30T16:59:28
TWiV reviews how a novel technology enabled development of COVID-19 mRNA vaccines, and discovery of a proton gradient and an incomplete TCA cycle in a giant. virus.
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TWiV 809: Vampire vax from 2021-09-26T04:00
TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire b...
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TWiV 808: Clinical update #81 with Dr. Daniel Griffin from 2021-09-25T04:00
In COVID-19 clinical update #81, Daniel Griffin discusses vaccine boosters, vaccination during pregnancy, mRNA vaccine comparison, J&J vaccine booster, EUA expansion for Lilly monoclonals, remde...
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TWiV 807: The shot yearned 'round the world with Chadi Saad-Roy and Caroline Wagner from 2021-09-19T04:00
Chadi and Caroline join TWiV to describe the potential epidemiological and evolutionary impacts of vaccine nationalism, and their modeling which emphasizes the importance of rapid equitable vacc...
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TWiV 806: COVID-19 clinical update #80 with Dr. Daniel Griffin from 2021-09-18T04:00
In COVID-19 clinical update #80, Daniel Griffin reviews infections in children, masking, testing to limit transmission, high barrier for monoclonal antibody escape, are boosters needed, use of s...
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TWiV 805: Delta and boosters from 2021-09-16T04:00
The TWiVotopes review current evidence which does not show the need for widespread COVID-19 booster vaccination, and results of experiments to examine the replication and immune evasion of the S...
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TWiV 804: A tangled web of viruses with Mya Breitbart from 2021-09-12T04:00
Virus hunter Mya Breitbart joins TWiV to describe her laboratory’s work on viruses in spiders, insects, millipedes, freshwater springs, seawater, plants, human feces and much more.
Hosts:...
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TWiV 803: COVID-19 clinical update #79 with Dr. Daniel Griffin from 2021-09-11T04:00
In COVID-19 clinical update #79, Daniel Griffin discusses clinical management guidelines, ER visits and hospitalization among children, infection and vaccine induced seroprevalence in the US, an...
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TWiV 802: Another epitope with Shane Crotty from 2021-09-09T04:00
Shane Crotty returns to TWiV to review the immunology of COVID-19, including differences between infection and vaccination, increased breadth of antibodies after infection followed by vaccinatio...
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TWiV 801: We can hear the coffin from 2021-09-05T04:00
The meteorologicomaniacs discuss the COVID-19 pandemic global death toll, effectiveness of vaccines against the delta variant, and how analysis of ancient viral DNA reveals that two pathogenic h...
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TWiV 800: COVID-19 clinical update #78 with Dr. Daniel Griffin from 2021-09-04T04:00
In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-ho...
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TWiV 799: A very model of a modern TWiV from 2021-09-02T04:00
TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens...
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TWiV 798: Rats, more coronaviruses! from 2021-08-29T04:00
The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated a...
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TWiV 797: COVID-19 clinical update #77 with Dr. Daniel Griffin from 2021-08-28T04:00
In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynam...
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TWiV 796: The vary hungry spike with Paul and Theodora from 2021-08-22T04:00
Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a poly...
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TWiV 795: COVID-19 clinical update #76 with Dr. Daniel Griffin from 2021-08-21T04:00
In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vacci...
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TWiV 794: PAMS spray SARS-CoV-2 from 2021-08-15T04:00
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection.
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TWiV 793: COVID-19 clinical update with Dr. Daniel Griffin from 2021-08-14T04:00
In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk...
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TWiV 792: Transmission with Jeffrey Shaman from 2021-08-12T04:00
Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors ...
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TWiV 791: A mad virologists' T party from 2021-08-08T04:00
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from S...
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TWiV 790: COVID-19 clinical update #74 with Dr. Daniel Griffin from 2021-08-07T04:00
In COVID-19 clinical update #74, Daniel Griffin covers infections in vaccinated individuals, expansion of Regeneron monoclonal antibody cocktail for prophylaxis, neutralization of variants by an...
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TWiV 789: Does delta mean a change? from 2021-08-05T04:00
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease. Listen
TWiV 788: neuroCOVID with Kiran Thakur, MD from 2021-08-01T03:50:55
Kiran joins TWiV to discuss the findings of a team at Columbia University Medical Center on COVID-19 neuropathology, and the conclusion that SARS-CoV-2 does not reproduce in the central nervous ...
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TWiV 787: COVID-19 clinical update #73 with Dr. Daniel Griffin from 2021-07-31T04:00
In COVID-19 clinical update #73, Daniel Griffin reviews updated mask guidance from CDC, infections in public school district employees, effectiveness of vaccines against delta variant, antibody ...
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TWiV 786: You make mucus and you move it from 2021-07-29T04:00
TWiVsters review off-season epidemics of respiratory syncytial virus in Australia after easing of COVID-19 restrictions, and impaired innate immune responses in upper respiratory tract cells fro...
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TWiV 785: COVID-19 Q&A with Dr. Daniel Griffin from 2021-07-28T04:00
In this special episode, Daniel Griffin answers listener questions on COVID-19 vaccines, vaccine misinformation, long COVID, masking and distancing, school safety, and much more.
Hosts: <...
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TWiV 784: Virtually live from ASV from 2021-07-25T04:00
Moriah and Joseph join the nearly complete TWiV team to discuss their work on genetic variation and adaptability in herpes simplex virus, and how rotavirus infection ...
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TWiV 783: COVID-19 clinical update #72 with Dr. Daniel Griffin from 2021-07-23T19:30:49
In COVID-19 clinical update #72, Daniel Griffin covers long term symptoms in children, outcomes for MIS-C, recent guidance from the American Academy of Pediatrics, a large well traced outbreak o...
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TWiV 782: An antibody for all sarbecoviruses from 2021-07-22T04:00
On this episode, broadening of immune responses to SARS-CoV-2 after mRNA vaccine booster to ChAdOx1 nCoV-19, five-fold underestimation of the number of cases in the US during the first six month...
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TWiV 781: My genome is left to tell the tale from 2021-07-18T04:00
The Team with Invincible Values discusses whether dogs or cats passively carry SARS-CoV-2 on hair and foot pads, maternal to fetal transfer of antibodies in infected or vaccinated pregnant women...
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TWiV 780: COVID-19 clinical update #71 with Dr. Daniel Griffin from 2021-07-17T04:00
In COVID-19 clinical update #71, Daniel Griffin reviews updated school and child care guidance from CDC, transmission in schools, accuracy of lateral flow assays, update to J&J/Janssen vaccine E...
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TWiV 779: Evolving boosterism from 2021-07-11T04:00
TWiV reviews evidence that COVID-19 mRNA vaccination of both uninfected and previously infected persons elicits cross-variant neutralizing antibodies, and directed evolution of a bacterial prote...
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TWiV 778: COVID-19 clinical update #70 with Dr. Daniel Griffin from 2021-07-10T11:30:17
In COVID-19 clinical update #70, Daniel Griffin discusses efficacy of portable air cleaners, vaccine induced serum neutralizing antibodies against variants, prevention and attenuation of disease...
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TWiV 777: SARS-CoV-2 fitness with Ron Fouchier from 2021-07-08T04:00
Ron Fouchier explains why increased transmission of SARS-CoV-2-variants has not been demonstrated, and their ability to displace ancestral variants is due to greater fitness, much like influenza...
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TWiV 776: Yes! We have no pangolins from 2021-07-04T04:00
TWiV reviews an analysis of animal sales from Wuhan wet markets before the COVID-19 pandemic, control of dengue by release of Wolbachia-infected mosquitoes, and fatal dengue acquired in...
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TWiV 775: COVID-19 clinical update #69 with Dr. Daniel Griffin from 2021-07-03T04:00
In COVID-19 clinical update #69, Daniel Griffin covers effectiveness of mRNA vaccines against the delta variant, depression among public health workers, correlates of...
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TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences from 2021-07-01T04:00
Kristian Andersen and Robert Garry join TWiV to discuss recovery of deleted deep sequencing data from early in the Wuhan SARS-CoV-2 epidemic, and whether they shed light on the early phase of th...
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TWiV 773: Laurie Garrett, pandemic prophet from 2021-06-27T04:00
Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife market...
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TWiV 772: COVID-19 clinical update #68 with Dr. Daniel Griffin from 2021-06-26T04:00
In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in re...
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TWiV 771: Borna hundred million years ago from 2021-06-20T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 770: COVID-19 clinical update #67 with Dr. Daniel Griffin from 2021-06-19T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 769: MIS-C and leaky gut from 2021-06-17T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 768: Can nanobody stop these variants? from 2021-06-13T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 767: COVID-19 clinical update #66 with Dr. Daniel Griffin from 2021-06-12T13:38:07
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 766: The CORONA project with David Fajgenbaum from 2021-06-10T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 765: Potpourri of COVID-19 from 2021-06-06T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 764: COVID-19 clinical update #65 with Dr. Daniel Griffin from 2021-06-05T14:42:38
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 763: Cap-snatch fever from 2021-06-03T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 762: SARS-CoV-2 origins with Robert Garry from 2021-05-30T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 761: COVID-19 clinical update #64 with Dr. Daniel Griffin from 2021-05-29T13:32:09
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans from 2021-05-27T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 759: Pork dogs and an evolutionary pickle from 2021-05-23T04:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 758: COVID-19 clinical update #63 with Dr. Daniel Griffin from 2021-05-22T04:00
In COVID-19 clinical update #63, Daniel Griffin reviews cases at child care facilities, estimates of mRNA vaccine effectiveness, risk of reinfection in university students, enhanced antibody genera...
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TWiV 757: Supershedders and super vaccines from 2021-05-20T04:00
TWiV reveals that 2% of SARS-CoV-2?positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pand...
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TWiV 756: Precluding problematic polio prophylaxis from 2021-05-16T04:00
TWiV returns to the 2012 brouhaha over transmission experiments with avian H5N1 influenza virus, re-examines the claim of SARS-CoV-2 RNA integration into human DNA, and reviews the engineering and ...
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TWiV 755: COVID-19 clinical update #62 with Dr. Daniel Griffin from 2021-05-15T13:41:03
In COVID-19 clinical update #62, Daniel Griffin covers outdoor transmission of the virus, safe use of NSAIDS, expansion of Pfizer/BioNTech vaccine to include 12-15 year olds, post-disease Mucormyco...
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TWiV 754: Tuesday two: SARS-CoV-2 and TLR2 from 2021-05-13T04:00
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and...
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TWiV 753: The ferret nose where the virus goes from 2021-05-09T04:00
TWiV revisits Brazil’s rejection of Sputnik vaccine, examines influenza transmission via the air from the nasal epithelium of ferrets, and a history of accidental releases of polioviruses and their...
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TWiV 752: COVID-19 clinical update #61 with Dr. Daniel Griffin from 2021-05-08T12:43:26
In COVID-19 clinical update #61, Daniel Griffin reviews a modeling of future hospitalizations and deaths by vaccination rates and non pharmaceutical intervention scenarios, performance evaluation o...
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TWiV 751: Sputnik spat and furin in ferrets from 2021-05-06T04:00
TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction ...
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TWiV 750: To err is viral from 2021-05-02T04:00
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like vir...
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TWiV 749: COVID-19 clinical update #60 with Dr. Daniel Griffin from 2021-05-01T12:56:47
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global cas...
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TWiV 748: SARS-CoV-2 gets a sense of humoral from 2021-04-25T04:00
A TWiV trio explains a method for sequencing single genomes of SARS-CoV-2 and its use to explore in-host evolution drive by antibody responses, and incidence of cerebral venous thrombosis in COVID-...
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TWiV 747: COVID-19 clinical update #59 with Dr. Daniel Griffin from 2021-04-24T13:28:35
Daniel Griffin discusses a front-line health care worker survey, pre-exposure seropositivity and subsequent infection in healthy young adults, fitted filtration efficiency of double masking, BinaxN...
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TWiV 746: Encephalitis viruses dine on caveolae from 2021-04-22T04:00
Team TWiV explains how alphaviruses like Western equine encephalitis virus cross into the brain from capillaries by caveolin-mediated transcytosis, and reveal scientists’ incentives and attitudes t...
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TWiV 745: Gorilla COVID with Nadine Lamberski from 2021-04-18T04:00
Nadine Lamberski joins TWiV to discuss an outbreak of COVID-19 among gorillas at the San Diego Zoo, and the use of a spike protein-based vaccine to immunize the animals.
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TWiV 744: COVID-19 clinical update #58 with Dr. Daniel Griffin from 2021-04-17T14:11:50
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, u...
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TWiV 743: Shape-shifting viruses from 2021-04-15T04:00
The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such ...
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TWiV 742: De-fusing COVID-19 from 2021-04-11T04:00
TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramb...
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TWiV 741: COVID-19 clinical update #57 with Dr. Daniel Griffin from 2021-04-10T13:19:14
In COVID-19 clinical update #57, Daniel Griffin covers children and MIS-C, school opening plans, transmission event with masks, fomite transmission, diagnostic test performance, AZ vaccine and bloo...
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TWiV 740: Complementation will get you everywhere from 2021-04-08T04:00
The Guardians of the TWiV-o-verse discuss the process of codon deoptimization for the production of experimental infectious attenuated viral vaccines, and how a respiratory syncytial virus with 619...
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TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall from 2021-04-04T04:00
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct rando...
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TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin from 2021-04-03T14:34:53
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic aci...
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TWiV 737: SARS-CoV-2 in NYC wastewater from 2021-04-01T04:00
John, Monica, and Davida join TWiV to discuss development of a method to detect SARS-CoV-2 in raw sewage from all 14 of New York City’s treatment plants, and its use to determine the presence of th...
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TWiV 736: Rhapsody in T with Alessandro Sette from 2021-03-28T06:00
Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in conval...
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TWiV 735: COVID-19 clinical update #735 with Dr. Daniel Griffin from 2021-03-26T22:08:13
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on...
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TWiV 735: COVID-19 clinical update #55 with Dr. Daniel Griffin from 2021-03-26T22:08:13
In COVID-19 clinical update #55, Daniel Griffin reviews recommendations for keeping transmission low in school settings, optimal testing strategies for schools and businesses, impact of vaccines on...
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TWiV 734: Weiss hath no furin like a virus scorned from 2021-03-21T05:00
Susan Weiss returns to TWiV to discuss coronavirus entry into cells and the role of spike protein cleavage by proteases, why lab escaped hypotheses for SARS-CoV-2 are unlikely, and modulation of in...
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TWiV 733: COVID-19 clinical update #54 with Dr. Daniel Griffin from 2021-03-20T05:00
In COVID-19 clinical update #54, Daniel Griffin covers effectiveness of 3 vs 6 ft physical distancing, effectiveness of masks, physical distancing, and eye shields, second vaccine dose completion, ...
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TWiV 732: Citizen science with Forest Rohwer and Maria-Isabel Rojas from 2021-03-18T05:00
Forest and Maria-Isabel join TWiV to discuss their their project to engage thousands of citizens to swab inanimate surfaces in the San Diego area, then send the samples to the Rohwer Lab for nuclei...
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TWiV 731: The kids aren't alright from 2021-03-14T06:00
On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and rece...
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TWiV 730: COVID-19 clinical update #53 with Dr. Daniel Griffin from 2021-03-13T14:46:36
In COVID-19 clinical update #53, Daniel Griffin reviews underreporting of infections and long term disease in children, a blood test for T cells, results of phase 3 trials for monoclonal antibodies...
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TWiV 729: A floret of spikes with Matt Frieman from 2021-03-11T06:00
Matt Frieman returns to TWiV to discuss the COVID-19 pandemic from the point of view of a coronavirologist, including his work with Novavax on their spike protein-based vaccine.
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TWiV 728: Cover your nose and mouse from 2021-03-07T06:00
TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and ...
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TWiV 727: COVID-19 clinical update #52 with Dr. Daniel Griffin from 2021-03-06T15:45:05
In COVID-19 clinical update #52, Daniel Griffin reviews differences in attack rates between children and adults, J&J vaccine phase III data, G6PD deficiency and vaccines, NIH halts convalescent pla...
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TWiV 726: Molecular animator Janet Iwasa from 2021-03-04T06:00
Janet Iwasa joins TWiV to recount how she became a molecular animator, including a pivot during her Ph.D. thesis research, the value of animations in science, and their latest animation of SARS-CoV...
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TWiV 725: Eva Harris and Janet Smith clip flavivirus wings from 2021-02-28T06:00
Eva Harris and Janet Smith join TWiV to discuss how an antibody against dengue virus NS1 protein blocks endothelial dysfunction and the potential of treating infections by multiple flaviviruses.
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TWiV 724: COVID-19 clinical update #51 with Dr. Daniel Griffin from 2021-02-27T16:20:06
In COVID-19 clinical update #51, Daniel Griffin reviews use of two masks, effectiveness of testing in nursing homes, updates on vaccines, use of nonsteroidal anti-inflammatory drugs, little effect ...
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TWiV 723: COVID-19 palliative care with Ginger Campbell, MD from 2021-02-25T06:00
Ginger Campbell joins TWiV to discuss palliative care for COVID-19 patients, and how to approach the disease from a goals of care perspective.
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TWiV 722: More coronaviruses in the pipeline from 2021-02-21T06:00
The entire TWiV team assembles to discuss resurgence of COVID-19 in Manaus, Brazil, discovery of SARS-CoV-2 related viruses in bats in Southeast Asia, and increased Ct values after administration o...
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TWiV 721: COVID-19 clinical update #50 with Dr. Daniel Griffin from 2021-02-20T17:37:23
In COVID-19 clinical update #50, Daniel Griffin discusses CDC guidance on school opening, decreased viral load after vaccination, randomized clinical trial of vitamin D treatment, a study of zinc p...
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TWiV 720: With vaccines, Offit is on it from 2021-02-14T06:00
Paul Offit joins TWiV to discuss all things vaccine, including how COVID-19 vaccine development was accelerated, whether the vaccines are safe and efficacious, the difference between an EUA and a l...
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TWiV 719: COVID-19 clinical update #49 with Dr. Daniel Griffin from 2021-02-13T16:28:21
In COVID-19 clinical update #49, Daniel Griffin discusses CDC guidelines on mask use, drop in test frequency in the US, resurgence of COVID-19 in Brazil, possible impact of Pfizer vaccine on viral ...
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TWiV 718: Recombining vaccine schedules from 2021-02-11T06:00
TWiV explores single dose administration and timing of second dose of AZD1222 COVID-19 vaccine, safety and efficacy of Sputnik V, and control of coronavirus recombination by a viral proofreading ex...
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TWiV 717: Paul and Theodora, pandemic explorers from 2021-02-07T06:00
Theodora and Paul return to TWiV to explain how they quickly pivoted their retrovirus laboratories towards SARS-CoV-2, their work on the antibody response to infection and its durability, and the e...
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TWiV 716: COVID-19 clinical update #48 with Dr. Daniel Griffin from 2021-02-06T16:06:29
In COVID-19 clinical update #48, Daniel Griffin reviews effect of spike amino acid changes on neutralization with monoclonal antibodies, Sputnik V safety and efficacy results, increased reactogenic...
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TWiV 715: Fauci ouchy from 2021-02-04T06:00
TWiV explains why hydroxychloroquine failed in humans despite showing antiviral effects in cells, and reviews the published data on the Pfizer/BioNTech mRNA vaccine.
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TWiV 714: The shape of spike with Jason McLellan from 2021-01-31T06:00
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-in...
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TWiV 713: COVID-19 clinical update #47 with Dr. Daniel Griffin from 2021-01-30T16:02:18
In COVID-19 clinical update #47, Daniel Griffin reviews phase 3 results for Novavax and J&J vaccines, transmission in K-12 settings in Wisconsin, data on Lilly and Regeneron monoclonal antibody the...
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TWiV 712: Deutscher Virus Wahnsinn from 2021-01-28T06:00
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.
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TWiV 711: The New Heal from 2021-01-24T06:00
The TWiVers review Biden’s national strategy for the COVID-19 responses and pandemic preparedness, and an evaluation of the BinaxNOW rapid antigen test for SARS-CoV-2 infection.
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TWiV 710: COVID-19 clinical update #46 with Dr. Daniel Griffin from 2021-01-23T15:45:08
In COVID-19 clinical update #46, Daniel Griffin discusses the BinaxNow rapid antigen test, efficacy of Bamlanivimab in nursing homes, associations of serum vitamin D concentrations with in-hospital...
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TWiV 709: COVID cherry picking from 2021-01-21T06:00
In this episode, President Biden elevates his science advisor to his Cabinet, a review of the current flu season, the scientific goals of the WHO-convened Global Study of the Origins of SARS-CoV-2,...
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TWiV 708: Alpaca llama full of nanobodies from 2021-01-17T06:00
The TWiVy team deconstructs CoronaVac, the inactivated SARS-CoV-2 vaccine produced by Sinovac Biotech, and production of multivalent camelid nanobodies that block infection with the virus and suppr...
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TWiV 707: COVID-19 clinical update #45 with Dr. Daniel Griffin from 2021-01-16T18:05:22
In COVID-19 clinical update #45, Daniel Griffin discusses J&J Ad26 vaccine results, reactogenicity after the second dose of mRNA vaccines, expansion of vaccine eligibility, and the finding that enc...
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TWiV 706: Do as Dr. Fauci says from 2021-01-14T06:00
TWiV answers listener questions about pandemic response, excess deaths in 25-44 year olds, vaccines, vaccines, and vaccines.
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TWiV 705: Rocky Mountain COVID with Emily Travanty from 2021-01-10T06:00
Emily Travanty from the Colorado Department of Public Health and Environment joins TWiV to discuss how her laboratory was the first in the US to detect the SARS-CoV-2 variant VOC 202012/01.
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TWiV 704: COVID-19 clinical update #44 with Dr. Daniel Griffin from 2021-01-09T18:06:34
In this COVID-19 clinical update, Daniel Griffin summarizes current status of vaccination in the US, discusses a study on convalescent sera from Argentina, use of remdesivir in patients with kidney...
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TWiV 703: Does dose matter? from 2021-01-07T06:00
On this episode, a discussion of why modifying the dose schedule of the mRNA vaccines in the US is not a good idea, evidence that lower Ct values on hospital admission is associated with higher mor...
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TWiV 702: Year of the Pandemic from 2021-01-03T06:00
For this first episode of 2021, the complete TWiV team reviews compelling virology stories of 2020, and thanks the multitude of guests who have helped us to navigate the pandemic, and our many list...
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TWiV 701: COVID-19 clinical update #43 with Dr. Daniel Griffin from 2021-01-02T02:26:37
In Daniel Griffin’s final clinical report for 2020, he summarizes what we have learned about the clinical management of COVID-19 patients in the past year.
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TWiV 700: 'Twas COVID and the aerosols from 2020-12-31T06:00
TWiV reviews additional data on the UK variant of SARS-CoV-2, the distinct variant spreading in South Africa, association of afucosylated antiviral IgG with severe COVID-19, approval of AstraZeneca...
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TWiV 699: Arboviruses at ASTMH from 2020-12-27T06:00
From the 2020 online meeting of the American Society for Tropical Medicine and Hygiene, Vincent speaks with Jonathan Auguste, Carol Blair, Desiree LaBeaud, Louis Lambrechts, and Mauricio Nogueira a...
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TWiV 698: COVID-19 clinical update #42 with Dr. Daniel Griffin from 2020-12-26T18:00:20
Daniel Griffin provides his weekly clinical report on COVID-19, including his own experience with vaccination, guidelines for vaccine distribution, reasons for under-utilization of monoclonal antib...
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TWiV 697: The sky is NOT falling from 2020-12-24T06:00
TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovi...
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TWiV 696: Tear down that SARS-CoV-2 manuscript from 2020-12-20T06:00
TWiV explains that COVID-19 is not harmless for young adults, FAA approval for Pfizer mRNA vaccine, lack of justification for the claim of reverse transcription of SARS-CoV-2 RNA and integration in...
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TWiV 695: COVID-19 clinical update #41 with Dr. Daniel Griffin from 2020-12-18T18:48:40
Daniel Griffin provides his weekly clinical report on COVID-19, including thoughts on the first immunizations with Pfizer mRNA vaccine, the anticipated EUA for the Moderna vaccine, whether the vacc...
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TWiV 694: Mitigating COVID-19 from 2020-12-17T06:00
On this episode, TWiV makes Bloomberg Business News 2020 Jealousy List, crushing of CDC revealed by insiders, seasonal influenza during the COVID-19 pandemic, FDA briefing documents from Moderna, a...
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TWiV 693: Vax to the future from 2020-12-13T06:00
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets.
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TWiV 692: COVID-19 clinical update #40 with Dr. Daniel Griffin from 2020-12-11T22:43:09
Daniel Griffin provides his weekly clinical report on COVID-19, including the anticipated EUA for the Pfizer mRNA vaccine, mitigation strategies in early care and education settings, expressive aph...
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TWiV 691: SciArt with Laura Splan from 2020-12-10T06:00
SciArtist Laura Splan joins TWiV to reveal her transdisciplinary work that intersects science, technology, design and culture, then we discuss an inverse correlation between mumps virus antibodies ...
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TWiV 690: This is your brain on SARS-CoV-2 from 2020-12-06T06:00
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous...
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TWiV 689: COVID-19 clinical update #39 with Dr. Daniel Griffin from 2020-12-05T16:58:43
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP,...
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TWiV 688: We put COVID-19 papers through a sieve from 2020-12-03T06:00
On this episode, UK grants EUA for Pfizer vaccine, advice for CDC on who to immunize first, news from Das Coronavirus, SARS-CoV-2 protease regulates innate responses, and viral mRNAs are not an ind...
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TWiV 687: Peter Hotez sticks to the vax from 2020-11-29T06:00
Peter Hotez joins TWiV to discuss the COVID-19 pandemic, including why it went out of control in the US, the hijacking of public health practices by anti-science extremist groups, prospects for con...
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TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin from 2020-11-28T15:39:18
Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and R...
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TWiV 685: Pandemicky from 2020-11-26T06:00
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Provin...
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TWiV 684: Persistence of SARS-CoV-2 immune memory from 2020-11-22T06:00
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might ...
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TWiV 683: Two COVID-19 mRNA vaccines from 2020-11-19T06:00
On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body.
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TWiV 682: Kate Rubins from the International Space Station from 2020-11-17T06:00
From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth.
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TWiV 681: Crowley, coats, and cross-reactive antibodies from 2020-11-15T06:00
Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the pre...
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TWiV 680: Long-term COVID and ME/CFS from 2020-11-12T06:00
Mady, Fiona, and David join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS.
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TWiV 679: Mink, mutation, and myocytes from 2020-11-08T06:00
Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why ...
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TWiV 678: Fishing for viruses with Nels Elde from 2020-11-05T06:00
Nels joins TWiV to reveal the discovery of a picornavirus of zebrafish by measuring immune responses in the host, genome sequence analysis of the White House COVID-19 outbreak, and a six-fold highe...
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TWiV 677: Does antibody really know what time it is? from 2020-11-01T05:00
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SA...
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TWiV 676: Tragic gene flow from Neanderthals from 2020-10-29T05:00
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-...
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TWiV 675: Forget what you've herd about immunity from 2020-10-25T05:00
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SA...
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TWiV 674: In the company of coronaviruses with Lisa Gralinski from 2020-10-22T06:00
Lisa joins TWiV to discuss her research on the pathogenesis of SARS-CoV, MERS-CoV, and SARS-CoV-2, including work on vaccines and an antiviral, then we review the SARS-CoV-2 spike protein as a pote...
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TWiV 673: Wake up and smell the pandemic from 2020-10-18T06:00
Daniel Griffin provides a clinical report on COVID-19, we debunk the Great Barrington Declaration, and discuss smell and taste changes as early indicators of the pandemic, vascular disease and thro...
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TWiV 672: Black in Microbiology with Ari Kozik and Kishana Taylor from 2020-10-15T06:00
Ari and Kishana, two of the founders of Black in Microbiology, join TWiV to discuss the goals of the organization, then we review pauses of J&J and Lilly COVID-19 vaccine trials, preclinical studie...
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TWiV 671: Prizes, polio, and a pandemic puzzle from 2020-10-11T06:00
Daniel Griffin provides a clinical report on COVID-19, then Amy joins us to discuss the 2020 Chemistry Nobel Prize for gene editing using CRISPR/Cas9, continuing circulation of poliovirus in Afghan...
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TWiV 670: Coronavirus vaccine preparedness with Kizzmekia Corbett from 2020-10-08T06:00
Kizzmekia Corbett joins TWiV to review her career and her work on respiratory syncytial virus, influenza virus, and coronaviruses and coronavirus vaccines, including her role in development and tes...
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TWiV Special: Presidential COVID-19 with Dr. Daniel Griffin from 2020-10-06T01:39:35
Daniel Griffin discusses President Trump's case of COVID-19, including the clinical course, the medications he received and why, and expectations for the next few weeks.
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TWiV 669: All the wrong COVID-19 moves from 2020-10-04T06:00
Daniel Griffin provides a clinical report on COVID-19, including a discussion of the role of vitamin D in COVID-19, Michael and Christopher explain why we have made all the wrong moves during the p...
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TWiV 668: Mice, bats, and coronaviruses with Tony Schountz from 2020-10-01T06:00
Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to unders...
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TWiV 667: Building a better virus trap from 2020-09-27T06:00
Daniel Griffin provides a clinical report on COVID-19, review of the phase I and II trials of the Russian prime-boost vaccine, a mouse model that recapitulates age-dependent severe disease, and lis...
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TWiV 666: A far-UVC light bulb went off for David Brenner from 2020-09-24T06:00
David Brenner joins TWiV to explain how far-UVC lights could provide protection from SARS-CoV-2 and other airborne viruses in public places, solutions to face mask fogging, transmission during airp...
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TWiV 665: This half-week in coronavirology from 2020-09-20T06:00
Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by ...
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TWiV 664: TWiV is for the dogs from 2020-09-17T06:00
On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nat...
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TWiV 663: The joy of vax from 2020-09-13T06:30
Daniel Griffin provides a clinical report on COVID-19, including vaccines, Alan summarizes a vaccine webinar on the most advanced US trials, a nidovirus from snapping turtles, longevity of memory B...
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TWiV 662: Principals of Principles, Fifth Edition from 2020-09-11T07:00
The authors of the textbook Principles of Virology gather to reveal new additions to the fifth edition, including a new author, study questions, and a chapter on therapeutic viruses.
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TWiV 661: SWAG with Ralph Baric from 2020-09-10T07:00
Ralph Baric returns to TWiV to provide an update on the COVID-19 resurgence in the US, monoclonal antibodies, antiviral drugs, vaccines, immunity and reinfection, reopening schools, and what will h...
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TWiV 660: In case of emergency finish the trial from 2020-09-06T07:00
Daniel Griffin provides a clinical report on COVID-19, then we discuss decline of virus-specific bone marrow B cells within a year after influenza vaccination, the push to release SARS-CoV-2 vaccin...
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TWiV 659: Sloppy coronavirus immunity with Christian Drosten from 2020-09-03T07:00
Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and ...
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TWiV 658: Everyone needs a H.E.A.R.T. from 2020-08-30T07:00
Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfec...
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TWiV 657: Shane Crotty on SARS-CoV-2 immunity from 2020-08-27T07:00
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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TWiV 656: See, it can be done! from 2020-08-23T07:00
Daniel Griffin provides a clinical report on COVID-19, surgeons Lisa Smith and David Bruce detail how they have helped their Chattanooga community during the pandemic, then we discuss racial and et...
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TWiV 655: Minority health with Robert Fullilove from 2020-08-20T07:00
Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice afte...
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TWiV 654: TWiVering with excitement from 2020-08-16T07:00
Daniel Griffin provides a clinical report on COVID-19 and the convalescent plasma trial, then we answer listener questions about the Russian vaccine, choir practice, face masks (wear them!), Mina t...
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TWiV 653: Back to school with COVID-19 from 2020-08-14T07:00
Alfonso, Ken, Mary and Janet join TWiV to explain their modeling of school reopening strategies during the SARS-CoV-2 pandemic.
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TWiV 652: The rules of contagion with Adam Kucharski from 2020-08-13T07:00
Epidemiologist Adam Kucharski joins TWiV to discuss SARS-CoV-2, including R0, incubation period, herd immunity, asymptomatic infection, superspreaders, children as drivers of pandemics, and how thi...
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TWiV 651: FDA rules with Denise Esposito from 2020-08-09T07:00
Daniel Griffin provides a clinical report on COVID-19, then former FDA Chief of Staff to the Commissioner Denise Esposito joins us to explain the challenges in approving vaccines, antiviral drugs, ...
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TWiV 650: Virology is infinite from 2020-08-06T07:00
In this mid-week episode of Earth's Virology Podcast, we analyze SARS-CoV-2 transmission among youths at a summer camp, adaptation to mice by passage, the importance of T cells for recovery from CO...
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TWiV 649: Ohio State viral from 2020-08-04T07:00
Vincent visits Ohio State University (March 2020) and speaks with Shan-Lu, David, Amanda, Mark, Matt, Chris, and Qiuhong about their careers and their work on retroviruses, hepatitis C virus, coron...
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TWiV 648: Life is for learning from 2020-08-02T07:00
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the findings that children shed as much SARS-CoV-2 viral RNA from the respiratory tract as older patients, the lineage...
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TWiV 647: Testing is our way out of this crisis from 2020-07-30T07:00
In this mid-week TWiV, children under 10 do transmit SARS-CoV-2, why hydroxychloroquine does not work for treating COVID-19, scale-up of diagnostic testing, explanation of LAMP testing, and listene...
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TWiV 646: Virocentricity II with Eugene Koonin from 2020-07-28T07:00
From the NIH campus (recorded February 2020) Vincent and Rich meet with Eugene Koonin to discuss his theories on the evolutionary origins of viruses.
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TWiV 645: Lions and tigers and zookeepers (oh my) from 2020-07-26T07:00
Daniel Griffin provides a clinical report on COVID-19, followed by a review of the State Department document on the Wuhan BSL-4 laboratory, the report on infection of tigers and lions in the Bronx ...
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TWiV 644: Don't let perfect be the enemy of good from 2020-07-23T07:00
In this mid-week edition, identifying flawed research before it becomes dangerous, Michigan governor tells America to mask-up, Pfizer mRNA vaccine gets $1.95 billion from Warp Speed, preliminary ph...
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TWiV 643: Bernie Moss, the real Poxdoc from 2020-07-21T07:00
From the NIH campus (recorded February 2019) Vincent and Rich meet with Bernie Moss to hear about his training and his remarkable 50-year-plus career working on poxviruses.
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TWiV 642: Bringin' in 50 keys of spike mRNA from 2020-07-19T07:00
Daniel Griffin provides a clinical update on COVID-19, then we discuss phase I preliminary results of the SARS-CoV-2 mRNA vaccine, factors associated with death in 17 million patients, and answer l...
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TWiV 641: COVID-19 with Dr. Anthony Fauci from 2020-07-17T07:00
Dr. Anthony Fauci joins TWiV to discuss SARS-CoV-2 transmission, testing, immunity, pathogenesis, vaccines, and preparedness.
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TWiV 640: Test often, fast turnaround, with Michael Mina from 2020-07-16T07:00
Michael Mina joins TWiV to reveal why frequent and rapid SARS-CoV-2 testing is more important than accuracy, how a daily $1 rapid test could control the pandemic, and why group testing works.
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TWiV 639: Virology Nobel Prizes with Erling Norrby part 2 from 2020-07-14T07:00
Vincent and Erling resume their discussion of virology Nobel Prizes, focusing on awards for research on tumor viruses, bacteriophages, virus structure, reverse transcriptase, hepatitis B virus, HIV...
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TWiV 638: Do, there is no try from 2020-07-12T07:00
Daniel Griffin provides a clinical update on COVID-19, then Viviana Simon joins to review serological assays developed at Mt. Sinai for SARS-CoV-2 infection, tracking the outbreak in NYC, and liste...
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TWiV 637: Clearing the fog of ignorance from 2020-07-09T07:00
In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-...
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TWiV 636: Georgia State viral from 2020-07-07T07:00
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development.
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TWiV 635: Mask hysteria from 2020-07-05T07:00
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much ...
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TWiV 634: 1000 hours of the sunlight of TWiV from 2020-07-02T07:00
TWiV reviews a new H1N1 swine influenza virus from China with pandemic potential, Ad5 vectored SARS-CoV-2 oral vaccine candidate, Operation Warp Speed vaccine candidates, FDA guidance on vaccine ap...
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TWiV 633: Singapore viral from 2020-06-30T07:00
From DukeNUS Medical School, Vincent speaks with Ashley, Sheemei, Eng Eong and Dahai about their careers and their research on flaviviruses and sensing of viral RNA.
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TWiV 632: Countering a miasma of anti-think from 2020-06-28T07:00
Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 infections in non-humans, vesicular stomatitis in Kansas horses, and answer listener questions.
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TWiV 631: Lots of eggs in the spike basket from 2020-06-25T07:00
Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial ...
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TWiV 630: Singapore Environmental Health Institute from 2020-06-24T07:00
From the Environmental Health Institute in Singapore, Vincent speaks with Director Lee Ching Ng about their work to control viral infectious diseases, including the controlled release of mosquitoes...
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TWiV 629: Coronavirus update, pandemic sitrep from 2020-06-21T07:00
Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymp...
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TWiV 628: Physical distance for COVID-19 from 2020-06-18T07:00
Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the labor...
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